AIMC Topic: Gene Expression Profiling
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Comprehensive machine learning analysis of PANoptosis signatures in multiple myeloma identifies prognostic and immunotherapy biomarkers.
Scientific reports
Jul 2, 2025
PANoptosis is closely associated with tumorigenesis and therapeutic response, yet its role in multiple myeloma (MM) remains unclear. This study analyzed bulk transcriptomic and clinical data from the TCGA and GEO databases to identify seven PANoptosi...
Iron metabolism and preeclampsia: new insights from bioinformatics analysis.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Jul 1, 2025
OBJECTIVE: Preeclampsia (PE) is a multifactorial systemic pregnancy disease, in which iron metabolism and ferroptosis play significant roles during its pathogenesis. The diagnosis and prevention of PE remain urgent clinical issues that need to be add...
Identification of potential pathogenic genes associated with the comorbidity of rheumatoid arthritis and renal fibrosis using bioinformatics and machine learning.
Scientific reports
Jul 1, 2025
This study aimed to identify the potential pathogenic genes associated with the comorbidity of rheumatoid arthritis (RA) and renal fibrosis (RF). Transcriptomic data related to RA and RF were retrieved from the GEO database. Differential expression g...
Decoding the diagnostic biomarkers of mitochondrial dysfunction related gene variants in pediatric T cell acute lymphoblastic leukemia.
Scientific reports
Jul 1, 2025
Mitochondrial dysfunction is crucial in the pathogenesis and drug resistance of pediatric T-cell acute lymphoblastic leukemia (T-ALL), a malignant hematological disorder with unrestrained proliferation of immature T-cells. Therefore, the primary obje...
Identification of CXCR4 as a potential preventive gene in clear cell renal cell carcinoma from machine learning and immune analysis.
Scientific reports
Jul 1, 2025
Clear cell renal cell carcinoma (ccRCC) represents a prevalent malignant kidney tumor characterized by high metastatic potential and recurrence rates. Investigations into the molecular mechanisms and therapeutic targets of ccRCC have provided novel d...
Potential role of TNFRSF12A in linking glioblastoma and alzheimer's disease via shared tumour suppressor pathways.
Scientific reports
Jul 1, 2025
Tumor suppressor genes (TSGs) are critical regulators of cellular homeostasis and are extensively studied in cancer biology. However, their roles in neurodegenerative diseases, particularly Alzheimer's disease (AD), remain poorly understood. Recent e...
Shared gene signatures and molecular mechanisms link ankylosing spondylitis and rheumatoid arthritis.
Scientific reports
Jul 1, 2025
Ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are closely related autoimmune diseases with shared mechanisms that remain unclear. This study aims to identify shared molecular signatures and hub genes underlying the co-occurrence of AS and...
Integrated analysis of shared gene expression signatures and immune microenvironment heterogeneity in type 2 diabetes mellitus and colorectal cancer.
Scientific reports
Jul 1, 2025
Emerging evidence suggests a bidirectional relationship between colorectal cancer (CRC) and type 2 diabetes mellitus (T2DM), yet the shared molecular mechanisms and prognostic biomarkers remain poorly characterized. This study aimed to identify novel...
Identification of key genes associated with cellular aging and mitochondria in acute myocardial infarction.
Scientific reports
Jul 1, 2025
Acute myocardial infarction (AMI) poses a significant global mortality burden. Utilizing bio informatics, this study explored cellular aging-related genes (CARGs) and mitochondrial-related genes (MRGs). in AMI Public AMI datasets were analyzed using ...
Identification and verification of immune and oxidative stress-related diagnostic indicators for malignant lung nodules through WGCNA and machine learning.
Scientific reports
Jul 1, 2025
Early detection of lung nodules (LNs) is critical for prevention and treatment of lung cancer. However, current noninvasive diagnostic methods face significant challenges in reliably distinguishing benign from malignant nodules. Thus, there is an urg...
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