Journal of applied clinical medical physics
Mar 19, 2025
PURPOSE: Balancing quality and efficiency has been a challenge for online adaptive therapy. Most systems start the online re-optimization with the original planning goals. While some systems allow planners to modify the planning goals, achieving a hi...
The American Journal of dermatopathology
Mar 19, 2025
BACKGROUND: Lymph node (LN) assessment is a critical component in the staging and management of cutaneous melanoma. Traditional histopathological evaluation, supported by immunohistochemical staining, is the gold standard for detecting LN metastases....
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Mar 19, 2025
With substantial advances in materials science and electronics, flexible tactile sensors have emerged as a promising sector with extensive applications, notably in human-machine interactions. However, achieving large-area sensing with few sensing uni...
PURPOSE OF REVIEW: The integration of artificial intelligence (AI) into healthcare has significantly impacted the way healthcare is delivered, particularly with generative AI-powered chatbots. This review aims to provide an analysis of the applicatio...
Journal of computational biology : a journal of computational molecular cell biology
Mar 19, 2025
Molecular heterogeneity exists in many biological systems, such as major malignancies or diverse cell populations. Clustering of gene expression profiles has been widely used to dissect molecular heterogeneity. One drawback common to most clustering ...
Journal of chemical information and modeling
Mar 19, 2025
Abdominal aortic aneurysm (AAA) is a life-threatening disorder with limited therapeutic options. Neutrophil extracellular traps (NETs) are formed by a process known as "NETosis" that has been implicated in AAA pathogenesis, yet the roles and prognost...
Journal of chemical information and modeling
Mar 19, 2025
Cell-penetrating peptides (CPPs) are usually short oligopeptides with 5-30 amino acid residues. CPPs have been proven as important drug delivery vehicles into cells through different mechanisms, demonstrating their potential as therapeutic candidates...
ACS biomaterials science & engineering
Mar 19, 2025
Effective drug development for bone-related diseases, such as osteoporosis and metastasis, is hindered by the lack of physiologically relevant in vitro models. Traditional platforms, including standard tissue culture plastic, fail to replicate the st...
Macrovascular complications, including stroke, cardiovascular disease (CVD), and peripheral vascular disease (PVD), significantly contribute to morbidity and mortality in individuals with type 2 diabetes mellitus (T2DM). The aim of this study was to ...
BACKGROUND: Heart failure (HF) is a complex syndrome with varied presentations and progression patterns. Traditional classification systems based on left ventricular ejection fraction (LVEF) have limitations in capturing the heterogeneity of HF. We a...
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