AIMC Topic: Membrane Proteins
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TmDet 4.0: determining membrane orientation of transmembrane proteins from 3D structure.
Nucleic acids research
Jul 7, 2025
During the structural determination of transmembrane proteins, one crucial piece of information is lost: the orientation of the protein within the lipid bilayer. The TmDet algorithm was developed in the early 2000s to determine the relative position ...
Deep Learning Reveals Liver MRI Features Associated With PNPLA3 I148M in Steatotic Liver Disease.
Liver international : official journal of the International Association for the Study of the Liver
Jul 1, 2025
BACKGROUND: Steatotic liver disease (SLD) is the most common liver disease worldwide, affecting 30% of the global population. It is strongly associated with the interplay of genetic and lifestyle-related risk factors. The genetic variant accounting f...
Phage display enables machine learning discovery of cancer antigen-specific TCRs.
Science advances
Jun 13, 2025
T cells targeting epitopes in infectious diseases or cancer play a central role in spontaneous and therapy-induced immune responses. Epitope recognition is mediated by the binding of the T cell receptor (TCR), and TCRs recognizing clinically relevant...
Machine learning identifies SRD5A3 as a propionate-related prognostic biomarker in triple-negative breast cancer.
Scientific reports
May 29, 2025
The increased risk of recurrence and metastasis are obstacles to treating TNBC. Propionate-related genes play an important role in tumor development and immune cell infiltration. The study was to identify the association between propionate-related ge...
AI-designed antibody candidates hit a crucial target.
Science (New York, N.Y.)
May 15, 2025
Companies find enticing drug leads that bind to tricky cell membrane proteins.
Boi-Ogi-To, a Traditional Japanese Kampo Medicine, Promotes Cellular Excretion of Chloride and Water by Activating Volume-Sensitive Outwardly Rectifying Anion Channels.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
May 15, 2025
The Japanese Kampo medicine Boi-ogi-to (BOT) is known as an effective therapeutic agent for edema and nephrosis by promoting the excretion of excess body fluids. Despite its empirical effectiveness, scientific evidence supporting its effectiveness re...
Designer artificial environments for membrane protein synthesis.
Nature communications
May 10, 2025
Protein synthesis in natural cells involves intricate interactions between chemical environments, protein-protein interactions, and protein machinery. Replicating such interactions in artificial and cell-free environments can control the precision of...
Development of a prognostic model for osteosarcoma based on macrophage polarization-related genes using machine learning: implications for personalized therapy.
Clinical and experimental medicine
May 9, 2025
While neoadjuvant chemotherapy combined with surgical resection has improved the prognosis for patients with osteosarcoma, its impact on metastatic and recurrent cases remains limited. Immunotherapy is emerging as a promising alternative. However, th...
Exploring genetic and immune cell dynamics in systemic lupus erythematosus patients with Epstein-Barr virus infection via machine learning.
Rheumatology (Oxford, England)
May 1, 2025
OBJECTIVES: EBV is a widespread virus implicated in various diseases, including SLE. However, the specific genes and pathways altered in SLE patients with EBV infection remain unclear. We aimed to identify key genes and immune cells in SLE patients w...
Identification and validation of tissue-based gene biomarkers for acute intestinal graft-versus-host disease(AIGVHD).
Frontiers in immunology
Jan 1, 2025
BACKGROUND: Acute intestinal graft-versus-host disease (AIGVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (allo HSCT) with a high mortality rate. The primary aim of the present study is to identify tissue-based ge...
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