AIMC Topic: Oxidative Stress

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Conformational changes of β-thalassemia major hemoglobin and oxidative status of plasma after in vitro exposure to extremely low-frequency electromagnetic fields: An artificial neural network analysis.

Electromagnetic biology and medicine Oct 23, 2020
Electromagnetic fields (EMF) can generate reactive oxygen species and induce oxidative modifications. We investigated the effects of extremely low-frequency electromagnetic fields (ELF-EMF) on oxidative status of plasma and erythrocytes in β-thalasse...
Hemoglobins beta-Thalassemia Protein Conformation Electromagnetic Fields Humans Neural Networks, Computer Oxidative Stress Oxidation-Reduction
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Virgin Coconut Oil-Induced Neuroprotection in Lipopolysaccharide-Challenged Rats is Mediated, in Part, Through Cholinergic, Anti-Oxidative and Anti-Inflammatory Pathways.

Journal of dietary supplements Oct 14, 2020
Neuroinflammation is associated with neuronal cell death and could lead to chronic neurodegeneration. This study investigated the neuroprotective potential of virgin coconut oil (VCO) against lipopolysaccharide (LPS)-induced cytotoxicity of neuroblas...
Acetylcholinesterase Rats Neuroprotection Cholinergic Agents Lipopolysaccharides Coconut Oil Animals Anti-Inflammatory Agents Oxidative Stress Rats, Wistar
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High spatially sensitive quantitative phase imaging assisted with deep neural network for classification of human spermatozoa under stressed condition.

Scientific reports Aug 4, 2020
Sperm cell motility and morphology observed under the bright field microscopy are the only criteria for selecting a particular sperm cell during Intracytoplasmic Sperm Injection (ICSI) procedure of Assisted Reproductive Technology (ART). Several fact...
Ethanol Spermatozoa Microscopy Signal-To-Noise Ratio Oxidative Stress Image Processing, Computer-Assisted Cryopreservation Humans Male Deep Learning Hydrogen Peroxide
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Sulodexide modulates the dialysate effect on the peritoneal mesothelium.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Mar 20, 2020
Peritoneal membrane damage during chronic peritoneal dialysis is the main cause of that treatment failure. Preservation of the mesothelial cells (MC) is important for the survival of the peritoneum. Evaluation of dialysates effect on the function of ...
Humans Peritoneal Dialysis, Continuous Ambulatory Dialysis Solutions Cells, Cultured Peritoneum Epithelium Oxidative Stress Glycosaminoglycans Anticoagulants Gene Expression Regulation
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Discovery of Small-Molecule Activators for Glucose-6-Phosphate Dehydrogenase (G6PD) Using Machine Learning Approaches.

International journal of molecular sciences Feb 23, 2020
Glucose-6-Phosphate Dehydrogenase (G6PD) is a ubiquitous cytoplasmic enzyme converting glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway (PPP). The G6PD deficiency renders the inability to regenerate glutathione due to lack...
Machine Learning Animals Molecular Docking Simulation Drug Discovery Humans Protein Interaction Domains and Motifs Glucosephosphate Dehydrogenase NADP Pentose Phosphate Pathway Drug Evaluation, Preclinical Catalytic Domain Glutathione X-Ray Diffraction Oxidative Stress Oxidation-Reduction Glucosephosphate Dehydrogenase Deficiency
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Antioxidant and Anti-inflammatory Diagnostic Biomarkers in Multiple Sclerosis: A Machine Learning Study.

Molecular neurobiology Jan 22, 2020
An imbalance of inflammatory/anti-inflammatory and oxidant/antioxidant molecules has been implicated in the demyelination and axonal damage in multiple sclerosis (MS). The current study aimed to evaluate the plasma levels of tumor necrosis factor (TN...
Oxidation-Reduction Sulfhydryl Compounds Multiple Sclerosis Adiponectin Nitric Oxide Inflammation Support Vector Machine Advanced Oxidation Protein Products Nitrosative Stress Receptors, Tumor Necrosis Factor Biomarkers Female Adult Sensitivity and Specificity Male Middle Aged Oxidative Stress Antioxidants Humans Neural Networks, Computer Tumor Necrosis Factor-alpha
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Inhibition to crucial enzymes in the lethal effects of the dinoflagellate Karenia mikimotoi on the rotifer Brachionus plicatilis.

Marine environmental research Dec 21, 2019
Blooms of the dinoflagellate Karenia mikimotoi have cause great financial losses to the marine aquaculture industry. However, the toxicity mechanism of this species is still not fully known. In this study, we evaluated the short-term effects of K. mi...
Animals Harmful Algal Bloom Oxidative Stress Rotifera Aquaculture Adenosine Triphosphatases Sodium-Potassium-Exchanging ATPase Dinoflagellida
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Mesoporous cobalt monoxide-supported platinum nanoparticles: Superior catalysts for the oxidative removal of benzene.

Journal of environmental sciences (China) Dec 9, 2019
Mesoporous CoO (meso-CoO)-supported Pt (0.53 wt.% Pt/meso-CoO) was synthesized via the KIT-6-templating and polyvinyl alcohol (PVA)-assisted reduction routes. Mesoporous CoO (meso-CoO) was fabricated through in situ reduction of meso-CoO with glycero...
Cobalt Oxidative Stress Benzene Metal Nanoparticles Models, Chemical Platinum
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Validation of oxidative stress assay for schizophrenia.

Schizophrenia research Aug 6, 2019
Accumulating evidence implicates oxidative stress in a range of diseases, yet no objective measurement has emerged that characterizes the global nature of oxidative stress. Previously, we reported a measurement that employs the moderately strong oxid...
Iridium Machine Learning Biomarkers ROC Curve Female Biological Assay Reproducibility of Results Schizophrenia Adult Humans Male Middle Aged Oxidative Stress
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Disability in multiple sclerosis is associated with age and inflammatory, metabolic and oxidative/nitrosative stress biomarkers: results of multivariate and machine learning procedures.

Metabolic brain disease Jul 13, 2019
The aim of this study was to evaluate the immune-inflammatory, metabolic, and nitro-oxidative stress (IM&NO) biomarkers as predictors of disability in multiple sclerosis (MS) patients. A total of 122 patients with MS were included; their disability w...
Female Adult Male Middle Aged Oxidative Stress Inflammation Body Mass Index Age Factors Multiple Sclerosis Humans Cholesterol, HDL Machine Learning Nitrosative Stress Disability Evaluation Biomarkers Uric Acid Homocysteine
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