AIMC Topic: Gene Expression Profiling

Clear Filters Showing 251 to 260 of 1305 articles

Impact of glioma metabolism-related gene ALPK1 on tumor immune heterogeneity and the regulation of the TGF-β pathway.

Frontiers in immunology Jan 7, 2025
BACKGROUND: Recent years have seen persistently poor prognoses for glioma patients. Therefore, exploring the molecular subtyping of gliomas, identifying novel prognostic biomarkers, and understanding the characteristics of their immune microenvironme...
Gene Regulatory Networks Gene Expression Regulation, Neoplastic Signal Transduction Glioma Tumor Microenvironment Biomarkers, Tumor Brain Neoplasms Gene Expression Profiling Humans Machine Learning Prognosis
View on PubMed DOI

Integrating single cell analysis and machine learning methods reveals stem cell-related gene S100A10 as an important target for prediction of liver cancer diagnosis and immunotherapy.

Frontiers in immunology Jan 7, 2025
BACKGROUND: Hepatocellular carcinoma (LIHC) poses a significant health challenge worldwide, primarily due to late-stage diagnosis and the limited effectiveness of current therapies. Cancer stem cells are known to play a role in tumor development, met...
Carcinoma, Hepatocellular Humans Single-Cell Analysis Neoplastic Stem Cells Machine Learning Biomarkers, Tumor Immunotherapy S100 Proteins Prognosis Gene Expression Profiling Gene Expression Regulation, Neoplastic Liver Neoplasms
View on PubMed DOI

Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma.

Frontiers in immunology Jan 6, 2025
BACKGROUND: The Aryl Hydrocarbon Receptor (AhR) pathway significantly influences immune cell regulation, impacting the effectiveness of immunotherapy and patient outcomes in melanoma. However, the specific downstream targets and mechanisms by which A...
Lymphocytes, Tumor-Infiltrating Receptors, Aryl Hydrocarbon Databases, Genetic Basic Helix-Loop-Helix Transcription Factors Transcriptome Mice Prognosis Computational Biology Melanoma Gene Expression Regulation, Neoplastic Skin Neoplasms Biomarkers, Tumor Tumor Microenvironment Humans Animals Gene Expression Profiling Machine Learning
View on PubMed DOI

DeepQA: A Unified Transcriptome-Based Aging Clock Using Deep Neural Networks.

Aging cell Jan 5, 2025
Understanding the complex biological process of aging is of great value, especially as it can help develop therapeutics to prolong healthy life. Predicting biological age from gene expression data has shown to be an effective means to quantify aging ...
Machine Learning Aging Gene Expression Profiling Humans Transcriptome Neural Networks, Computer
View on PubMed DOI

Development of machine learning models for diagnostic biomarker identification and immune cell infiltration analysis in PCOS.

Journal of ovarian research Jan 3, 2025
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. It is characterized by symptoms such as hyperandrogenemia, oligo or anovulation and polycystic ovarian, significantly impacting quality o...
Female Gene Expression Profiling ROC Curve Polycystic Ovary Syndrome Humans Machine Learning Biomarkers
View on PubMed DOI

Machine learning based identification of an amino acid metabolism related signature for predicting prognosis and immune microenvironment in pancreatic cancer.

BMC cancer Jan 3, 2025
BACKGROUND: Pancreatic cancer is a highly aggressive neoplasm characterized by poor diagnosis. Amino acids play a prominent role in the occurrence and progression of pancreatic cancer as essential building blocks for protein synthesis and key regulat...
Pancreatic Neoplasms Amino Acids Gene Expression Profiling Transcriptome Gene Expression Regulation, Neoplastic Humans Machine Learning Prognosis Female Tumor Microenvironment Biomarkers, Tumor Male
View on PubMed DOI

Common biomarkers of idiopathic pulmonary fibrosis and systemic sclerosis based on WGCNA and machine learning.

Scientific reports Jan 3, 2025
Interstitial lung disease (ILD) is known to be a major complication of systemic sclerosis (SSc) and a leading cause of death in SSc patients. As the most common type of ILD, the pathogenesis of idiopathic pulmonary fibrosis (IPF) has not been fully e...
Humans Machine Learning Gene Expression Profiling Gene Regulatory Networks Idiopathic Pulmonary Fibrosis Chemokine CCL2 Biomarkers Female Male Middle Aged Scleroderma, Systemic
View on PubMed DOI

Transcriptomic profiling and machine learning reveal novel RNA signatures for enhanced molecular characterization of Hashimoto's thyroiditis.

Scientific reports Jan 3, 2025
While ultrasonography effectively diagnoses Hashimoto's thyroiditis (HT), exploring its transcriptomic landscape could reveal valuable insights into disease mechanisms. This study aimed to identify HT-associated RNA signatures and investigate their p...
RNA, Circular Gene Expression Profiling Transcriptome Case-Control Studies Gene Regulatory Networks RNA, Messenger MicroRNAs RNA, Long Noncoding Female Hashimoto Disease Adult Humans Male Machine Learning Middle Aged
View on PubMed DOI

Utilizing integrated bioinformatics and machine learning approaches to elucidate biomarkers linking sepsis to purine metabolism-associated genes.

Scientific reports Jan 2, 2025
Sepsis, characterized as a systemic inflammatory response triggered by pathogen invasion, represents a continuum that may progress from mild systemic infection to severe sepsis, potentially culminating in septic shock and multiple organ dysfunction s...
Biomarkers Gene Expression Profiling Sepsis Computational Biology Humans Machine Learning Support Vector Machine Purines
View on PubMed DOI

Identification of key gene signatures for predicting chemo-immunotherapy efficacy in extensive-stage small-cell lung cancer using machine learning.

Lung cancer (Amsterdam, Netherlands) Jan 2, 2025
OBJECTIVES: The lack of definitive biomarkers presents a significant challenge for chemo-immunotherapy in extensive-stage small-cell lung cancer (ES-SCLC). We aimed to identify key genes associated with chemo-immunotherapy efficacy in ES-SCLC through...
Humans Machine Learning Prospective Studies Transcriptome Antineoplastic Combined Chemotherapy Protocols Biomarkers, Tumor Prognosis Lung Neoplasms Male Female Treatment Outcome Immunotherapy Middle Aged Neoplasm Staging Aged Gene Expression Regulation, Neoplastic Gene Expression Profiling Small Cell Lung Carcinoma
View on PubMed DOI
Popular Topics
Recent Journals