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Establishment of a prognostic model based on ER stress-related cell death genes and proposing a novel combination therapy in acute myeloid leukemia.
Journal of translational medicine
May 21, 2025
BACKGROUND: Acute myeloid leukemia (AML) is a highly heterogeneous malignancy, presenting significant challenges in accurately predicting patient prognosis. Dysregulation of endoplasmic reticulum (ER) stress and resistance to programmed cell death (P...
Association between atherogenicity indices and prediabetes: a 5-year retrospective cohort study in a general Chinese physical examination population.
Cardiovascular diabetology
May 21, 2025
BACKGROUND AND OBJECTIVE: Atherogenicity indices have emerged as promising markers for cardiometabolic disorders, yet their relationship with prediabetes risk remains unclear. This study aimed to comprehensively evaluate the associations between six ...
Development of a risk prediction model for secondary infection in severe/critical COVID-19 patients.
BMC infectious diseases
May 21, 2025
OBJECTIVE: This study aimed to develop a predictive model for secondary infections in patients with severe or critical COVID-19 by analyzing clinical characteristics and laboratory indicators.
Synthesizing [F]PSMA-1007 PET bone images from CT images with GAN for early detection of prostate cancer bone metastases: a pilot validation study.
BMC cancer
May 21, 2025
BACKGROUND: [F]FDG PET/CT scan combined with [F]PSMA-1007 PET/CT scan is commonly conducted for detecting bone metastases in prostate cancer (PCa). However, it is expensive and may expose patients to more radiation hazards. This study explores deep l...
Metabolic signature of COVID-19 progression: potential prognostic markers for severity and outcome.
Metabolomics : Official journal of the Metabolomic Society
May 21, 2025
INTRODUCTION: There are significant challenges remain in accurately categorizing the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients.
Imbalanced feature generation based on bootstrap power spectral curve for estimating respiratory rate.
Scientific reports
May 21, 2025
Rapid respiratory rate (RR) changes in older adults may indicate serious illness. Therefore, accurately estimating RR for cardiorespiratory fitness is essential. However, machine learning algorithm-related errors are unsuitable for medical decision-m...
Phase recognition in manual Small-Incision cataract surgery with MS-TCN + + on the novel SICS-105 dataset.
Scientific reports
May 21, 2025
Manual Small-Incision Cataract Surgery (SICS) is a prevalent technique in low- and middle-income countries (LMICs) but understudied with respect to computer assisted surgery. This prospective cross-sectional study introduces the first SICS video data...
The Effectiveness of a Chatbot Single-Session Intervention for People on Waitlists for Eating Disorder Treatment: Randomized Controlled Trial.
Journal of medical Internet research
May 21, 2025
BACKGROUND: Early treatment is critical for improving eating disorder prognosis. Single-session interventions (SSIs) can provide short-term support to people on waitlists for eating disorder treatment; however, it is not always possible to access SSI...
A Comparison of Responses from Human Therapists and Large Language Model-Based Chatbots to Assess Therapeutic Communication: Mixed Methods Study.
JMIR mental health
May 21, 2025
BACKGROUND: Consumers are increasingly using large language model-based chatbots to seek mental health advice or intervention due to ease of access and limited availability of mental health professionals. However, their suitability and safety for men...
Understanding Dermatologists' Acceptance of Digital Health Interventions: Cross-Sectional Survey and Cluster Analysis.
JMIR human factors
May 21, 2025
BACKGROUND: Digital health interventions (DHIs) have the potential to enhance dermatological care by improving quality, patient empowerment, and efficiency. However, adoption remains limited, particularly in Germany.
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