AIMC Topic: Hydrophobic and Hydrophilic Interactions

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Statistical moments in modelling of swelling, erosion and drug release of hydrophilic matrix-tablets.

International journal of pharmaceutics Feb 1, 2018
Statistical moments were evaluated as suitable parameters for describing swelling and erosion processes (along with drug release) in hydrophilic controlled release matrix tablets. The effect of four independent formulation variables, corresponding to...
Neural Networks, Computer Water Models, Statistical Drug Carriers Polymers Drug Compounding Linear Models Technology, Pharmaceutical Delayed-Action Preparations Nimodipine Kinetics Tablets Solubility Drug Liberation Hydrophobic and Hydrophilic Interactions
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A novel method for the production of core-shell microparticles by inverse gelation optimized with artificial intelligent tools.

International journal of pharmaceutics Jan 16, 2018
Numerous studies have been focused on hydrophobic compounds encapsulation as oils. In fact, oils can provide numerous health benefits as synergic ingredient combined with other hydrophobic active ingredients. However, stable microparticles for pharma...
Microspheres Glucuronic Acid Hexuronic Acids Calcium Chloride Sunflower Oil Fuzzy Logic Equipment Design Emulsions Hydrophobic and Hydrophilic Interactions Drug Compounding Gels Capsules Neural Networks, Computer Technology, Pharmaceutical Chemistry, Pharmaceutical Artificial Intelligence Alginates
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Amino acid conjugated antimicrobial drugs: Synthesis, lipophilicity- activity relationship, antibacterial and urease inhibition activity.

European journal of medicinal chemistry Dec 29, 2017
Present work describes the in vitro antibacterial evaluation of some new amino acid conjugated antimicrobial drugs. Structural modification was attempted on the three existing antimicrobial pharmaceuticals namely trimethoprim, metronidazole, isoniazi...
Metronidazole Dose-Response Relationship, Drug Bacillus Anti-Bacterial Agents Pseudomonas aeruginosa Structure-Activity Relationship Salmonella typhi Microbial Sensitivity Tests Isoniazid Molecular Structure Hydrophobic and Hydrophilic Interactions Escherichia coli Trimethoprim Amino Acids Enzyme Inhibitors Staphylococcus aureus Urease
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Design, synthesis, antibacterial evaluation and molecular docking studies of some new quinoxaline derivatives targeting dihyropteroate synthase enzyme.

Bioorganic chemistry Dec 5, 2017
Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. From this perspective, new quinoxaline derivatives bearing various bioactive heterocyclic moieties (thiadiazoles, oxadiazoles, pyrazoles and thiazoles) w...
Hydrophobic and Hydrophilic Interactions Catalytic Domain Gram-Negative Bacteria Gram-Positive Bacteria Hydrogen Bonding Dihydropteroate Synthase Anti-Bacterial Agents Drug Design Quinoxalines Molecular Docking Simulation Microbial Sensitivity Tests Levofloxacin Yersinia pestis Protein Binding Structure-Activity Relationship Molecular Structure
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In silico identification of milk antihypertensive di- and tripeptides involved in angiotensin I-converting enzyme inhibitory activity.

Nutrition research (New York, N.Y.) Jul 28, 2017
Identification of bioactive milk peptides could improve food technology through improved selection of food supplements with a focus on antihypertensive properties. We hypothesized that angiotensin I-converting enzyme (ACE) inhibitory activities of mi...
Humans Animals Molecular Docking Simulation Cattle Computational Biology Hydrophobic and Hydrophilic Interactions Expert Systems Catalytic Domain Oligopeptides Angiotensin-Converting Enzyme Inhibitors Dietary Supplements Antihypertensive Agents Models, Molecular Peptide Fragments Dipeptides Proteolysis Binding Sites Milk Proteins Quantitative Structure-Activity Relationship Protein Conformation Hydrogen Bonding Peptidyl-Dipeptidase A
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Design, preparation and characterization of pH-responsive prodrug micelles with hydrolyzable anhydride linkages for controlled drug delivery.

Journal of colloid and interface science Dec 31, 2016
We report a new prodrug micelle-based approach in which a model hydrophobic non-steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy polyethylene glycol-polypropylene fumarate (mPEG-PPF) diblock copolymer via ...
Humans Animals Nanoparticles Cell Line Cell Survival Drug Carriers Anti-Inflammatory Agents, Non-Steroidal Polypropylenes Surface Properties Ibuprofen Anhydrides Fumarates Drug Liberation Micelles Prodrugs HeLa Cells Hydrophobic and Hydrophilic Interactions Rabbits Hydrogen-Ion Concentration Polyethylene Glycols Hydrolysis Solubility
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Controlled surface morphology and hydrophilicity of polycaprolactone toward human retinal pigment epithelium cells.

Materials science & engineering. C, Materials for biological applications Nov 24, 2016
Applying scaffolds as a bed to enhance cell proliferation and even differentiation is one of the treatment of retina diseases such as age-related macular degeneration (AMD) which deteriorating photoreceptors and finally happening blindness. In this s...
Cell Shape Chloroform Keratins Surface Properties Tissue Scaffolds Nanofibers Cell Adhesion Retinal Pigment Epithelium Hydrolysis Hydrophobic and Hydrophilic Interactions Polyesters Immunohistochemistry Infant, Newborn Water Humans Porosity Microscopy, Fluorescence Biocompatible Materials
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TMSEG: Novel prediction of transmembrane helices.

Proteins Sep 16, 2016
Transmembrane proteins (TMPs) are important drug targets because they are essential for signaling, regulation, and transport. Despite important breakthroughs, experimental structure determination remains challenging for TMPs. Various methods have bri...
Membrane Proteins Databases, Protein Hydrophobic and Hydrophilic Interactions Datasets as Topic Protein Conformation, alpha-Helical Humans Machine Learning Sensitivity and Specificity
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Analytical approach to determining human biogenic amines and their metabolites using eVol microextraction in packed syringe coupled to liquid chromatography mass spectrometry method with hydrophilic interaction chromatography column.

Talanta Dec 21, 2015
Analysis of biogenic amines (BAs) in different human samples provides insight into the mechanisms of various biological processes, including pathological conditions, and thus may be very important in diagnosing and monitoring several neurological dis...
Reproducibility of Results Mass Spectrometry Chromatography, Liquid Hydrophobic and Hydrophilic Interactions Syringes Solid Phase Microextraction Biogenic Amines Humans
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Hydrophilic Ionic Liquids as Ingredients of Gel-Based Dermal Formulations.

AAPS PharmSciTech Oct 1, 2015
Ionic liquids (ILs) have several properties that offer many advantages in dermal drug delivery systems. Depending on the chemical structure, ILs can be used for protection against microorganisms, to enhance skin penetration, and as a solvent. In the ...
Solvents Gels Administration, Cutaneous Chemistry, Pharmaceutical Ions Ionic Liquids Emulsions Hydrophobic and Hydrophilic Interactions Drug Delivery Systems Animals Swine Imidazoles Skin
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