BACKGROUND: Accurate diagnosis of Parkinson's Disease (PD) remains challenging due to its biological complexity. Integrating machine learning with multi-omics and network topological analyses may enhance diagnostic precision.
BACKGROUND: In the context of liver resection and transplantation, hepatic ischemia-reperfusion injury (hepatic IRI) remains a significant clinical challenge, profoundly impacting both postoperative short- and long-term recovery. A novel cell death p...
Pulmonary hypertension (PH) is a progressive cardiopulmonary disorder. It features elevated pulmonary arterial pressure, which leads to right ventricular failure and increased mortality. PH's insidious nature, with no specific clinical symptoms, hind...
Accumulating evidence has demonstrated that biological processes associated with liquid-liquid phase separation (LLPS) play a critical role in cancer development. However, the effect of LLPS on hepatocellular carcinoma (HCC) remains largely unknown. ...
Acute myocardial infarction (AMI) stands as a major contributor to mortality and disability worldwide, with obesity playing a significant role in its development. This study aims to investigate potential biomarkers associated with obesity-related gen...
BACKGROUND: Periodontitis (PD) is a chronic, multifactorial inflammatory disorder characterized by the progressive destruction of periodontal tissues. Increasing evidence indicates that the dysregulation of hypoxia-related genes (HRGs) plays a pivota...
Proceedings of the National Academy of Sciences of the United States of America
Dec 26, 2025
Retinal ganglion cells (RGCs) transmit visual information from the eye to the brain. In mice, several RGC types show nonuniform spatial distributions, potentially mediating specific visual functions. However, the full extent of RGC specialization rem...
BACKGROUND: Ischemic stroke (IS) is a cerebrovascular disease resulting from insufficient blood supply to specific areas of the brain, often due to atherosclerosis and thrombosis. While the association between polymorphisms in coagulation-related gen...
BACKGROUND: The development of spatial transcriptomics (ST) has enabled biologists to measure transcriptome data on an entire tissue and retain spatial information. It gives us the opportunity to fully understand the tissue microenvironment and ident...
Orthostatic hypotension is a sharp decrease in blood pressure when an individual transitions from a supine to an upright position. OH affects at least 30% of older adults. It is attributed to the dysfunction of the autonomic innervation and decreased...
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