AIMC Topic: Case-Control Studies
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Identifying ovarian cancer with machine learning DNA methylation pattern analysis.
Scientific reports
Jul 1, 2025
The majority of patients with epithelial ovarian cancer (EOC) continue to be diagnosed at an advanced stage despite great advances in this disease treatment. To impact overall survival, we need better methods of EOC early diagnosis. We performed a ca...
Different prefrontal cortex activity patterns in bipolar and unipolar depression during verbal fluency tasks based on functional near infrared spectroscopy study.
Scientific reports
Jul 1, 2025
This study aimed to investigate the functionality of the prefrontal cortex in patients with unipolar depression (UD) and bipolar depression (BD) using functional near-infrared spectroscopy (fNIRS) during a verbal fluency task (VFT). Additionally, it ...
Harnessing artificial intelligence for detection of pancreatic cancer: a machine learning approach.
Clinical and experimental medicine
Jul 1, 2025
PURPOSE: Pancreatic cancer (PC) is one of the most lethal malignancies, often presenting with nonspecific symptoms and a dismal prognosis. Despite advancements in treatments, the 5-year survival rate remains low, highlighting the urgent need for effe...
Breath profiles in paediatric allergic asthma by proton transfer reaction mass spectrometry.
BMJ open respiratory research
Jun 27, 2025
INTRODUCTION: Enhancing paediatric asthma diagnosis is crucial. Molecular analysis of exhaled breath is a rapidly evolving field aimed at harnessing established and innovative technologies for clinical applications. This study evaluates the feasibili...
The early prediction of neonatal necrotizing enterocolitis in high-risk newborns based on two medical center clinical databases.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Jun 23, 2025
: Early identification and timely preventive interventions play an essential role for improving the prognosis of newborns with necrotizing enterocolitis (NEC). Thus, establishing a novel and simple prediction model is of great clinical significance. ...
Predicting Early-Onset Colorectal Cancer in Individuals Below Screening Age Using Machine Learning and Real-World Data: Case Control Study.
JMIR cancer
Jun 19, 2025
BACKGROUND: Colorectal cancer is now the leading cause of cancer-related deaths among young Americans. Accurate early prediction and a thorough understanding of the risk factors for early-onset colorectal cancer (EOCRC) are vital for effective preven...
Case-control study combined with machine learning techniques to identify key genetic variations in GSK3B that affect susceptibility to diabetic kidney diseases.
BMC endocrine disorders
Jun 5, 2025
The role of genetic susceptibility in early warning and precise treatment of diabetic kidney disease (DKD) requires further investigation. A case-control study was conducted to evaluate the predictive effect of GSK3B genetic polymorphisms on the susc...
Detecting genetic interactions with visible neural networks.
Communications biology
Jun 5, 2025
Non-linear interactions among single nucleotide polymorphisms (SNPs), genes, and pathways play an important role in human diseases, but identifying these interactions is a challenging task. Neural networks are state-of-the-art predictors in many doma...
Machine learning for classification of pediatric bipolar disorder with and without psychotic symptoms based on thalamic subregional structural volume.
BMC psychiatry
Jun 3, 2025
BACKGROUND: The thalamus plays a crucial role in sensory processing, emotional regulation, and cognitive functions, and its dysregulation may be implicated in psychosis. The aim of the present study was to examine the differences in thalamic subregio...
Comparison of salivary statherin and beta-defensin-2 levels, oral health behaviors, and demographic factors in children with and without early childhood caries.
BMC oral health
May 31, 2025
BACKGROUND: Early childhood caries (ECC) is a widespread pediatric dental condition that is influenced by a combination of biological, behavioral, and demographic factors. Salivary biomarkers, including beta-defensin-2 (BD-2) and statherin (STATH), o...
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