AIMC Topic: Gene Expression Profiling

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Integrated multi-omics analysis of ovarian cancer using variational autoencoders.

Scientific reports Mar 18, 2021
Cancer is a complex disease that deregulates cellular functions at various molecular levels (e.g., DNA, RNA, and proteins). Integrated multi-omics analysis of data from these levels is necessary to understand the aberrant cellular functions accountab...
Epigenomics Cluster Analysis Ovarian Neoplasms Kaplan-Meier Estimate Prognosis Female Gene Expression Profiling Transcriptome Humans Genomics Computational Biology Data Analysis Epigenesis, Genetic Deep Learning Cohort Studies
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Machine learning analysis of gene expression profile reveals a novel diagnostic signature for osteoporosis.

Journal of orthopaedic surgery and research Mar 15, 2021
BACKGROUND: Osteoporosis (OP) is increasingly prevalent with the aging of the world population. It is urgent to identify efficient diagnostic signatures for the clinical application.
Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Signaling Lymphocytic Activation Molecule Family Male Gene Expression Profiling Transcriptome Protein Interaction Maps RNA, Messenger Logistic Models Potassium Channels Humans CD5 Antigens Machine Learning Osteoporosis Female
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Virtual Transcriptomics: Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging.

Arteriosclerosis, thrombosis, and vascular biology Mar 11, 2021
[Figure: see text].
Phenotype Female Aged Male Humans Artificial Intelligence Predictive Value of Tests Coronary Angiography Radiographic Image Interpretation, Computer-Assisted Coronary Artery Disease Feasibility Studies Gene Expression Profiling Transcriptome Pilot Projects Models, Genetic Coronary Vessels Plaque, Atherosclerotic Oligonucleotide Array Sequence Analysis Computed Tomography Angiography
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Expanding the drug discovery space with predicted metabolite-target interactions.

Communications biology Mar 5, 2021
Metabolites produced in the human gut are known modulators of host immunity. However, large-scale identification of metabolite-host receptor interactions remains a daunting challenge. Here, we employed computational approaches to identify 983 potenti...
Ligands Molecular Targeted Therapy Host-Pathogen Interactions Inflammatory Bowel Diseases Metabolome Drug Discovery Anti-Inflammatory Agents Humans Gene Expression Profiling Gastrointestinal Agents Signal Transduction Machine Learning Transcriptome Protein Interaction Maps Data Mining Bacteria Gastrointestinal Microbiome Cells, Cultured Metabolomics Databases, Factual
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Novel gene signatures for stage classification of the squamous cell carcinoma of the lung.

Scientific reports Mar 1, 2021
The squamous cell carcinoma of the lung (SCLC) is one of the most common types of lung cancer. As GLOBOCAN reported in 2018, lung cancer was the first cause of death and new cases by cancer worldwide. Typically, diagnosis is made in the later stages ...
Humans Gene Expression Profiling Machine Learning Gene Expression Regulation, Neoplastic Lung Neoplasms Carcinoma, Non-Small-Cell Lung Female Databases, Nucleic Acid Biomarkers, Tumor Male
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Machine Learning Identifies Complicated Sepsis Course and Subsequent Mortality Based on 20 Genes in Peripheral Blood Immune Cells at 24 H Post-ICU Admission.

Frontiers in immunology Feb 22, 2021
A complicated clinical course for critically ill patients admitted to the intensive care unit (ICU) usually includes multiorgan dysfunction and subsequent death. Owing to the heterogeneity, complexity, and unpredictability of the disease progression,...
Chromosome Mapping Time Factors Databases, Genetic Reproducibility of Results Humans Hospital Mortality Leukocytes Gene Expression Profiling Machine Learning ROC Curve Critical Care Transcriptome Biomarkers Computational Biology Disease Susceptibility Sepsis Intensive Care Units
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Machine learning identifies candidates for drug repurposing in Alzheimer's disease.

Nature communications Feb 15, 2021
Clinical trials of novel therapeutics for Alzheimer's Disease (AD) have consumed a large amount of time and resources with largely negative results. Repurposing drugs already approved by the Food and Drug Administration (FDA) for another indication i...
Drugs, Investigational Gene Expression Profiling Pharmacogenetics Polypharmacology Neuroprotective Agents Nerve Tissue Proteins Humans Gene Expression Regulation Drug Repositioning Machine Learning Primary Cell Culture Cerebral Cortex Severity of Illness Index Neurons Prescription Drugs Alzheimer Disease Nootropic Agents High-Throughput Screening Assays
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Machine learning for the analysis of multi-omics data.

Methods (San Diego, Calif.) Feb 9, 2021
Genomics Epigenomics Proteomics Metagenomics Machine Learning Gene Expression Profiling
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A novel gene selection method for gene expression data for the task of cancer type classification.

Biology direct Feb 8, 2021
Cancer is a poligenetic disease with each cancer type having a different mutation profile. Genomic data can be utilized to detect these profiles and to diagnose and differentiate cancer types. Variant calling provide mutation information. Gene expres...
Gene Expression Profiling Machine Learning Genomics Algorithms Neoplasms
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Integrated analysis of multiple microarray studies to identify novel gene signatures in preeclampsia.

Placenta Feb 2, 2021
INTRODUCTION: Preeclampsia (PE) is one of the major causes of maternal and fetal morbidity and mortality in pregnancy worldwide. However, the intrinsic molecular mechanisms underlying the pathogenesis of PE have not yet been fully elucidated.
Humans Pregnancy Female Gene Expression Profiling Gene Regulatory Networks Gene Ontology Computational Biology Pre-Eclampsia Microarray Analysis
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