We develop GeneRAIN, a suite of Transformer-based models that learn gene expression relationships from 410 K human bulk RNA-seq samples. Featuring a novel Binning-By-Gene normalization technique, our models capture diverse biological information beyo...
Keloid scarring and Metabolic Syndrome (MS) are distinct conditions marked by chronic inflammation and tissue dysregulation, suggesting shared pathogenic mechanisms. Identifying common regulatory genes could unveil novel therapeutic targets. Methods...
BACKGROUND: Ankylosing spondylitis (AS), a chronic inflammatory disorder affecting axial joints, is frequently complicated by uveitis. However, the molecular mechanisms linking AS to secondary uveitis remain poorly understood.
BACKGROUND: Disulfidptosis, a novel cellular death manner, has yet to be fully explored within the context of pulmonary arterial hypertension (PAH). This study aims to identify genes implicated in PAH that are involved in disulfidptosis.
The complexity of the genetic circuit design limits accessibility and efficiency in synthetic biology. This study presents an integrated system that combines Cello software with large language models (DeepSeek-R1, Phi-4) and the LangChain framework i...
Heart failure (HF) represents a significant public health concern, characterized by elevated rates of mortality and morbidity. Recent advancements in gene sequencing technologies have led to the identification of numerous genes associated with heart ...
BACKGROUND: Acute kidney injury (AKI) is a prevalent and life-threatening condition characterized by abrupt renal function decline and subsequent inflammatory cascades. PANoptosis has emerged as a significant contributor to the pathophysiology of AKI...
Preeclampsia (PE), a devastating pregnancy complication affecting 5% of gravidas worldwide, exhibits poorly characterized connections between mitochondrial dysfunction and immune dysregulation. This study aims to identify integrated mitochondrial-imm...
Background Mitochondrial-related genes (MRGs) and programmed cell death-related genes (PCD-RGs) have been proven to play important roles in obsessive-compulsive disorder (OCD), and identifying their shared biomarkers is conducive to the diagnosis and...
Polycystic ovary syndrome (PCOS), a common endocrine condition affecting multiple systems, is tied to atherosclerosis (AS) progression among reproductive-aged women. The present study aimed to explore the underlying associations and uncover potential...
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