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Longitudinal Model Shifts of Machine Learning-Based Clinical Risk Prediction Models: Evaluation Study of Multiple Use Cases Across Different Hospitals.

Journal of medical Internet research
BACKGROUND: In recent years, machine learning (ML)-based models have been widely used in clinical domains to predict clinical risk events. However, in production, the performances of such models heavily rely on changes in the system and data. The dyn...

Deep learning for segmentation of colorectal carcinomas on endoscopic ultrasound.

Techniques in coloproctology
BACKGROUND: Bowel-preserving local resection of early rectal cancer is less successful if the tumor infiltrates the muscularis propria as opposed to submucosal infiltration only. Magnetic resonance imaging currently lacks the spatial resolution to pr...

Real-World and Clinical Trial Validation of a Deep Learning Radiomic Biomarker for PD-(L)1 Immune Checkpoint Inhibitor Response in Advanced Non-Small Cell Lung Cancer.

JCO clinical cancer informatics
PURPOSE: This study developed and validated a novel deep learning radiomic biomarker to estimate response to immune checkpoint inhibitor (ICI) therapy in advanced non-small cell lung cancer (NSCLC) using real-world data (RWD) and clinical trial data.

A supervised machine learning statistical design of experiment approach to modeling the barriers to effective snakebite treatment in Ghana.

PLoS neglected tropical diseases
BACKGROUND: Snakebite envenoming is a serious condition that affects 2.5 million people and causes 81,000-138,000 deaths every year, particularly in tropical and subtropical regions. The World Health Organization has set a goal to halve the deaths an...

A clinical practical model for preoperative prediction of visual outcome for pituitary adenoma patients in a retrospective and prospective study.

Frontiers in endocrinology
OBJECTIVE: Preoperative prediction of visual recovery after pituitary adenoma resection surgery remains challenging. This study aimed to investigate the value of clinical and radiological features in preoperatively predicting visual outcomes after su...

IL-27 as a novel biomarker for pruritus in nodular prurigo and bullous pemphigoid.

Frontiers in immunology
INTRODUCTION: Bullous pemphigoid (BP) and prurigo nodularis (PN) are chronic pruritic skin diseases that severely impact patients' quality of life. Despite the widespread attention these two diseases have garnered within the dermatological field, the...

Development of a urine-based metabolomics approach for multi-cancer screening and tumor origin prediction.

Frontiers in immunology
BACKGROUND: Cancer remains a leading cause of mortality worldwide. A non-invasive screening solution was required for early diagnosis of cancer. Multi-cancer early detection (MCED) tests have been considered to address the challenge by simultaneously...

A machine learning approach for identifying anatomical biomarkers of early mild cognitive impairment.

PeerJ
BACKGROUND: Alzheimer's Disease (AD) poses a major challenge as a neurodegenerative disorder, and early detection is critical for effective intervention. Magnetic resonance imaging (MRI) is a critical tool in AD research due to its availability and c...

Random survival forest model for early prediction of Alzheimer's disease conversion in early and late Mild cognitive impairment stages.

PloS one
With a clinical trial failure rate of 99.6% for Alzheimer's Disease (AD), early diagnosis is critical. Machine learning (ML) models have shown promising results in early AD prediction, with survival ML models outperforming typical classifiers by prov...

Hybrid SEM-ANN model for predicting undergraduates' e-learning continuance intention based on perceived educational and emotional support.

PloS one
Based on the Expectation Confirmation Model (ECM), this study explores the impact of perceived educational and emotional support on university students' continuance intention to engage in e-learning. Researchers conducted a survey using structured qu...