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Radiopharmaceuticals

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Detection of transient neurotransmitter response using personalized neural networks.

Physics in medicine and biology
Measurement of stimulus-induced dopamine release and other types of transient neurotransmitter response (TNR) from dynamic positron emission tomography (PET) images typically suffers from limited detection sensitivity and high false positive (FP) rat...

Multi-institutional Retrospective Validation and Comparison of the Simplified PADUA REnal Nephrometry System for the Prediction of Surgical Success of Robot-assisted Partial Nephrectomy.

European urology focus
BACKGROUND: The use of a nephron-sparing surgery for the treatment of localized renal masses is being pushed to more challenging cases. However, this procedure is not devoid of risks, and the Radius, Exophytic/Endophytic, Nearness, Anterior/Posterior...

Comparison of 11 automated PET segmentation methods in lymphoma.

Physics in medicine and biology
Segmentation of lymphoma lesions in FDG PET/CT images is critical in both assessing individual lesions and quantifying patient disease burden. Simple thresholding methods remain common despite the large heterogeneity in lymphoma lesion location, size...

Machine learning-based FDG PET-CT radiomics for outcome prediction in larynx and hypopharynx squamous cell carcinoma.

Clinical radiology
AIM: To determine whether machine learning-based radiomic feature analysis of baseline integrated 2-[F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET) computed tomography (CT) predicts disease progression in patients with locally a...

Approximating anatomically-guided PET reconstruction in image space using a convolutional neural network.

NeuroImage
In the last two decades, it has been shown that anatomically-guided PET reconstruction can lead to improved bias-noise characteristics in brain PET imaging. However, despite promising results in simulations and first studies, anatomically-guided PET ...

Feasibility of Multiparametric Positron Emission Tomography/Magnetic Resonance Imaging as a One-Stop Shop for Radiation Therapy Planning for Patients with Head and Neck Cancer.

International journal of radiation oncology, biology, physics
PURPOSE: Multiparametric positron emission tomography (PET)/magnetic resonance imaging (MRI) as a one-stop shop for radiation therapy (RT) planning has great potential but is technically challenging. We studied the feasibility of performing multipara...

Application of Deep Learning to Predict Standardized Uptake Value Ratio and Amyloid Status on F-Florbetapir PET Using ADNI Data.

AJNR. American journal of neuroradiology
BACKGROUND AND PURPOSE: Cortical amyloid quantification on PET by using the standardized uptake value ratio is valuable for research studies and clinical trials in Alzheimer disease. However, it is resource intensive, requiring co-registered MR imagi...

Deep learning-guided joint attenuation and scatter correction in multitracer neuroimaging studies.

Human brain mapping
PET attenuation correction (AC) on systems lacking CT/transmission scanning, such as dedicated brain PET scanners and hybrid PET/MRI, is challenging. Direct AC in image-space, wherein PET images corrected for attenuation and scatter are synthesized f...

Radiogenomic Models Using Machine Learning Techniques to Predict EGFR Mutations in Non-Small Cell Lung Cancer.

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
BACKGROUND: The purpose of this study was to build radiogenomics models from texture signatures derived from computed tomography (CT) and F-FDG PET-CT (FDG PET-CT) images of non-small cell lung cancer (NSCLC) with and without epidermal growth factor ...