AIMC Topic: Humans

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Myocardial infarction evaluation from stopping time decision toward interoperable algorithmic states in reinforcement learning.

BMC medical informatics and decision making
BACKGROUND: The Elliot wave principle commonly characterizes the impulsive and corrective wave trends for both financial market trends and electrocardiograms. The impulsive wave trends of electrocardiograms can annotate several wave components of hea...

CRISPRpred(SEQ): a sequence-based method for sgRNA on target activity prediction using traditional machine learning.

BMC bioinformatics
BACKGROUND: The latest works on CRISPR genome editing tools mainly employs deep learning techniques. However, deep learning models lack explainability and they are harder to reproduce. We were motivated to build an accurate genome editing tool using ...

Effect of congenital adrenal hyperplasia treated by glucocorticoids on plasma metabolome: a machine-learning-based analysis.

Scientific reports
BACKGROUND: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency leads to impaired cortisol biosynthesis. Treatment includes glucocorticoid supplementation. We studied the specific metabolomics signatures in CAH patients using two di...

Machine learning uncovers cell identity regulator by histone code.

Nature communications
Conversion between cell types, e.g., by induced expression of master transcription factors, holds great promise for cellular therapy. Our ability to manipulate cell identity is constrained by incomplete information on cell identity genes (CIGs) and t...

Detecting cardiac pathologies via machine learning on heart-rate variability time series and related markers.

Scientific reports
In this paper we develop statistical algorithms to infer possible cardiac pathologies, based on data collected from 24 h Holter recording over a sample of 2829 labelled patients; labels highlight whether a patient is suffering from cardiac pathologie...

Machine learning paradigm for dynamic contrast-enhanced MRI evaluation of expanding bladder.

Frontiers in bioscience (Landmark edition)
Delineation of the bladder under a dynamic contrast enhanced (DCE)-MRI protocol requires robust segmentation. However, this method is subject to errors due to variations in the content of fluid within the bladder, as well as presence of air and simil...