The Tumor-Stroma Ratio (TSR) is a critical prognostic factor in colorectal cancer (CRC), offering insights into tumor microenvironment interactions. However, traditional TSR assessment methods are subjective and labor-intensive. This study is among t...
Although it is the most common subtype of lung cancer in clinical practice, lung adenocarcinoma (LUAD) was proven to be associated with a poor prognosis. In recent years, lactate metabolism has been considered an important biological mechanism in lun...
Mitochondrial autophagy (mitophagy) in macrophages is crucial yet poorly understood within the lung adenocarcinoma (LUAD) tumor microenvironment. This study aimed to identify key macrophage mitophagy-related genes and develop a robust prognostic mode...
BACKGROUND: HPV status is a key determinant of prognosis and treatment response in head and neck squamous cell carcinoma (HNSCC). To investigate how HPV influences the tumor-immune-stromal landscape, we performed high-dimensional spatial profiling, i...
Accurate prognostication is essential to guide clinical management in localised cutaneous melanoma (CM), the form of skin cancer with the highest mortality. While the tumour microenvironment (TME) plays a key role in disease progression, current stag...
Cancer immunology, immunotherapy : CII
Nov 18, 2025
Immunohistochemistry (IHC) remains the gold standard for evaluating protein expression in tumor microenvironment analysis. This approach hinders robust correlation analyses between spatial heterogeneity in the tumor microenvironment and clinical outc...
Recent advances in spatial transcriptomics (ST) have significantly enhanced our understanding of tissue structure and intercellular interactions. However, existing methods for spatial domain identification and cell type deconvolution still face chall...
Therapeutic resistance remains a defining challenge in oncology, limiting the durability of current therapies and contributing to disease relapse and poor patient outcomes. This review systematically integrates recent progress in understanding the mo...
International journal of pharmaceutics
Nov 15, 2025
Oral cancer remains one of the most aggressive malignancies worldwide, with high recurrence and limited treatment outcomes due to late diagnosis and ineffective targeting of tumor microenvironments. Stem cell-based hydrogel therapies have emerged as ...
Protein therapeutics, particularly antibody-based therapies, have emerged as a cornerstone in modern disease treatment, offering key advantages over small molecules, including superior target specificity, longer half-life, and expanded target accessi...
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