AIMC Topic: Humans

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Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space.

Frontiers in immunology
Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different...

Monitoring the level of hypnosis using a hierarchical SVM system.

Journal of clinical monitoring and computing
Monitoring level of hypnosis is a major ongoing challenge for anesthetists to reduce anesthetic drug consumption, avoiding intraoperative awareness and prolonged recovery. This paper proposes a novel automated method for accurate assessing of the lev...

Longitudinal Prediction of Infant Diffusion MRI Data via Graph Convolutional Adversarial Networks.

IEEE transactions on medical imaging
Missing data is a common problem in longitudinal studies due to subject dropouts and failed scans. We present a graph-based convolutional neural network to predict missing diffusion MRI data. In particular, we consider the relationships between sampl...

Deep learning and manual assessment show that the absolute mitotic count does not contain prognostic information in triple negative breast cancer.

Cellular oncology (Dordrecht, Netherlands)
PURPOSE: The prognostic value of mitotic count for invasive breast cancer is firmly established. As yet, however, limited studies have been aimed at assessing mitotic counts as a prognostic factor for triple negative breast cancers (TNBC). Here, we a...

Machine learning approaches to studying the role of cognitive reserve in conversion from mild cognitive impairment to dementia.

International journal of geriatric psychiatry
OBJECTIVES: The overall aim of the present study was to explore the role of cognitive reserve (CR) in the conversion from mild cognitive impairment (MCI) to dementia. We used traditional and machine learning (ML) techniques to compare converter and n...

Anticancer Drug Affects Metabolomic Profiles in Multicellular Spheroids: Studies Using Mass Spectrometry Imaging Combined with Machine Learning.

Analytical chemistry
Multicellular spheroids (hereinafter referred to as spheroids) are 3D biological models. The metabolomic profiles inside spheroids provide crucial information reflecting the molecular phenotypes and microenvironment of cells. To study the influence o...

Temporal stability assessment in shear wave elasticity images validated by deep learning neural network for chronic liver disease fibrosis stage assessment.

Medical physics
PURPOSE: To automatically detect and isolate areas of low and high stiffness temporal stability in shear wave elastography (SWE) image sequences and define their impact in chronic liver disease (CLD) diagnosis improvement by means of clinical examina...

A deep learning framework for automatic detection of arbitrarily shaped fiducial markers in intrafraction fluoroscopic images.

Medical physics
PURPOSE: Real-time image-guided adaptive radiation therapy (IGART) requires accurate marker segmentation to resolve three-dimensional (3D) motion based on two-dimensional (2D) fluoroscopic images. Most common marker segmentation methods require prior...

Machine Learning for Diagnosis of Hematologic Diseases in Magnetic Resonance Imaging of Lumbar Spines.

Scientific reports
We aimed to assess feasibility of a support vector machine (SVM) texture classifier to discriminate pathologic infiltration patterns from the normal bone marrows in MRI. This retrospective study included 467 cases, which were split into a training (n...