AIMC Topic: Hydrophobic and Hydrophilic Interactions

Clear Filters Showing 51 to 60 of 74 articles

Protein Solvent-Accessibility Prediction by a Stacked Deep Bidirectional Recurrent Neural Network.

Biomolecules May 25, 2018
Residue solvent accessibility is closely related to the spatial arrangement and packing of residues. Predicting the solvent accessibility of a protein is an important step to understand its structure and function. In this work, we present a deep lear...
Deep Learning Solubility Hydrophobic and Hydrophilic Interactions Protein Conformation Sequence Analysis, Protein Humans Animals
View on PubMed DOI

Robotic Patterning a Superhydrophobic Surface for Collective Cell Migration Screening.

Tissue engineering. Part C, Methods Mar 27, 2018
Collective cell migration, in which cells migrate as a group, is fundamental in many biological and pathological processes. There is increasing interest in studying the collective cell migration in high throughput. Cell scratching, insertion blocker,...
Bone Neoplasms Printing, Three-Dimensional Robotics Human Umbilical Vein Endothelial Cells Nanotechnology Humans Cells, Cultured Cell Movement Cell Survival Osteosarcoma Hydrophobic and Hydrophilic Interactions Silicon Cell Tracking
View on PubMed DOI

Statistical moments in modelling of swelling, erosion and drug release of hydrophilic matrix-tablets.

International journal of pharmaceutics Feb 1, 2018
Statistical moments were evaluated as suitable parameters for describing swelling and erosion processes (along with drug release) in hydrophilic controlled release matrix tablets. The effect of four independent formulation variables, corresponding to...
Kinetics Neural Networks, Computer Drug Compounding Tablets Water Solubility Linear Models Models, Statistical Drug Liberation Technology, Pharmaceutical Drug Carriers Hydrophobic and Hydrophilic Interactions Delayed-Action Preparations Polymers Nimodipine
View on PubMed DOI

A novel method for the production of core-shell microparticles by inverse gelation optimized with artificial intelligent tools.

International journal of pharmaceutics Jan 16, 2018
Numerous studies have been focused on hydrophobic compounds encapsulation as oils. In fact, oils can provide numerous health benefits as synergic ingredient combined with other hydrophobic active ingredients. However, stable microparticles for pharma...
Neural Networks, Computer Artificial Intelligence Fuzzy Logic Capsules Technology, Pharmaceutical Chemistry, Pharmaceutical Alginates Microspheres Equipment Design Emulsions Hydrophobic and Hydrophilic Interactions Drug Compounding Gels Glucuronic Acid Hexuronic Acids Calcium Chloride Sunflower Oil
View on PubMed DOI

Amino acid conjugated antimicrobial drugs: Synthesis, lipophilicity- activity relationship, antibacterial and urease inhibition activity.

European journal of medicinal chemistry Dec 29, 2017
Present work describes the in vitro antibacterial evaluation of some new amino acid conjugated antimicrobial drugs. Structural modification was attempted on the three existing antimicrobial pharmaceuticals namely trimethoprim, metronidazole, isoniazi...
Metronidazole Pseudomonas aeruginosa Dose-Response Relationship, Drug Bacillus Anti-Bacterial Agents Structure-Activity Relationship Salmonella typhi Isoniazid Microbial Sensitivity Tests Molecular Structure Hydrophobic and Hydrophilic Interactions Trimethoprim Escherichia coli Amino Acids Enzyme Inhibitors Staphylococcus aureus Urease
View on PubMed DOI

Design, synthesis, antibacterial evaluation and molecular docking studies of some new quinoxaline derivatives targeting dihyropteroate synthase enzyme.

Bioorganic chemistry Dec 5, 2017
Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. From this perspective, new quinoxaline derivatives bearing various bioactive heterocyclic moieties (thiadiazoles, oxadiazoles, pyrazoles and thiazoles) w...
Drug Design Hydrogen Bonding Molecular Structure Anti-Bacterial Agents Microbial Sensitivity Tests Hydrophobic and Hydrophilic Interactions Dihydropteroate Synthase Molecular Docking Simulation Protein Binding Catalytic Domain Quinoxalines Structure-Activity Relationship Gram-Negative Bacteria Levofloxacin Gram-Positive Bacteria Yersinia pestis
View on PubMed DOI

In silico identification of milk antihypertensive di- and tripeptides involved in angiotensin I-converting enzyme inhibitory activity.

Nutrition research (New York, N.Y.) Jul 28, 2017
Identification of bioactive milk peptides could improve food technology through improved selection of food supplements with a focus on antihypertensive properties. We hypothesized that angiotensin I-converting enzyme (ACE) inhibitory activities of mi...
Binding Sites Milk Proteins Quantitative Structure-Activity Relationship Protein Conformation Hydrogen Bonding Peptidyl-Dipeptidase A Proteolysis Dietary Supplements Antihypertensive Agents Models, Molecular Peptide Fragments Dipeptides Hydrophobic and Hydrophilic Interactions Expert Systems Catalytic Domain Oligopeptides Angiotensin-Converting Enzyme Inhibitors Humans Animals Molecular Docking Simulation Cattle Computational Biology
View on PubMed DOI

Design, preparation and characterization of pH-responsive prodrug micelles with hydrolyzable anhydride linkages for controlled drug delivery.

Journal of colloid and interface science Dec 31, 2016
We report a new prodrug micelle-based approach in which a model hydrophobic non-steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy polyethylene glycol-polypropylene fumarate (mPEG-PPF) diblock copolymer via ...
Humans Animals Nanoparticles Cell Line Cell Survival Solubility Hydrophobic and Hydrophilic Interactions Drug Carriers Drug Liberation Polypropylenes Anti-Inflammatory Agents, Non-Steroidal Micelles Surface Properties Rabbits Prodrugs Fumarates Ibuprofen Hydrogen-Ion Concentration HeLa Cells Anhydrides Polyethylene Glycols Hydrolysis
View on PubMed DOI

Controlled surface morphology and hydrophilicity of polycaprolactone toward human retinal pigment epithelium cells.

Materials science & engineering. C, Materials for biological applications Nov 24, 2016
Applying scaffolds as a bed to enhance cell proliferation and even differentiation is one of the treatment of retina diseases such as age-related macular degeneration (AMD) which deteriorating photoreceptors and finally happening blindness. In this s...
Retinal Pigment Epithelium Cell Shape Chloroform Keratins Immunohistochemistry Surface Properties Tissue Scaffolds Nanofibers Cell Adhesion Biocompatible Materials Hydrolysis Hydrophobic and Hydrophilic Interactions Polyesters Humans Infant, Newborn Water Porosity Microscopy, Fluorescence
View on PubMed DOI

TMSEG: Novel prediction of transmembrane helices.

Proteins Sep 16, 2016
Transmembrane proteins (TMPs) are important drug targets because they are essential for signaling, regulation, and transport. Despite important breakthroughs, experimental structure determination remains challenging for TMPs. Various methods have bri...
Databases, Protein Hydrophobic and Hydrophilic Interactions Datasets as Topic Humans Protein Conformation, alpha-Helical Machine Learning Sensitivity and Specificity Membrane Proteins
View on PubMed DOI
Popular Topics
Recent Journals