AIMC Topic: In Vitro Techniques

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Safer chemicals using less animals: kick-off of the European ONTOX project.

Toxicology
The 3Rs concept, calling for replacement, reduction and refinement of animal experimentation, is receiving increasing attention around the world, and has found its way to legislation, in particular in the European Union. This is aligned by continuing...

Converging global crises are forcing the rapid adoption of disruptive changes in drug discovery.

Drug discovery today
Spiralling research costs combined with urgent pressures from the Coronavirus 2019 (COVID-19) pandemic and the consequences of climate disruption are forcing changes in drug discovery. Increasing the predictive power of in vitro human assays and usin...

In Vitro Measurements of Shear-Mediated Platelet Adhesion Kinematics as Analyzed through Machine Learning.

Annals of biomedical engineering
Platelet adhesion to blood vessel walls in shear flow is essential to initiating the blood coagulation cascade and prompting clot formation in vascular disease processes and prosthetic cardiovascular devices. Validation of predictive adhesion kinemat...

Nanoemulsions and acidified milk gels as a strategy for improving stability and antioxidant activity of yarrow phenolic compounds after gastrointestinal digestion.

Food research international (Ottawa, Ont.)
The aim of this study was to improve the stability and antioxidant activity of yarrow phenolic compounds upon an in vitro simulated gastrointestinal digestion. Therefore, two types of caseins-based delivery systems, sodium caseinate stabilized nanoem...

Characterization of Nanoscale Organization of F-Actin in Morphologically Distinct Dendritic Spines Using Supervised Learning.

eNeuro
The cytoarchitecture of a neuron is very important in defining morphology and ultrastructure. Although there is a wealth of information on the molecular components that make and regulate these ultrastructures, there is a dearth of understanding of ho...

Deep convolutional neural networks for tongue squamous cell carcinoma classification using Raman spectroscopy.

Photodiagnosis and photodynamic therapy
With deep convolutional neural networks and fiber optic Raman spectroscopy, this study presents a novel classification method that discriminates tongue squamous cell carcinoma (TSCC) from non-tumorous tissue. To achieve this purpose, 24 tissues spect...

An In Vitro Study to Evaluate and Compare the Hemocompatibility of Titanium and Zirconia Implant Materials after Sandblasted and Acid-etched Surface Treatment.

The journal of contemporary dental practice
AIM: This study was aimed to investigate the hemocompatibility of zirconia and titanium implant materials after surface treatment with sandblasting and acid etching (SLA).

Effect of the in vitro gastrointestinal digestion on free-phenolic compounds and mono/oligosaccharides from Moringa oleifera leaves: Bioaccessibility, intestinal permeability and antioxidant capacity.

Food research international (Ottawa, Ont.)
Moringa oleifera is a plant recognized for its compounds such as dietary fiber (oligosaccharides, amongst others) and polyphenols, with biological activities. These properties depend on bioactive compounds (BC) interactions with food matrix/digestion...