AIMC Topic: Mycobacterium tuberculosis

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Rapid microarray-based assay for detection of pyrazinamide resistant Mycobacterium tuberculosis.

Diagnostic microbiology and infectious disease Dec 30, 2018
Pyrazinamide (PZA) is a key antibiotic for the treatment of drug susceptible tuberculosis. PZA-resistance is mainly mediated by mutations in the pncA gene; however the current gold standard is a phenotypic drug susceptibility test requiring a well-ad...
Amidohydrolases Molecular Diagnostic Techniques Eswatini DNA, Bacterial Humans Microarray Analysis Antitubercular Agents Sensitivity and Specificity Pyrazinamide Tuberculosis, Multidrug-Resistant Time Factors Transition Temperature Mycobacterium tuberculosis Genotype
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Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance.

Nature communications Oct 17, 2018
Mycobacterium tuberculosis is a serious human pathogen threat exhibiting complex evolution of antimicrobial resistance (AMR). Accordingly, the many publicly available datasets describing its AMR characteristics demand disparate data-type analyses. He...
Drug Resistance, Bacterial Mycobacterium tuberculosis Gene Frequency Machine Learning Selection, Genetic Genome, Bacterial
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Towards better prediction of Mycobacterium tuberculosis lineages from MIRU-VNTR data.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases Jun 28, 2018
The determination of lineages from strain-based molecular genotyping information is an important problem in tuberculosis. Mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) typing is a commonly used molecular genotyp...
Computational Biology Tuberculosis Genetic Variation Mycobacterium tuberculosis Molecular Epidemiology Humans Machine Learning Phylogeny Databases, Nucleic Acid New York City Interspersed Repetitive Sequences Minisatellite Repeats
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Screening for active pulmonary tuberculosis: Development and applicability of artificial neural network models.

Tuberculosis (Edinburgh, Scotland) May 19, 2018
Tuberculosis (TB) remains a significant public health challenge, motivated by the diversity of healthcare epidemiological settings, as other factors. Cost-effective screening has substantial importance for TB control, demanding new diagnostic tools. ...
Humans Neural Networks, Computer Mycobacterium tuberculosis Risk Assessment Bacteriological Techniques Brazil Lung Prevalence Risk Factors Diagnosis, Computer-Assisted Decision Support Systems, Clinical Young Adult Mass Screening Decision Support Techniques Adult Predictive Value of Tests Databases, Factual Male Sputum Female Middle Aged Tuberculosis, Pulmonary Reproducibility of Results
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hexanic extract displays  synergistic antibacterial activity against .

Natural product research Dec 25, 2017
A phytochemical and antibacterial study of , a species endemic to Mexico, was performed allowing the isolation of six flavones. The minimal inhibitory concentration (MIC) of the hexanic extract, against H37Rv was 25 μg/mL. The hexanic extract cause...
Flavones Microbial Sensitivity Tests Plant Extracts Mexico Antitubercular Agents Mycobacterium tuberculosis Drug Synergism Hexanes Asteraceae
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Evaluation of a Urine-Based Rapid Molecular Diagnostic Test with Potential to Be Used at Point-of-Care for Pulmonary Tuberculosis: Cape Town Cohort.

The Journal of molecular diagnostics : JMD Dec 18, 2017
Tuberculosis (TB) diagnosis among sputum-scarce patients is time consuming. Thus, a nonsputum diagnostic alternative is urgently needed. The Mycobacterium tuberculosis-specific transrenal (Tr) DNA from urine is a potential target for TB diagnostics. ...
Aged, 80 and over Young Adult Adult Sensitivity and Specificity Cross-Sectional Studies Male Point-of-Care Systems Middle Aged HIV Infections Cohort Studies Humans Biomarkers Female Risk Factors Aged Polymerase Chain Reaction South Africa Multivariate Analysis Microscopy Molecular Diagnostic Techniques Tuberculosis, Pulmonary DNA, Bacterial Mycobacterium tuberculosis Logistic Models Diagnostic Tests, Routine Universities Sputum
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A multicentre verification study of the QuantiFERON-TB Gold Plus assay.

Tuberculosis (Edinburgh, Scotland) Nov 28, 2017
OBJECTIVES: The aim of this verification study was to compare the QuantiFERON-TB Gold Plus (QFT-Plus) to the QuantiFERON-TB Gold In Tube (QFT-GIT). The new QFT-Plus test contains an extra antigen tube which, according to the manufacturer additionally...
Netherlands Antigens, Bacterial Middle Aged Host-Pathogen Interactions Interferon-gamma Release Tests Humans CD8-Positive T-Lymphocytes Interferon-gamma Female Predictive Value of Tests Latent Tuberculosis Reproducibility of Results CD4-Positive T-Lymphocytes Belgium Adult Mycobacterium tuberculosis Male
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Acquaintance to Artificial Neural Networks and use of artificial intelligence as a diagnostic tool for tuberculosis: A review.

Tuberculosis (Edinburgh, Scotland) Sep 20, 2017
Tuberculosis [TB] has afflicted numerous nations in the world. As per a report by the World Health Organization [WHO], an estimated 1.4 million TB deaths in 2015 and an additional 0.4 million deaths resulting from TB disease among people living with ...
Tuberculosis Mycobacterium tuberculosis Early Diagnosis Biomarkers Host-Pathogen Interactions Reproducibility of Results Humans Diagnosis, Computer-Assisted Neural Networks, Computer Fuzzy Logic Decision Support Techniques Predictive Value of Tests
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Machine learning and docking models for Mycobacterium tuberculosis topoisomerase I.

Tuberculosis (Edinburgh, Scotland) Jan 20, 2017
There is a shortage of compounds that are directed towards new targets apart from those targeted by the FDA approved drugs used against Mycobacterium tuberculosis. Topoisomerase I (Mttopo I) is an essential mycobacterial enzyme and a promising target...
Computer-Aided Design Drug Design Dose-Response Relationship, Drug Structure-Activity Relationship Bayes Theorem Humans Machine Learning Molecular Docking Simulation Mycobacterium smegmatis DNA Topoisomerases, Type I Topoisomerase I Inhibitors Antitubercular Agents Tuberculosis Mycobacterium tuberculosis Molecular Targeted Therapy Protein Conformation
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Artificial Intelligence and Amikacin Exposures Predictive of Outcomes in Multidrug-Resistant Tuberculosis Patients.

Antimicrobial agents and chemotherapy Sep 23, 2016
Aminoglycosides such as amikacin continue to be part of the backbone of treatment of multidrug-resistant tuberculosis (MDR-TB). We measured amikacin concentrations in 28 MDR-TB patients in Botswana receiving amikacin therapy together with oral levofl...
Amikacin Botswana Middle Aged Microbial Sensitivity Tests Adolescent Models, Theoretical Treatment Outcome Regression Analysis Antitubercular Agents Tuberculosis, Multidrug-Resistant Tuberculosis, Pulmonary Mycobacterium tuberculosis Aged Aged, 80 and over Young Adult Adult Humans Male Artificial Intelligence Female
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