AIMC Topic: Oxidative Stress

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Exploring the role of oxidative stress in retinal vein occlusion: an updated and comprehensive review on the pathophysiology and treatment perspectives.

International ophthalmology
INTRODUCTION: Retinal vein occlusion (RVO) represents a prevalent cause of vision impairment within retinal vascular diseases. Although hypoperfusion and inflammation are recognized pathogenic contributors, emerging evidence highlights oxidative stre...

Cuproptosis induced by curcumin interfering with proliferation and energy metabolism in colorectal cancer: 3D tumor model and computational simulations reveal curcumin inhibition of HSPD1 and CALCOCO2.

European journal of pharmacology
PURPOSE: Colorectal cancer is a highly aggressive malignancy characterized by complex tumor micro-environments and significant drug resistance. We highlighted the critical role of curcumin in inhibiting tumor growth and migration, inducing cuproptosi...

Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing data.

Biology direct
BACKGROUND: Oxidative stress plays a crucial role in the development of diabetic foot ulcers (DFU). However, its underlying mechanisms are not fully understood. The purpose of this study was to use bioinformatics and preliminary validation methods to...

Identification and verification of immune and oxidative stress-related diagnostic indicators for malignant lung nodules through WGCNA and machine learning.

Scientific reports
Early detection of lung nodules (LNs) is critical for prevention and treatment of lung cancer. However, current noninvasive diagnostic methods face significant challenges in reliably distinguishing benign from malignant nodules. Thus, there is an urg...

Machine learning reveals genes impacting oxidative stress resistance across yeasts.

Nature communications
Reactive oxygen species (ROS) are highly reactive molecules encountered by yeasts during routine metabolism and during interactions with other organisms, including host infection. Here, we characterize the variation in resistance to the ROS-inducing ...

Protective effects of minocycline on dermal fibroblast cells from oxidant and apoptotic effects of HO: A comprehensive analysis with Raman spectroscopy and data-driven approach.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Minocycline (Mino) is an antibiotic with neuroprotective, anti-inflammatory, and antioxidant properties. This study investigated the protective effects of Mino against hydrogen peroxide (HO)-induced oxidative damage in dermal fibroblast cells and ana...

Transcriptomic bioinformatics analysis proposes a novel BCL2-MAPK14-TXN oxidative stress diagnostic model of sepsis and identifies TXN as an oxidative stress-related signature gene in sepsis.

International immunopharmacology
BACKGROUND: Oxidative stress was one of key factors driving the septic development by the uncontrolled accumulation of free radicals, thus oxidative stress-related biomarkers provide a novel diagnostic option. This study focused on screening oxidativ...

From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics.

Cell biology and toxicology
The brain growth spurt (BGS) represents a pivotal window in neurodevelopment, defined by rapid neurogenesis, heightened synaptogenesis, and the dynamic establishment of neural networks. During this phase, heightened brain plasticity significantly enh...

Impact of e-waste pollutant exposure on renal injury and oxidative stress biomarkers: Evidence from causal machine learning.

Journal of hazardous materials
Global electronification has driven an unprecedented surge in electronic and electrical waste (e-waste), with approximately 75 % of this e-waste informally managed, releasing hazardous chemicals. Traditional association analyses have limited ability ...

An integrated analytical approach for biomarker discovery in esophageal cancer: Combining trace element and oxidative stress profiling with machine learning.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
BACKGROUND: Early detection of esophageal squamous cell carcinoma (ESCC) significantly improves survival rates, yet reliable biochemical biomarkers for early diagnosis remain limited. The aim of this study is to identify potential early diagnostic bi...