AIMC Topic: Mice

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An evaluation of selected (Q)SARs/expert systems for predicting skin sensitisation potential.

SAR and QSAR in environmental research Apr 20, 2018
Predictive testing to characterise substances for their skin sensitisation potential has historically been based on animal models such as the Local Lymph Node Assay (LLNA) and the Guinea Pig Maximisation Test (GPMT). In recent years, EU regulations, ...
Guinea Pigs Local Lymph Node Assay Dermatitis, Allergic Contact Animals Mice Structure-Activity Relationship Skin Expert Systems Quantitative Structure-Activity Relationship Animal Testing Alternatives
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Agonists of G-Protein-Coupled Odorant Receptors Are Predicted from Chemical Features.

The journal of physical chemistry letters Apr 17, 2018
Predicting the activity of chemicals for a given odorant receptor is a longstanding challenge. Here the activity of 258 chemicals on the human G-protein-coupled odorant receptor (OR)51E1, also known as prostate-specific G-protein-coupled receptor 2 (...
Humans Drug Evaluation, Preclinical Machine Learning Fatty Acids Animals Ligands Protein Binding Mice Receptors, Odorant Receptors, G-Protein-Coupled Neoplasm Proteins Models, Molecular
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Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy mouse model.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Apr 11, 2018
OBJECTIVE: To evaluate the impact of intravitreal (IV) and intraperitoneal (IP) astaxanthin (AST) injections on neovascular development (ND), retinal morphology, and apoptotic activity in a C57BL/6J mouse model with hyperoxia-induced retinopathy (HIR...
Microscopy, Electron Disease Models, Animal Fibrinolytic Agents Hyperoxia Animals Xanthophylls Oxygen Mice, Inbred BALB C In Situ Nick-End Labeling Mice Random Allocation Retina Apoptosis Intravitreal Injections Cell Proliferation Retinal Diseases Dose-Response Relationship, Drug Animals, Newborn
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Substrate stiffness affects neural network activity in an extracellular matrix proteins dependent manner.

Colloids and surfaces. B, Biointerfaces Mar 27, 2018
Neuronal growth, differentiation, extension, branching and neural network activity are strongly influenced by the mechanical property of extracellular matrix (ECM). However, the mechanism by which substrate stiffness regulates a neural network activi...
Neural Networks, Computer Animals Mice Calcium Dimethylpolysiloxanes Extracellular Matrix Tissue Engineering Extracellular Matrix Proteins
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Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical- Approach Combining Experiments and Machine Learning.

Frontiers in immunology Mar 20, 2018
Life-threatening cardiomyopathy is a severe, but common, complication associated with severe trauma or sepsis. Several signaling pathways involved in apoptosis and necroptosis are linked to trauma- or sepsis-associated cardiomyopathy. However, the un...
Cardiomyopathies Wounds and Injuries Cytochromes c Receptor-Interacting Protein Serine-Threonine Kinases Humans Myocytes, Cardiac Machine Learning Signal Transduction Cell Culture Techniques Algorithms Cells, Cultured Apoptosis Necrosis Animals Caspase 3 Sepsis Heparitin Sulfate Mice
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Resonance with subthreshold oscillatory drive organizes activity and optimizes learning in neural networks.

Proceedings of the National Academy of Sciences of the United States of America Mar 15, 2018
Network oscillations across and within brain areas are critical for learning and performance of memory tasks. While a large amount of work has focused on the generation of neural oscillations, their effect on neuronal populations' spiking activity an...
Rhodopsin Neurons Neural Networks, Computer Nerve Net Computer Simulation Ion Channels Animals Learning Mice Models, Neurological Action Potentials
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Disease Ontology: improving and unifying disease annotations across species.

Disease models & mechanisms Mar 12, 2018
Model organisms are vital to uncovering the mechanisms of human disease and developing new therapeutic tools. Researchers collecting and integrating relevant model organism and/or human data often apply disparate terminologies (vocabularies and ontol...
Gene Ontology Databases, Genetic Species Specificity Disease Molecular Sequence Annotation Animals Mice Rats
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Noninvasive detection of macrophage activation with single-cell resolution through machine learning.

Proceedings of the National Academy of Sciences of the United States of America Mar 6, 2018
We present a method enabling the noninvasive study of minute cellular changes in response to stimuli, based on the acquisition of multiple parameters through label-free microscopy. The retrieved parameters are related to different attributes of the c...
Models, Biological RAW 264.7 Cells Macrophage Activation Image Processing, Computer-Assisted Mice Machine Learning Progesterone Animals Spectrum Analysis, Raman Single-Cell Analysis Lipopolysaccharides Dose-Response Relationship, Drug Microscopy, Fluorescence
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Brain-specific functional relationship networks inform autism spectrum disorder gene prediction.

Translational psychiatry Mar 6, 2018
Autism spectrum disorder (ASD) is a neuropsychiatric disorder with strong evidence of genetic contribution, and increased research efforts have resulted in an ever-growing list of ASD candidate genes. However, only a fraction of the hundreds of nomin...
Humans Machine Learning Phenotype Autism Spectrum Disorder Rats Models, Genetic Databases, Genetic Genome Animals Mice Genomics Genetic Predisposition to Disease
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A machine learning approach for automated assessment of retinal vasculature in the oxygen induced retinopathy model.

Scientific reports Mar 2, 2018
Preclinical studies of vascular retinal diseases rely on the assessment of developmental dystrophies in the oxygen induced retinopathy rodent model. The quantification of vessel tufts and avascular regions is typically computed manually from flat mou...
Retinal Neovascularization Oxygen Retina Animals, Newborn Machine Learning Retinopathy of Prematurity Animals Mice
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