BACKGROUND: Viral infections are prevalent in human cancers and they have great diagnostic and theranostic values in clinical practice. Recently, their potential of shaping the tumor immune microenvironment (TIME) has been related to the immunotherap...
OBJECTIVES: We aimed to build a survival system by combining a highly-accurate machine learning (ML) model with explainable artificial intelligence (AI) techniques to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma (NPC...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Mar 8, 2021
Approximately 15% of human cancers are estimated to be attributed to viruses. Virus sequences can be integrated into the host genome, leading to genomic instability and carcinogenesis. Here, a new deep convolutional neural network (CNN) model is deve...
BACKGROUND: According to the 7th edition of the American Joint Committee on Cancer (AJCC) staging system, over 50% of patients with nasopharyngeal carcinoma (NPC) have N1 disease at initial diagnosis. However, patients with N1 NPC are relatively unde...
Epstein-Barr Virus (EBV) is the first tumor virus discovered in humans, which is closely related to the occurrence of a variety of malignant tumors, especially Nasopharyngeal Carcinoma (NPC). Epstein-Barr Virus (EBV)-associated NPC accounts for appro...
The clinical manifestations of infectious mononucleosis (IM) and acute respiratory tract infections (ARTI) exhibit significant similarities. We aim to develop cost-efficient models for IM in children utilizing the Shapley Additive explanation (SHAP) ...
Clinical cancer research : an official journal of the American Association for Cancer Research
May 15, 2025
PURPOSE: The Cancer Genome Atlas (TCGA) project defined four distinct molecular subtypes of esophagogastric adenocarcinoma: microsatellite instable (MSI), Epstein-Barr virus (EBV)-associated, genomically stable (GS), and chromosomally instable (CIN)....
International journal of molecular sciences
May 14, 2025
The management of nasopharyngeal cancer (NPC) is rapidly evolving, with immune checkpoint inhibitors emerging as a prominent treatment approach. However, drug development targeting specific molecular and cellular abnormalities in NPC has slowed. Rece...
BACKGROUND: Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that is known to cause infectious mononucleosis and is associated with several autoimmune diseases and cancers through immune system dysregulation and chronic inflammatory mechanisms.
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