AIMC Topic: Mice, Inbred C57BL

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Kaempferol modulates Angiopoietin-like protein 2 expression to lessen the mastitis in mice.

Pharmacological reports : PR Nov 22, 2017
BACKGROUND: Mastitis is inflammation of a breast (or udder). Angiopoietin-like protein 2 (ANGPTL2) has been found as a key inflammatory mediator in mastitis. Purpose of this research was to investigate the mechanisms about repressing effect of kaempf...
Epithelial Cells Kaempferols Angiopoietin-like Proteins Peroxidase Angiopoietin-Like Protein 2 Tumor Necrosis Factor-alpha Interleukin-6 Female Animals Mice Mastitis Inflammation Mice, Inbred C57BL
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Sparse Supervised Classification Methods Predict and Characterize Nanomaterial Exposures: Independent Markers of MWCNT Exposures.

Toxicologic pathology Sep 22, 2017
Recent experimental evidence indicates significant pulmonary toxicity of multiwalled carbon nanotubes (MWCNTs), such as inflammation, interstitial fibrosis, granuloma formation, and carcinogenicity. Although numerous studies explored the adverse pote...
Mice Support Vector Machine Mice, Inbred C57BL Nanotubes, Carbon Bronchoalveolar Lavage Fluid Biomarkers Animals Male Lung
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A Machine Learning Approach to Automated Gait Analysis for the Noldus Catwalk System.

IEEE transactions on bio-medical engineering Aug 24, 2017
OBJECTIVE: Gait analysis of animal disease models can provide valuable insights into in vivo compound effects and thus help in preclinical drug development. The purpose of this paper is to establish a computational gait analysis approach for the Nold...
Pattern Recognition, Automated Machine Learning Gait Analysis Female Animals Foot Mice Oxidopamine Male Disease Models, Animal Signal Processing, Computer-Assisted Mice, Inbred C57BL Walking Gait Parkinsonian Disorders
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Identification of non-activated lymphocytes using three-dimensional refractive index tomography and machine learning.

Scientific reports Jul 27, 2017
Identification of lymphocyte cell types are crucial for understanding their pathophysiological roles in human diseases. Current methods for discriminating lymphocyte cell types primarily rely on labelling techniques with magnetic beads or fluorescenc...
Machine Learning Mice, Inbred C57BL Lymphocytes Refractometry Tomography Animals Lymphocyte Activation Single-Cell Analysis Mice
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Automated gesture tracking in head-fixed mice.

Journal of neuroscience methods Jul 17, 2017
BACKGROUND: The preparation consisting of a head-fixed mouse on a spherical or cylindrical treadmill offers unique advantages in a variety of experimental contexts. Head fixation provides the mechanical stability necessary for optical and electrophys...
Animals Locomotion Behavioral Research Supervised Machine Learning Image Interpretation, Computer-Assisted Head Behavior, Animal Male Gestures Mice Mice, Inbred C57BL
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A robot for high yield electrophysiology and morphology of single neurons in vivo.

Nature communications Jun 1, 2017
Single-cell characterization and perturbation of neurons provides knowledge critical to addressing fundamental neuroscience questions including the structure-function relationship and neuronal cell-type classification. Here we report a robot for effi...
Microelectrodes Electroporation Electrophysiological Phenomena Robotics Equipment Design Neurons Models, Animal Software Brain Female Animals Male Single-Cell Analysis Mice Mice, Inbred C57BL
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An unsupervised learning approach for tracking mice in an enclosed area.

BMC bioinformatics May 25, 2017
BACKGROUND: In neuroscience research, mouse models are valuable tools to understand the genetic mechanisms that advance evidence-based discovery. In this context, large-scale studies emphasize the need for automated high-throughput systems providing ...
Models, Animal Electronic Data Processing Behavior, Animal Social Behavior Animals Algorithms Mice Mice, Inbred C57BL Female Unsupervised Machine Learning
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Preparation of arginine-glycine-aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization.

International journal of nanomedicine Dec 30, 2016
Neovascularization (NV) of the cornea can disrupt visual function, causing ocular diseases, including blindness. Therefore, treatment of corneal NV has a high public health impact. Epigalloccatechin-3-gallate (EGCG), presenting antiangiogenesis effec...
Humans Animals Hyaluronic Acid Catechin Molecular Targeted Therapy Eye Burns Nanoparticles Cell Survival Oligopeptides Integrin alphaVbeta3 Angiogenesis Inhibitors Burns, Chemical Corneal Neovascularization Disease Models, Animal Human Umbilical Vein Endothelial Cells Mice, Inbred C57BL Ophthalmic Solutions
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Contralateral artery enlargement predicts carotid plaque progression based on machine learning algorithm models in apoE mice.

Biomedical engineering online Dec 28, 2016
BACKGROUND: This study specifically focused on anatomical MRI characterization of the low shear stress-induced atherosclerotic plaque in mice. We used machine learning algorithms to analyze multiple correlation factors of plaque to generate predictiv...
Apolipoproteins E Ultrasonography Mice Support Vector Machine Magnetic Resonance Imaging Ultrasonography, Doppler Carotid Arteries Plaque, Atherosclerotic Blood Flow Velocity Mice, Transgenic Machine Learning Algorithms Reproducibility of Results Mice, Inbred C57BL Decision Making Lipids Predictive Value of Tests Sensitivity and Specificity Animals Male Disease Progression
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An LC-MS/MS method for the determination of digitoxigenin in skin samples and its application to skin permeation and metabolic stability studies.

Journal of pharmaceutical and biomedical analysis Dec 23, 2016
An LC-MS/MS method was developed for the determination of digitoxigenin in mice skin samples. Chromatographic separation was achieved on an Agilent Poroshell 120 EC-C18 column. Mass spectrometric detection was achieved by a triple-quadrupole mass spe...
Skin Tandem Mass Spectrometry Permeability Drug Stability Calibration Digitoxigenin Swine Mice Mice, Inbred C57BL Chromatography, Liquid Reproducibility of Results Sensitivity and Specificity Animals
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