AIMC Topic: Lung Neoplasms

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Exploring 4 generation EGFR inhibitors: A review of clinical outcomes and structural binding insights.

European journal of pharmacology
Epidermal growth factor receptor (EGFR) is a potential target for anticancer therapies and plays a crucial role in cell growth, survival, and metastasis. EGFR gene mutations trigger aberrant signaling, leading to non-small cell lung cancer (NSCLC). T...

Rapid dose prediction for lung CyberKnife radiotherapy plans utilizing a deep learning approach by incorporating dosimetric features delivered by noncoplanar beams.

Biomedical physics & engineering express
. The dose distribution of lung cancer patients treated with the CyberKnife (CK) system is influenced by various factors, including tumor location and the direction of CK beams. The objective of this study is to present a deep learning approach that ...

Virtual lung screening trial (VLST): An in silico study inspired by the national lung screening trial for lung cancer detection.

Medical image analysis
Clinical imaging trials play a crucial role in advancing medical innovation but are often costly, inefficient, and ethically constrained. Virtual Imaging Trials (VITs) present a solution by simulating clinical trial components in a controlled, risk-f...

MIST: An interpretable and flexible deep learning framework for single-T cell transcriptome and receptor analysis.

Science advances
Joint analysis of transcriptomic and T cell receptor (TCR) features at single-cell resolution provides a powerful approach for in-depth T cell immune function research. Here, we introduce a deep learning framework for single-T cell transcriptome and ...

An extension to the OVH concept for knowledge-based dose volume histogram prediction in lung tumor volumetric-modulated arc therapy.

Journal of applied clinical medical physics
PURPOSE: Volumetric-modulated arc therapy (VMAT) treatment planning allows a compromise between a sufficient coverage of the planning target volume (PTV) and a simultaneous sparing of organs-at-risk (OARs). Particularly in the case of lung tumors, de...

A Novel Theranostic Strategy for Malignant Pulmonary Nodules by Targeted CECAM6 with Zr/I-Labeled Tinurilimab.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Lung adenocarcinoma (LUAD) constitutes a major cause of cancer-related fatalities worldwide. Early identification of malignant pulmonary nodules constitutes the most effective approach to reducing the mortality of LUAD. Despite the wide application o...

Large Language Models in Summarizing Radiology Report Impressions for Lung Cancer in Chinese: Evaluation Study.

Journal of medical Internet research
BACKGROUND: Large language models (LLMs), such as ChatGPT, have demonstrated impressive capabilities in various natural language processing tasks, particularly in text generation. However, their effectiveness in summarizing radiology report impressio...

Analysis of Multiple Programmed Cell Death Patterns and Functional Validations of Apoptosis-Associated Genes in Lung Adenocarcinoma.

Annals of surgical oncology
BACKGROUND: Lung adenocarcinoma (LUAD) is marked by its considerable aggressiveness and pronounced heterogeneity. Programmed cell death (PCD) plays a pivotal role in the progression of tumors, their aggressive behavior, resistance to treatment, and r...

Prediction of PD-L1 expression in NSCLC patients using PET/CT radiomics and prognostic modelling for immunotherapy in PD-L1-positive NSCLC patients.

Clinical radiology
AIM: To develop a positron emission tomography/computed tomography (PET/CT)-based radiomics model for predicting programmed cell death ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) patients and estimating progression-free survival...