AIMC Topic: Parkinson Disease
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Exploring the mechanism of metabolic cell death-related genes AKR1C2 and MAP1LC3A as biomarkers in Parkinson's disease.
Scientific reports
Jul 15, 2025
There is a strong relationship between metabolic cell death (MCD) and neurodegenerative diseases. However, the involvement of metabolic cell death (MCD)-related genes (MCDRGs) in Parkinson's disease (PD) pathogenesis remains poorly analyzed. Integrat...
Finger drawing on smartphone screens enables early Parkinson's disease detection through hybrid 1D-CNN and BiGRU deep learning architecture.
PloS one
Jul 14, 2025
BACKGROUND: Parkinson's disease (PD), a progressive neurodegenerative disorder prevalent in aging populations, manifests clinically through characteristic motor impairments including bradykinesia, rigidity, and resting tremor. Early detection and tim...
Enhancing Parkinson's disease prediction using meta-heuristic optimized machine learning models.
Personalized medicine
Jul 11, 2025
Parkinson's disease is a progressive neurological disorder affecting movement and cognition. Early detection is crucial but challenging with traditional methods. This study applies meta-heuristic optimization to enhance machine learning prediction mo...
Assessing changes in whole-brain structural connectivity in the unilateral 6-hydroxydopamine rat model of Parkinson's disease using diffusion imaging and tractography.
Journal of neural engineering
Jul 7, 2025
Parkinson's disease (PD) is a multifactorial, progressive neurodegenerative disease that has a profound impact on those it afflicts. Its hallmark pathophysiology is characterized by degeneration of dopaminergic (DA) neurons in the midbrain which trig...
Brain structural features with functional priori to classify Parkinson's disease and multiple system atrophy using diagnostic MRI.
Scientific reports
Jul 1, 2025
Clinical two-dimensional (2D) MRI data has seen limited application in the early diagnosis of Parkinson's disease (PD) and multiple system atrophy (MSA) due to quality limitations, yet its diagnostic and therapeutic potential remains underexplored. T...
Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.
Nature communications
Jul 1, 2025
Extracellular vesicles (EVs) in plasma are composed of exosomes, microvesicles, and apoptotic bodies. We report a plasma EV enrichment strategy using magnetic beads called Mag-Net. Proteomic interrogation of this plasma EV fraction enables the detect...
Proteomic risk scores for predicting common diseases using linear and neural network models in the UK biobank.
Scientific reports
Jul 1, 2025
Plasma proteomics provides a unique opportunity to enhance disease prediction by capturing protein expression patterns linked to diverse pathological processes. Leveraging data from 2,923 proteins measured in 53,030 UK Biobank participants, we develo...
Design of a deep fusion model for early Parkinson's disease prediction using handwritten image analysis.
Scientific reports
Jul 1, 2025
Parkinson's Disease (PD) is a deteriorating condition that mostly affects older people. The lack of conclusive treatment for PD makes diagnosis very challenging. However, using patterns like tremors for early diagnosis, handwriting analysis has becom...
Ultradeep N-glycoproteome atlas of mouse reveals spatiotemporal signatures of brain aging and neurodegenerative diseases.
Nature communications
Jul 1, 2025
The current depth of site-specific N-glycoproteomics is insufficient to fully characterize glycosylation events in biological samples. Herein, we achieve an ultradeep and precision analysis of the N-glycoproteome of mouse tissues by integrating multi...
Subthalamic nucleus or globus pallidus internus deep brain stimulation for the treatment of parkinson's disease: An artificial intelligence approach.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Jun 18, 2025
BACKGROUND: Generative artificial intelligence (AI) in deep brain stimulation (DBS) is currently unvalidated in its content. This study sought to analyze AI responses to questions and recommendations from the 2018 Congress of Neurological Surgeons (C...
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