AIMC Topic: Fibroblasts
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Optimizing parameters on alignment of PCL/PGA nanofibrous scaffold: An artificial neural networks approach.
International journal of biological macromolecules
Oct 27, 2014
This paper proposes an artificial neural networks approach to finding the effects of electrospinning parameters on alignment of poly(ɛ-caprolactone)/poly(glycolic acid) blend nanofibers. Four electrospinning parameters, namely total polymer concentra...
A high-throughput analysis of novel anti-fibrotics in human adult cardiac fibroblasts.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Jul 1, 2025
Myocardial fibrosis, a hallmark of heart failure (HF), contributes to disease progression and mortality by impairing cardiac function. Despite the identification of potential anti-fibrotic molecules, there is a lack of effective pharmacological inter...
Annexin A2 Contributes to Release of Extracellular Vimentin in Response to Inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
May 15, 2025
Vimentin, an abundant intracellular cytoskeletal protein, is secreted into the extracellular space, where it can amplify tissue destruction in inflammatory diseases. The mechanisms by which inflammation promotes the release of extracellular vimentin ...
Transcriptome-wide analysis reveals potential roles of CFD and ANGPTL4 in fibroblasts regulating B cell lineage for extracellular matrix-driven clustering and novel avenues for immunotherapy in breast cancer.
Molecular medicine (Cambridge, Mass.)
May 8, 2025
BACKGROUND: The remodeling of the extracellular matrix (ECM) plays a pivotal role in tumor progression and drug resistance. However, the compositional patterns of ECM in breast cancer and their underlying biological functions remain elusive.
3D Bioprinting Skin Equivalents: A Methodological Perspective on Human Keratinocyte and Fibroblast Models for Wound Repair and Regeneration.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Jan 1, 2025
Three-dimensional (3D) bioprinting is a promising approach to developing reliable tissue substitutes for translational research. The great interest in creating skin substitutes still faces challenges considering its structural and cellular complexity...
[Evaluation of the efficacy of antifibrotic drugs on cell cultures in Salzmann's nodular degeneration].
Vestnik oftalmologii
Jan 1, 2024
UNLABELLED: Excessive production of extracellular matrix is a key component in the pathogenesis of Salzmann's nodular degeneration (SND). studies of drugs that suppress excessive fibroblast activity may become crucial in developing pathogenetically ...
Classifying Microscopic Acute and Old Myocardial Infarction Using Convolutional Neural Networks.
The American journal of forensic medicine and pathology
Sep 1, 2021
Convolutional neural network (CNN) has advanced in recent years and translated from research into medical practice, most notably in clinical radiology and histopathology. Research on CNNs in forensic/postmortem pathology is almost exclusive to postmo...
Quantitative scoring of epithelial and mesenchymal qualities of cancer cells using machine learning and quantitative phase imaging.
Journal of biomedical optics
Feb 1, 2020
SIGNIFICANCE: We introduce an application of machine learning trained on optical phase features of epithelial and mesenchymal cells to grade cancer cells' morphologies, relevant to evaluation of cancer phenotype in screening assays and clinical biops...
[Interleukin?22 promotes proliferation of fibroblast?like synoviocytes from patients with rheumatoid arthritis by inducing STAT3 phosphorylation].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Dec 20, 2017
OBJECTIVE: To clarify the mechanism by which interleukin?22 (IL?22) promotes the proliferation of fibroblast?like synoviocytes (FLS) from patients with rheumatoid arthritis (RA).
CONDITIONS OF PROOXIDANT ACTIVITY OF CISTUS AND POMEGRANATE POLYPHENOLS IN V79 CELL CULTURES.
Acta poloniae pharmaceutica
Mar 1, 2017
Polyphenol rich extracts obtained from cistus herb (Cistus incanus L.) and pomegranate peels (Punica granatunm L.) added at high concentrations (25-100 pg/mL) to V79 (Chinese hamster lung fibroblast) cell cultures, markedly increased intracellular le...
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