AIMC Topic: Antineoplastic Agents
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Synthesis of chitosan nanoparticles, chitosan-bulk, chitosan nanoparticles conjugated with glutaraldehyde with strong anti-cancer proliferative capabilities.
Artificial cells, nanomedicine, and biotechnology
Jan 31, 2019
In recent years, natural and synthetic polymers have attracted much attention due to their great potentials in medical science. In the present study, we have investigated the effect of chitosan-bulk (Ch-bulk), chitosan nanoparticles (ChNP), chitosan ...
Synthesis, characterization, antimicrobial and antimetastatic activity of silver nanoparticles synthesized from Ficus ingens leaf.
Artificial cells, nanomedicine, and biotechnology
Jan 28, 2019
Cancer incidence is still increasing due to inadequate responsive treatments. Inertness and biocompatibility of nanoparticles synthesized using plant extracts have shown therapeutic applications and make it to be a good anti-cancer candidates. This s...
Machine Learning Models for the Prediction of Chemotherapy-Induced Peripheral Neuropathy.
Pharmaceutical research
Jan 7, 2019
PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse side effect of cancer chemotherapy that can be life debilitating and cause extreme pain. The multifactorial and poorly understood mechanisms of toxicity have impeded the i...
Clinical intelligence: New machine learning techniques for predicting clinical drug response.
Computers in biology and medicine
Jan 3, 2019
Predicting the response, or sensitivity, of a clinical drug to a specific cancer type is an important research problem. By predicting the clinical drug response correctly, clinicians are able to understand patient-to-patient differences in drug sensi...
Design and synthesis of new phthalazine-based derivatives as potential EGFR inhibitors for the treatment of hepatocellular carcinoma.
Bioorganic chemistry
Dec 31, 2018
Searching for new leads in the battle of cancer will never ends, we herein disclose the design and synthesis of new phthalazine derivatives and their in vitro and in vivo testing for their antiproliferative activity. Phthalazine was selected as a pri...
Albumin binding, anticancer and antibacterial properties of synthesized zero valent iron nanoparticles.
International journal of nanomedicine
Dec 28, 2018
BACKGROUND: Nanoparticles (NPs) have been emerging as potential players in modern medicine with clinical applications ranging from therapeutic purposes to antimicrobial agents. However, before applications in medical agents, some in vitro studies sho...
Hypoxia-responsive micelles self-assembled from amphiphilic block copolymers for the controlled release of anticancer drugs.
Journal of materials chemistry. B
Dec 12, 2018
Amphiphilic block copolymers poly(ethylene glycol)-block-poly(methacrylic acid-co-2-nitroimidazole methacrylate) (PEG-b-P(MAA-co-NIMA)) were synthesized by the combination of atom transfer radical polymerization (ATRP), hydrolysis and EDC reactions. ...
Synthesis and characterization of Zinc oxide nanoparticles utilizing seed source of Ricinus communis and study of its antioxidant, antifungal and anticancer activity.
Materials science & engineering. C, Materials for biological applications
Dec 10, 2018
ZnO nanoparticles have been synthesized using solution combustion technique and its antioxidant, antifungal, anticancer activity was studied. Ricinus communis plant seed extract used as fuel in synthesis by the solution combustion technique. Powder X...
Plant Extracts
Spectroscopy, Fourier Transform Infrared
Seeds
Cell Survival
Antifungal Agents
Metal Nanoparticles
Zinc Oxide
Particle Size
Aspergillus
Antineoplastic Agents
Microbial Sensitivity Tests
Cell Line, Tumor
Antioxidants
Humans
Ricinus
X-Ray Diffraction
Green Chemistry Technology
Microscopy, Electron, Transmission
Penicillium
Dynamic changes in specific anti-L-asparaginase antibodies generation during acute lymphoblastic leukemia treatment.
Pharmacological reports : PR
Nov 28, 2018
BACKGROUND: L-asparaginase (L-asp) remains one of the key components of acute lymphoblastic leukemia therapy. Immune reactions to the drug are associated with its diminished activity. The aim of the study was to determine the level of IgM, IgG and Ig...
Predicting chemo-brain in breast cancer survivors using multiple MRI features and machine-learning.
Magnetic resonance in medicine
Nov 12, 2018
PURPOSE: Breast cancer (BC) is the most common cancer in women worldwide. There exist various advanced chemotherapy drugs for BC; however, chemotherapy drugs may result in brain damage during treatment. When a patient's brain is changed in response t...
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