AIMC Topic: Macrophages
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Image based Machine Learning for identification of macrophage subsets.
Scientific reports
Jun 14, 2017
Macrophages play a crucial rule in orchestrating immune responses against pathogens and foreign materials. Macrophages have remarkable plasticity in response to environmental cues and are able to acquire a spectrum of activation status, best exemplif...
Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and in vivo biological properties.
European journal of medicinal chemistry
May 1, 2017
A new family of imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxide with antiproliferative Trypanosoma cruzi properties was identified from a neural network model published by our group. The synthesis and evaluation of this new class of trypanocidal agents ...
Hybrid-Actuating Macrophage-Based Microrobots for Active Cancer Therapy.
Scientific reports
Jun 27, 2016
Using macrophage recruitment in tumors, we develop active, transportable, cancer theragnostic macrophage-based microrobots as vector to deliver therapeutic agents to tumor regions. The macrophage-based microrobots contain docetaxel (DTX)-loaded poly-...
An immune-inspired swarm aggregation algorithm for self-healing swarm robotic systems.
Bio Systems
May 10, 2016
Swarm robotics is concerned with the decentralised coordination of multiple robots having only limited communication and interaction abilities. Although fault tolerance and robustness to individual robot failures have often been used to justify the u...
Investigation of the mutagenic and genotoxic activities of LLL-3, a STAT3 inhibitor.
Drug and chemical toxicology
Apr 10, 2016
LLL-3, an anthracene derived compound, has been shown to be a promising therapeutic agent for the treatment of some kinds of cancer such as chronic myeloid leukemia and glioblastoma. However, no data regarding the toxic properties of this compound ha...
Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways.
Environmental toxicology
May 26, 2015
Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially ...
Cytokines
Female
Middle Aged
Cell Migration Assays, Macrophage
Estradiol
Chemotaxis, Leukocyte
Diethylhexyl Phthalate
Tumor Necrosis Factor-alpha
Cells, Cultured
Humans
Phenols
Macrophages
Inflammation
Interleukin-1beta
Signal Transduction
NF-kappa B
Cell Movement
Benzhydryl Compounds
Lipopolysaccharides
Identification of biomarkers and immune infiltration associated with sexes in SSc: a bioinformatics and machine learning.
Rheumatology (Oxford, England)
Jun 1, 2025
OBJECTIVE: This study aimed to identify key candidate genes associated with the sexes of patients with SSc.
Integration of Bulk RNA and Single-Cell Analyses Reveal Distinct Expression Patterns of Anoikis-Related Genes and the Immunosuppressive Role of NQO1 Macrophages in Hepatocellular Carcinoma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
May 31, 2025
Anoikis resistance plays a crucial role in the proliferation, metastasis, and invasion of hepatocellular carcinoma (HCC). However, the key genes involved remain to be identified. This study aimed to investigate the prognostic value and impact of anoi...
Integrated machine learning survival framework develops a prognostic model based on macrophage-related genes and programmed cell death signatures in a multi-sample Kidney renal clear cell carcinoma.
Cell biology and toxicology
May 30, 2025
BACKGROUND: Macrophages are closely associated with the progression of Kidney renal clear cell carcinoma (KIRC) and can influence programmed cell death (PCD) of tumour cells. To identify prognostic biomarkers for KIRC, it is essential to investigate ...
Machine learning-based label-free macrophage phenotyping in immune-material interactions.
Journal of materials chemistry. B
May 21, 2025
The rapid advancement of implantable biomedical materials necessitates a comprehensive understanding of macrophage interactions to optimize implant immunocompatibility. Macrophages, key immune regulators, exhibit phenotypic plasticity by polarizing i...
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