Proceedings of the National Academy of Sciences of the United States of America
Nov 5, 2020
The prefrontal cortex encodes and stores numerous, often disparate, schemas and flexibly switches between them. Recent research on artificial neural networks trained by reinforcement learning has made it possible to model fundamental processes underl...
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
Oct 14, 2020
BACKGROUND: Theoretical and empirical work suggest that addictive drugs potentiate dopaminergic reinforcement learning signals and disrupt the reward function of its neural targets, including the anterior midcingulate cortex (aMCC) and the basal gang...
Neural networks : the official journal of the International Neural Network Society
Sep 19, 2020
Learning to select appropriate actions based on their values is fundamental to adaptive behavior. This form of learning is supported by fronto-striatal systems. The dorsal-lateral prefrontal cortex (dlPFC) and the dorsal striatum (dSTR), which are st...
Cognition involves using attended information, maintained in working memory (WM), to guide action. During a cognitive task, a correct response requires flexible, selective gating so that only the appropriate information flows from WM to downstream ef...
This study quantified eight small-molecule neurotransmitters collected simultaneously from prefrontal cortex of C57BL/6J mice ( = 23) during wakefulness and during isoflurane anesthesia (1.3%). Using isoflurane anesthesia as an independent variable e...
Motivation plays a central role in human behavior and cognition but is not well captured by widely used artificial intelligence (AI) and computational modeling frameworks. This Opinion article addresses two central questions regarding the nature of m...
Separating neural signals from noise can improve brain-computer interface performance and stability. However, most algorithms for separating neural action potentials from noise are not suitable for use in real time and have shown mixed effects on dec...
Frontal Eye Field (FEF) neurons discriminate between relevant and irrelevant visual stimuli and their response magnitude predicts conscious perception. How this is reflected in the spatial representation of a visual stimulus at the neuronal populatio...
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Dec 16, 2019
Understanding how the brain forms representations of structured information distributed in time is a challenging endeavour for the neuroscientific community, requiring computationally and neurobiologically informed approaches. The neural mechanisms f...
Chronic and recurrent opiate use injuries brain tissue and cause serious pathophysiological changes in hemodynamic and subsequent inflammatory responses. Prefrontal cortex (PFC) has been implicated in drug addiction. However, the mechanism underlying...
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