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Multi-omics insights of immune cells in the risk and prognosis of idiopathic membranous nephropathy.
Communications biology
Aug 10, 2025
Idiopathic membranous nephropathy (IMN) is the major cause of autoimmune-related nephrotic syndrome. The role immune cells play in the risk and prognosis of IMN remains elusive. We employ multi-omics data and a variety of approaches to evaluate the c...
Human-alignment influences the utility of AI-assisted decision making.
Scientific reports
Aug 9, 2025
Whenever an AI model is used to predict a relevant (binary) outcome in AI-assisted decision making, it is widely agreed that, together with each prediction, the model should provide an AI confidence value. However, it has been unclear why decision ma...
Non-coding genetic elements of lung cancer identified using whole genome sequencing in 13,722 Chinese.
Nature communications
Aug 9, 2025
A substantial portion of lung cancer-associated genetic elements in East Asian populations remains unidentified, underscoring the need for large-scale genome-wide studies, particularly on non-coding regulation. We conducted a whole genome sequencing ...
Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation.
Nature communications
Aug 9, 2025
Auranofin, an FDA-approved antirheumatic gold drug, has gained ongoing interest in clinical studies for treating advanced or recurrent tumors. However, gold ion's dynamic thiol exchange nature strongly attenuates its bioactivity due to the fast forma...
Serum peptide biomarkers by MALDI-TOF MS coupled with machine learning for diagnosis and classification of hepato-pancreato-biliary cancers.
Scientific reports
Aug 9, 2025
This study aimed to investigate the potential of peptide mass fingerprints (PMFs) of the serum peptidome using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), in combination with machine learning algorithm...
Unveiling social determinants of health impact on adverse pregnancy outcomes through natural language processing.
Scientific reports
Aug 9, 2025
Understanding the role of Social Determinants of Health (SDoH) in pregnancy outcomes is critical for improving maternal and infant health yet extracting SDoH from unstructured electronic health records remains challenging. We trained and evaluated na...
Exploring the feasibility of AI-based analysis of histopathological variability in salivary gland tumours.
Scientific reports
Aug 9, 2025
This study uses artificial intelligence (AI) for differentiation between salivary gland tumours (SGT) using digitised Haematoxylin and Eosin stained whole-slide images (WSI). Machine learning (ML) classifiers were developed and tested using 320 scann...
Application of causal forest double machine learning (DML) approach to assess tuberculosis preventive therapy's impact on ART adherence.
Scientific reports
Aug 9, 2025
Adherence to antiretroviral therapy (ART) is critical for HIV treatment success, yet the impact of tuberculosis preventive therapy (TPT) remains inadequately understood. Using observational data from 4152 HIV patients in Ethiopia (2005-2024), we appl...
WGCNA combined with machine learning for analysis of diagnostic markers of preeclampsia associated with the hedgehog signaling pathway.
Hypertension in pregnancy
Aug 8, 2025
BACKGROUND: Abnormal hedgehog (Hh) signaling is linked to preeclampsia (PE). This study aimed to identify Hh-related diagnostic biomarkers for PE and assess the role of immune infiltration.
Development and validation of interpretable machine learning models for predicting AKI risk in patients treated with PD-1/PD-L1: a retrospective study.
BMC medical informatics and decision making
Aug 8, 2025
BACKGROUND: Anti-programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) immunotherapy has revolutionized cancer treatment. However, it can cause immune-related adverse events, including acute kidney injury (AKI). Such adverse e...
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