AIMC Topic: Oxidative Stress
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Niuhuang jiedu prescription alleviates realgar-induced dopaminergic and GABAergic neurotoxicity in Caenorhabditis elegans.
Journal of ethnopharmacology
Apr 2, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: Niuhuang Jiedu (NHJD) is a Chinese medicine prescription containing realgar (AsS), which is neurotoxic, and seven other traditional Chinese medicines (TCMs). However, whether the multiple TCMs contained in NHJD can mit...
Antioxidant activity of Mentha piperita phenolics on arsenic induced oxidative stress, biochemical alterations, and cyto-genotoxicity in fish, Channa punctatus.
Fish physiology and biochemistry
Mar 20, 2025
The study aims to investigate the synergistic antioxidant effects of the phenolics present in Mentha piperita (MP) against arsenic trioxide-induced oxidative stress, biochemical alteration, and cyto-genotoxicity in the fish, Channa punctatus. The phe...
Role of oxidative balance score in staging and mortality risk of cardiovascular-kidney-metabolic syndrome: Insights from traditional and machine learning approaches.
Redox biology
Mar 7, 2025
OBJECTIVES: To evaluate the roles of oxidative balance score (OBS) in staging and mortality risk of cardiovascular-kidney-metabolic syndrome (CKM).
Involvement of disulfidptosis in the pathophysiology of autism spectrum disorder.
Life sciences
Mar 5, 2025
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, with oxidative stress recognized as a key pathogenic mechanisms. Oxidative stress disrupts intracellular dynamic- thiol/disulfide homeostasis (DTDH), potentially leading to disu...
Identification of benzo(a)pyrene-related toxicological targets and their role in chronic obstructive pulmonary disease pathogenesis: a comprehensive bioinformatics and machine learning approach.
BMC pharmacology & toxicology
Feb 17, 2025
BACKGROUND: Chronic obstructive pulmonary disease (COPD) pathogenesis is influenced by environmental factors, including Benzo(a)pyrene (BaP) exposure. This study aims to identify BaP-related toxicological targets and elucidate their roles in COPD dev...
Integration of single-cell and bulk RNA sequencing data using machine learning identifies oxidative stress-related genes LUM and PCOLCE2 as potential biomarkers for heart failure.
International journal of biological macromolecules
Feb 8, 2025
Oxidative stress (OS) is a pivotal mechanism driving the progression of cardiovascular diseases, particularly heart failure (HF). However, the comprehensive characterisation of OS-related genes in HF remains largely unexplored. In the present study, ...
Automated and explainable machine learning for monitoring lipid and protein oxidative damage in mutton using hyperspectral imaging.
Food research international (Ottawa, Ont.)
Feb 1, 2025
Current detection methods for lipid and protein oxidation using hyperspectral imaging (HSI) in conjunction with machine learning (ML) necessitate the involvement of data scientists and domain experts to adjust the model architecture and tune hyperpar...
Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning.
Biology direct
Jan 29, 2025
BACKGROUND: Carotid atherosclerotic plaque is the primary cause of cardiovascular and cerebrovascular diseases. It is closely related to oxidative stress and immune inflammation. This bioinformatic study was conducted to identify key oxidative stress...
Plasma IL-17A is increased in patients with critical MIS-C and associated to in-hospital mortality.
Frontiers in immunology
Jan 27, 2025
BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe post-COVID-19 complication with multiple phenotypes.
Physalis Calyx seu Fructus relieves chicken intestinal damage to heat via improving the antioxidant ability.
Frontiers in immunology
Jan 14, 2025
Heat-stress-induced oxidative and inflammatory responses were important factors contributing to chicken intestinal damage. The purpose of this study was based on the antioxidant and anti-inflammatory activities of Physalis Calyx seu Fructus (Jin Deng...
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