AIMC Topic: Aged

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Efficacy, safety and pharmacokinetics of subcutaneous azacitidine in Chinese patients with higher risk myelodysplastic syndromes: Results from a multicenter, single-arm, open-label phase 2 study.

Asia-Pacific journal of clinical oncology
BACKGROUND: Azacitidine safety and efficacy were established in studies of mainly Caucasian patients. Differences in drug metabolism enzymes between Caucasian and East Asian populations prevent extrapolation of drug effects between these groups. This...

HCV nonstructural protein 4 is associated with aggressiveness features of breast cancer.

Breast cancer (Tokyo, Japan)
BACKGROUND: Hepatitis C virus (HCV) has the lymphotropic feature that is supposed to be the reason of related extrahepatic manifestation. HCV viral oncoproteins may participate in the regulation of some gene expression that has been implicated in tum...

Natural language processing of clinical notes for identification of critical limb ischemia.

International journal of medical informatics
BACKGROUND: Critical limb ischemia (CLI) is a complication of advanced peripheral artery disease (PAD) with diagnosis based on the presence of clinical signs and symptoms. However, automated identification of cases from electronic health records (EHR...

Regional arterial stiffness in central and peripheral arteries is differentially related to endothelial dysfunction assessed by brachial flow-mediated dilation in metabolic syndrome.

Diabetes & vascular disease research
The interrelationship between endothelial function and arterial stiffness may be different for central and peripheral arteries due to their structural and functional differences. The study aims to assess the interrelationship between central and peri...

Risk factors for predicting increased surgical drain output in patients after anterior cervical corpectomy and fusion.

Journal of orthopaedic surgery and research
BACKGROUND: Although measures to reduce and treat the postoperative surgical drain output are discussed, along with the increased interest in causative factors related to the prevention and treatment reported by many studies, these are still controve...

Convective radiofrequency water vapor thermal therapy for benign prostatic hyperplasia: a single office experience.

Prostate cancer and prostatic diseases
BACKGROUND: Convective radiofrequency water vapor thermal therapy with the Rezūm system is a relatively new treatment for benign prostatic hyperplasia (BPH). We present results from a single surgeon in an office setting.

Single-ended prediction of listening effort using deep neural networks.

Hearing research
The effort required to listen to and understand noisy speech is an important factor in the evaluation of noise reduction schemes. This paper introduces a model for Listening Effort prediction from Acoustic Parameters (LEAP). The model is based on met...

In Situ Skeletonized Right Internal Mammary Artery Bypass Grafting to Left Anterior Descending Artery.

International heart journal
This study aimed to evaluate the feasibility and the mid-term efficacy of an in situ skeletonized right internal mammary artery (IMA) bypass grafting to a left anterior descending artery (LAD), and to determine risk factors for IMA graft failure in a...