AIMC Topic: Rats, Sprague-Dawley

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Mesenchymal stem cell transplantation ameliorates inflammation in spinal cord injury by inhibiting lactylation-related genes.

Cytokine
BACKGROUND: The immune microenvironment significantly influences neural regeneration in spinal cord injury (SCI). Lactate activates central nervous system (CNS) glial cells, prompting the secretion of proinflammatory cytokines and triggering an infla...

A Novel Diffusion Irradiation Method to Monitor Thermal Effects on Deep Subcutaneous Vessels Using Laser Speckle Contrast Imaging.

Journal of biophotonics
This study aims to investigate the effects of upper skin layers on laser light propagation and heat diffusion during laser surgery for vascular dermatosis. Using a rat dorsal window chamber model, deep-situated vessels are irradiated by a transcutane...

Activation of the Carotid Body by Kappa Opioid Receptors Mitigates Fentanyl-Induced Respiratory Depression.

Function (Oxford, England)
Previous studies reported that opioids depress breathing by inhibiting respiratory neural networks in the brainstem. The effects of opioids on sensory inputs regulating breathing are less studied. This study examined the effects of fentanyl and sufen...

Deep Eutectic Solvent Extraction Assisted Ligand Affinity Assay for α-Glucosidase Inhibitors Screening From the Plasma of Rats Administrated Pueraria lobata Extracts.

Journal of separation science
In this work, for the first time, a deep eutectic solvent assisted ligand affinity assay was proposed. Several critical parameters affecting the analysis performance were investigated and the optimized DES extract conditions were as follows: the solu...

Identification of key genes and immune infiltration mechanisms in limb ischemia-reperfusion injury: a bioinformatics and experimental study.

Frontiers in immunology
AIM OF THE STUDY: To establish a cross-tissue bioinformatics model for identifying conserved key genes and immune infiltration mechanisms in ischemia-reperfusion injury (IRI) with experimental validation in limb IRI, including pharmacological targeti...

Mechanism of Zuogui pill enhancing ovarian function and skin elastic repair in premature aging rats based on artificial intelligence medical image analysis.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
BACKGROUND: AI medical image analysis shows potential applications in research on premature aging and skin. The purpose of this study was to explore the mechanism of the Zuogui pill based on artificial intelligence medical image analysis on ovarian f...

Machine learning reveals ferroptosis features and a novel ferroptosis classifier in patients with sepsis.

Immunity, inflammation and disease
OBJECTIVE: Sepsis is an organ malfunction disease that may become fatal and is commonly accompanied by severe complications such as multiorgan dysfunction. Patients who are already hospitalized have a high risk of death due to sepsis. Even though ear...

Machine learning and deep learning to identifying subarachnoid haemorrhage macrophage-associated biomarkers by bulk and single-cell sequencing.

Journal of cellular and molecular medicine
We investigated subarachnoid haemorrhage (SAH) macrophage subpopulations and identified relevant key genes for improving diagnostic and therapeutic strategies. SAH rat models were established, and brain tissue samples underwent single-cell transcript...

[Experimental study of APB-DOCK8 transgenic tomato vaccine for caries prevention].

Shanghai kou qiang yi xue = Shanghai journal of stomatology
PURPOSE: To observe the anti-caries effect of transgenic tomato anti-caries vaccine after immunization with SD rats by gavage and to explore its immunity mechanism initially.

Antihypertensive Activity of Sauromatum guttatum Mediated by Vasorelaxation and Myocardial Depressant Effects.

Arquivos brasileiros de cardiologia
BACKGROUND: Sauromatum guttatum (S. guttatum) is used in the treatment of blood disorders and reportedly has a spasmolytic activity through Ca2+ channel inhibition.