AIMC Topic: Spectrophotometry, Ultraviolet

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Determination of terazosin in the presence of prazosin: Different state-of-the-art machine learning algorithms with UV spectroscopy.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Apr 8, 2020
Counterfeit drugs have adverse effects on public health; chromatographic methods can be used but they are costly. In this study, we developed cost-effective and environmentally friendly methodology for the analysis of terazosin HCl (TZ) in the presen...
Neural Networks, Computer Green Chemistry Technology Spectrophotometry, Ultraviolet Counterfeit Drugs Prazosin Machine Learning Algorithms Bayes Theorem Tablets
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Simultaneous ultra-trace quantitative colorimetric determination of antidiabetic drugs based on gold nanoparticles aggregation using multivariate calibration and neural network methods.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Mar 12, 2020
In this study, a simple and rapid method was investigated for the simultaneous ultra-trace colorimetric determination of Metformin (MET) and Sitagliptin (STG) based on the aggregation of gold nanoparticles (AuNPs). The Morphology and size distributio...
Analysis of Variance Spectrophotometry, Ultraviolet Sitagliptin Phosphate Least-Squares Analysis Metformin Calibration Neural Networks, Computer Colorimetry Multivariate Analysis Reproducibility of Results Hypoglycemic Agents Gold Metal Nanoparticles
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Orthogonal projection to latent structures and first derivative for manipulation of PLSR and SVR chemometric models' prediction: A case study.

PloS one Sep 25, 2019
Novel manipulations of the well-established multivariate calibration models namely; partial least square regression (PLSR) and support vector regression (SVR) are introduced in the presented comparative study. Two preprocessing methods comprising fir...
Support Vector Machine Drug Contamination Spectrophotometry, Ultraviolet Pyridostigmine Bromide Models, Statistical Least-Squares Analysis Models, Chemical Calibration
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Using artificial neural network and multivariate calibration methods for simultaneous spectrophotometric analysis of Emtricitabine and Tenofovir alafenamide fumarate in pharmaceutical formulation of HIV drug.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Feb 23, 2019
Spectrophotometric analysis method based on artificial neural network (ANN), partial least squares regression (PLS) and principal component regression (PCR) models was proposed for the simultaneous determination of Emtricitabine (ETB) and Tenofovir a...
Neural Networks, Computer Anti-HIV Agents Emtricitabine Adenine Least-Squares Analysis Calibration Alanine Tenofovir Multivariate Analysis Spectrophotometry, Ultraviolet
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Traceability of wild Paris polyphylla Smith var. yunnanensis based on data fusion strategy of FT-MIR and UV-Vis combined with SVM and random forest.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Jul 24, 2018
Paris polyphylla Smith var. yunnanensis (Franch.) Hand.-Mazz (PPY) was a frequently used herbal medicine in pharmaceutical field and different provenances might affect the clinical efficacy. Tracing the geographical origin was an important portion fo...
Decision Trees Spectrophotometry, Ultraviolet Melanthiaceae Plant Extracts Support Vector Machine Spectroscopy, Fourier Transform Infrared
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Use of ultraviolet-visible spectrophotometry associated with artificial neural networks as an alternative for determining the water quality index.

Environmental monitoring and assessment May 2, 2018
The water quality index (WQI) is an important tool for water resource management and planning. However, it has major disadvantages: the generation of chemical waste, is costly, and time-consuming. In order to overcome these drawbacks, we propose to s...
Environmental Monitoring Water Pollutants, Chemical Principal Component Analysis Ultraviolet Rays Water Quality Rivers Spectrophotometry, Ultraviolet Water Pollution, Chemical Neural Networks, Computer Brazil
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Chemical findings and in vitro biological studies to uphold the use of Ficus exasperata Vahl leaf and stem bark.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Dec 27, 2017
Ficus exasperata Vahl, commonly known as sandpaper, is a terrestrial Afro-tropical tree used in popular medicine. Despite the existence of some works on the biological activities of this species, its chemical composition is still poorly known. The ai...
Spectrophotometry, Ultraviolet Dietary Supplements Functional Food Plant Leaves Drug Screening Assays, Antitumor Free Radical Scavengers Humans Chromatography, High Pressure Liquid Plant Extracts Plant Bark Reproducibility of Results Superoxides Nitric Oxide Spectrometry, Mass, Electrospray Ionization Cell Line, Tumor Ficus Hypoglycemic Agents Plant Stems Dose-Response Relationship, Drug Inhibitory Concentration 50
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New insights into the efficiency of thymol synergistic effect with p-cymene in inhibiting advanced glycation end products: A multi-way analysis based on spectroscopic and electrochemical methods in combination with molecular docking study.

Journal of pharmaceutical and biomedical analysis Dec 24, 2017
Protein glycation in the body is one of the main reasons of diabetes complications. The electrochemical studies on the inhibitory mechanism of glycation are rather scarce. Thus, it is important to investigate the role of electrochemistry in the glyca...
Thymol Binding Sites Molecular Docking Simulation Serum Albumin, Bovine Protein Binding Glycation End Products, Advanced Spectrophotometry, Ultraviolet Arginine Cymenes Electrochemical Techniques Glycosylation Protein Conformation Kinetics Hypoglycemic Agents Lysine Drug Synergism Protein Processing, Post-Translational Monoterpenes Structure-Activity Relationship
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Stability of infliximab solutions in different temperature and dilution conditions.

Journal of pharmaceutical and biomedical analysis Dec 18, 2017
Infliximab is a monoclonal antibody widely used for the treatment of inflammatory diseases. Over the past few years, many studies have assessed that monoclonal antibodies are prone to aggregation under stress conditions. The aim of this study was to ...
Temperature Time Factors Nanoparticles Spectroscopy, Fourier Transform Infrared Infliximab Spectrophotometry, Ultraviolet Pharmaceutical Solutions Biosimilar Pharmaceuticals Chromatography, Gel Technology, Pharmaceutical Chromatography, Ion Exchange Antirheumatic Agents Nephelometry and Turbidimetry Peptide Mapping Protein Aggregates Protein Stability Drug Stability Drug Compounding Osmolar Concentration
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The application of artificial neural networks and support vector regression for simultaneous spectrophotometric determination of commercial eye drop contents.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Dec 5, 2017
In the present study, artificial neural networks (ANNs) and support vector regression (SVR) as intelligent methods coupled with UV spectroscopy for simultaneous quantitative determination of Dorzolamide (DOR) and Timolol (TIM) in eye drop. Several sy...
Ophthalmic Solutions Spectrophotometry, Ultraviolet Humans Sulfonamides Timolol Thiophenes Neural Networks, Computer Support Vector Machine
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