AIMC Topic: Mice, Inbred C57BL

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Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.

Cell Dec 16, 2020
Serotonin plays a central role in cognition and is the target of most pharmaceuticals for psychiatric disorders. Existing drugs have limited efficacy; creation of improved versions will require better understanding of serotonergic circuitry, which ha...
Brain Animals Protein Binding Mice Mice, Inbred C57BL Humans Machine Learning Algorithms HEK293 Cells Behavior, Animal Binding Sites Directed Molecular Evolution Serotonin Kinetics Amino Acid Sequence Wakefulness Sleep Linear Models Photons Amygdala Serotonin Plasma Membrane Transport Proteins
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Cellpose: a generalist algorithm for cellular segmentation.

Nature methods Dec 14, 2020
Many biological applications require the segmentation of cell bodies, membranes and nuclei from microscopy images. Deep learning has enabled great progress on this problem, but current methods are specialized for images that have large training datas...
Male Neural Networks, Computer Deep Learning Neurons Software Cell Nucleus Image Processing, Computer-Assisted Humans Algorithms Mice Female Mice, Inbred C57BL Animals
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Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.

Science (New York, N.Y.) Dec 10, 2020
Mapping the gene-regulatory networks dysregulated in human disease would allow the design of network-correcting therapies that treat the core disease mechanism. However, small molecules are traditionally screened for their effects on one to several o...
Mice Disease Models, Animal Mice, Inbred C57BL Calcinosis Aortic Valve Stenosis Animals Drug Discovery RNA-Seq Gene Regulatory Networks Small Molecule Libraries Induced Pluripotent Stem Cells Receptor, Notch1 Haploinsufficiency Aortic Valve Aortic Valve Disease Drug Evaluation, Preclinical Thiazoles Humans Gene Expression Regulation Machine Learning Nitriles Algorithms
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Impact of chronic intermittent hypoxia on the long non-coding RNA and mRNA expression profiles in myocardial infarction.

Journal of cellular and molecular medicine Nov 20, 2020
Chronic intermittent hypoxia (CIH) is the primary feature of obstructive sleep apnoea (OSA), a crucial risk factor for cardiovascular diseases. Long non-coding RNAs (lncRNAs) in myocardial infarction (MI) pathogenesis have drawn considerable attentio...
Animals Male Echocardiography Mice RNA, Messenger Disease Models, Animal Mice, Inbred C57BL RNA, Long Noncoding Blotting, Western Myocardial Infarction Hypoxia Gene Ontology
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Deep learning-enabled multi-organ segmentation in whole-body mouse scans.

Nature communications Nov 6, 2020
Whole-body imaging of mice is a key source of information for research. Organ segmentation is a prerequisite for quantitative analysis but is a tedious and error-prone task if done manually. Here, we present a deep learning solution called AIMOS that...
Animal Structures Lung Deep Learning Image Processing, Computer-Assisted Mice Mice, Inbred C57BL Brain Algorithms Kidney Liver Female Spleen Reproducibility of Results X-Ray Microtomography Animals Whole Body Imaging Male
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Deep Learning-Based Segmentation and Quantification in Experimental Kidney Histopathology.

Journal of the American Society of Nephrology : JASN Nov 5, 2020
BACKGROUND: Nephropathologic analyses provide important outcomes-related data in experiments with the animal models that are essential for understanding kidney disease pathophysiology. Precision medicine increases the demand for quantitative, unbiase...
Periodic Acid Mice Kidney Disease Models, Animal Mice, Inbred C57BL Kidney Diseases Kidney Glomerulus Translational Research, Biomedical Schiff Bases Pattern Recognition, Automated Animals Male Diagnosis, Computer-Assisted Deep Learning Image Processing, Computer-Assisted Neural Networks, Computer Algorithms Reproducibility of Results
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Machine learning-based data analytic approaches for evaluating post-natal mouse respiratory physiological evolution.

Respiratory physiology & neurobiology Sep 30, 2020
Respiratory parameters change during post-natal development, but the nature of their changes have not been well-described. The advent of commercially available plethysmographic instruments provided improved repeatability of measurements and standardi...
Tidal Volume Animals, Newborn Machine Learning Respiratory Physiological Phenomena Animals Respiratory System Mice Plethysmography Age Factors Mice, Inbred C57BL
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A machine learning approach for magnetic resonance image-based mouse brain modeling and fast computation in controlled cortical impact.

Medical & biological engineering & computing Sep 21, 2020
Computational modeling of the brain is crucial for the study of traumatic brain injury. An anatomically accurate model with refined details could provide the most accurate computational results. However, computational models with fine mesh details co...
Finite Element Analysis Animals Image Processing, Computer-Assisted Magnetic Resonance Imaging Brain Injuries Mice, Inbred C57BL Neural Networks, Computer Machine Learning Brain Computer Simulation
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A high throughput machine-learning driven analysis of Ca spatio-temporal maps.

Cell calcium Jul 28, 2020
High-resolution Ca imaging to study cellular Ca behaviors has led to the creation of large datasets with a profound need for standardized and accurate analysis. To analyze these datasets, spatio-temporal maps (STMaps) that allow for 2D visualization ...
Mice, Inbred C57BL Calcium Automation Interstitial Cells of Cajal Stochastic Processes Machine Learning Reproducibility of Results Animals Time Factors
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Deep learning-based classification of the mouse estrous cycle stages.

Scientific reports Jul 16, 2020
There is a rapidly growing demand for female animals in preclinical animal, and thus it is necessary to determine animals' estrous cycle stages from vaginal smear cytology. However, the determination of estrous stages requires extensive training, tak...
Area Under Curve Leukocytes Estrous Cycle Data Accuracy Vagina Vaginal Smears Mice Mice, Inbred C57BL Humans Epithelial Cells Neural Networks, Computer Female Adult Sensitivity and Specificity Animals Male Deep Learning ROC Curve
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