Synovial Membrane

Deciphering hub genes and immune landscapes related to neutrophil extracellular traps in rheumatoid arthritis: insights from integrated bioinformatics analyses and experiments.

Frontiers in immunology 39845946

BACKGROUND: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and progressive joint destruction. Neutrophil extracellular traps (NETs), a microreticular structure formed after neutrophil death, have rece...

Animals Arthritis, Rheumatoid Computational Biology Extracellular Traps Female Gene Expression Profiling Gene Regulatory Networks Humans Male Neutrophils Rats Synovial Membrane

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Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing.

Frontiers in immunology 39830504

BACKGROUND: Anti-citrullinated peptide antibodies (ACPA)-negative (ACPA-) rheumatoid arthritis (RA) presents significant diagnostic and therapeutic challenges due to the absence of specific biomarkers, underscoring the need to elucidate its distincti...

Adult Aged Anti-Citrullinated Protein Antibodies Arthritis, Rheumatoid Biomarkers Cellular Reprogramming Female Gene Regulatory Networks Humans Leukocytes, Mononuclear Macrophages Male Metabolic Reprogramming Middle Aged Sequence Analysis, RNA Single-Cell Analysis Synovial Membrane

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Mitochondrial dysfunction in rheumatoid arthritis: A comprehensive analysis by integrating gene expression, protein-protein interactions and gene ontology data.

PloS one 31703070

Several studies have reported mitochondrial dysfunction in rheumatoid arthritis (RA). Many nuclear DNA (nDNA) encoded proteins translocate to mitochondria, but their participation in the dysfunction of this cell organelle during RA is quite unclear. ...

Apoptosis Arthritis, Rheumatoid Gene Expression Profiling Gene Expression Regulation Gene Ontology Humans Inflammation Mitochondria Mitochondrial Proteins Models, Biological Oxidative Phosphorylation Protein Interaction Maps Reactive Oxygen Species Synovial Membrane

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Identification of Synovial Fibroblast-Associated Neuropeptide Genes and m6A Factors in Rheumatoid Arthritis Using Single-Cell Analysis and Machine Learning.

Disease markers 35186167

OBJECTIVES: Synovial fibroblasts (SFs) play an important role in the development and progression of rheumatoid arthritis (RA). However, the pathogenic mechanism of SFs remains unclear. The objective of this study was to investigate how neuropeptides ...

Adenosine Arthritis, Rheumatoid Fibroblasts Humans Machine Learning Neuropeptides Single-Cell Analysis Synovial Membrane

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Machine learning and weighted gene co-expression network analysis identify a three-gene signature to diagnose rheumatoid arthritis.

Frontiers in immunology 38711508

BACKGROUND: Rheumatoid arthritis (RA) is a systemic immune-related disease characterized by synovial inflammation and destruction of joint cartilage. The pathogenesis of RA remains unclear, and diagnostic markers with high sensitivity and specificity...

Arthritis, Rheumatoid Biomarkers Computational Biology Databases, Genetic Gene Expression Profiling Gene Regulatory Networks Humans Kinesins Machine Learning Ribonucleoside Diphosphate Reductase Support Vector Machine Synovial Membrane Transcriptome

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Artificial Intelligence Quantification of Enhanced Synovium Throughout the Entire Hand in Rheumatoid Arthritis on Dynamic Contrast-Enhanced MRI.

Journal of magnetic resonance imaging : JMRI 38807358

BACKGROUND: Challenges persist in achieving automatic and efficient inflammation quantification using dynamic contrast-enhanced (DCE) MRI in rheumatoid arthritis (RA) patients.

Adult Aged Arthritis, Rheumatoid Artificial Intelligence Contrast Media Female Hand Humans Image Interpretation, Computer-Assisted Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Retrospective Studies ROC Curve Synovial Membrane Synovitis

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Automated Deep Learning-Based Finger Joint Segmentation in 3-D Ultrasound Images With Limited Dataset.

Ultrasonic imaging 39295443

Ultrasound imaging has shown promise in assessing synovium inflammation associated early stages of rheumatoid arthritis (RA). The precise identification of the synovium and the quantification of inflammation-specific imaging biomarkers is a crucial a...

Arthritis, Rheumatoid Deep Learning Female Finger Joint Humans Imaging, Three-Dimensional Male Middle Aged Synovial Membrane Ultrasonography

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Identify the potential target of efferocytosis in knee osteoarthritis synovial tissue: a bioinformatics and machine learning-based study.

Frontiers in immunology 40083558

INTRODUCTION: Knee osteoarthritis (KOA) is a degenerative joint disease characterized by the progressive deterioration of cartilage and synovial inflammation. A critical mechanism in the pathogenesis of KOA is impaired efferocytosis in synovial tissu...

Computational Biology Databases, Genetic Efferocytosis Gene Expression Profiling Gene Regulatory Networks Humans Machine Learning Osteoarthritis, Knee Phagocytosis Synovial Membrane

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Machine learning analysis of FOSL2 and RHoBTB1 as central immunological regulators in knee osteoarthritis synovium.

The Journal of international medical research 40287984

BackgroundKnee osteoarthritis is a debilitating disease with a complex pathogenesis. Synovitis, which refers to inflammation of the synovial membrane surrounding the joint, is believed to play an important role in the development and progression of k...

Animals Disease Models, Animal Fos-Related Antigen-2 Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Humans Machine Learning Mice Osteoarthritis, Knee Synovial Membrane

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Molecular features and diagnostic modeling of synovium- and IPFP-derived OA macrophages in the inflammatory microenvironment via scRNA-seq and machine learning.

Journal of orthopaedic surgery and research 40247403

BACKGROUND: Osteoarthritis (OA) is the leading cause of degenerative joint disease, with total joint replacement as the only definitive cure. However, no disease-modifying therapy is currently available. Inflammation and fibrosis in the infrapatellar...

Adipose Tissue Animals Cellular Microenvironment Female Humans Inflammation Machine Learning Macrophages Male Middle Aged Osteoarthritis Rats Rats, Sprague-Dawley RNA-Seq Single-Cell Analysis Single-Cell Gene Expression Analysis Synovial Membrane

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Deciphering hub genes and immune landscapes related to neutrophil extracellular traps in rheumatoid arthritis: insights from integrated bioinformatics analyses and experiments.

Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing.

Mitochondrial dysfunction in rheumatoid arthritis: A comprehensive analysis by integrating gene expression, protein-protein interactions and gene ontology data.

Identification of Synovial Fibroblast-Associated Neuropeptide Genes and m6A Factors in Rheumatoid Arthritis Using Single-Cell Analysis and Machine Learning.

Machine learning and weighted gene co-expression network analysis identify a three-gene signature to diagnose rheumatoid arthritis.

Artificial Intelligence Quantification of Enhanced Synovium Throughout the Entire Hand in Rheumatoid Arthritis on Dynamic Contrast-Enhanced MRI.

Automated Deep Learning-Based Finger Joint Segmentation in 3-D Ultrasound Images With Limited Dataset.

Identify the potential target of efferocytosis in knee osteoarthritis synovial tissue: a bioinformatics and machine learning-based study.

Machine learning analysis of FOSL2 and RHoBTB1 as central immunological regulators in knee osteoarthritis synovium.

Molecular features and diagnostic modeling of synovium- and IPFP-derived OA macrophages in the inflammatory microenvironment via scRNA-seq and machine learning.

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