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Cell-Free Nucleic Acids

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Clinical Significance of Circulating Cardiomyocyte-Specific Cell-Free DNA in Patients With Heart Failure: A Proof-of-Concept Study.

The Canadian journal of cardiology 32001048
We investigated clinical significance of cell-free DNA (cfDNA) in heart failure. This study enrolled 32 heart failure patients and 28 control subjects. Total cfDNA levels were not different between groups (P = 0.343). Bisulfite-digital polymerase cha...
Aged Biomarkers Cell Death Cell-Free Nucleic Acids Correlation of Data Echocardiography Female Heart Failure Humans Liquid Biopsy Male Myocytes, Cardiac Natriuretic Peptide, Brain Prognosis Stroke Volume Ventricular Dysfunction, Left Ventricular Remodeling
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The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer.

Genome medicine 29268796
BACKGROUND: Despite a myriad of attempts in the last three decades to diagnose ovarian cancer (OC) earlier, this clinical aim still remains a significant challenge. Aberrant methylation patterns of linked CpGs analyzed in DNA fragments shed by cancer...
Adult Aged Biomarkers, Tumor Cell-Free Nucleic Acids DNA Methylation Female Humans Middle Aged Ovarian Neoplasms Random Allocation Sequence Analysis, DNA
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Cell Free DNA and Procalcitonin as Early Markers of Complications in ICU Patients with Multiple Trauma and Major Surgery.

Clinical laboratory 28164563
BACKGROUND: Cell free DNA (cfDNA) was recently suggested as a new marker of sepsis and poor outcome in ICU patients. Procalcitonin has also been the focus of attention as an early marker for systemic inflammation and sepsis.
Adult Area Under Curve Biomarkers C-Reactive Protein Calcitonin Cell-Free Nucleic Acids DNA Early Diagnosis Female Hospital Mortality Humans Injury Severity Score Intensive Care Units Lactic Acid Length of Stay Male Middle Aged Multiple Trauma Organ Dysfunction Scores Postoperative Complications Predictive Value of Tests Prognosis Reproducibility of Results Risk Factors ROC Curve Sepsis Surgical Procedures, Operative Time Factors
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miRandola 2017: a curated knowledge base of non-invasive biomarkers.

Nucleic acids research 29036351
miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance of ncRNAs as non-invasive biomarkers. An increasing amount of experimental evidence shows ...
Biomarkers Cell-Free Nucleic Acids Data Curation Databases, Genetic Humans Knowledge Bases MicroRNAs RNA RNA, Circular RNA, Long Noncoding RNA, Untranslated User-Computer Interface
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Liver and Lung Transplant Advances.

JAMA 30860545
Cell-Free Nucleic Acids Delayed Graft Function End Stage Liver Disease Female Graft Rejection Humans Liver Transplantation Lung Diseases Lung Transplantation Machine Learning Male Prognosis Severity of Illness Index Waiting Lists
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Deep Learning/Artificial Intelligence and Blood-Based DNA Epigenomic Prediction of Cerebral Palsy.

International journal of molecular sciences 31035542
The etiology of cerebral palsy (CP) is complex and remains inadequately understood. Early detection of CP is an important clinical objective as this improves long term outcomes. We performed genome-wide DNA methylation analysis to identify epigenomic...
Artificial Intelligence Case-Control Studies Cell-Free Nucleic Acids Cerebral Palsy CpG Islands Deep Learning DNA Methylation Epigenesis, Genetic Epigenomics Gene Expression Profiling Gene Regulatory Networks Humans Infant, Newborn ROC Curve
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Circulating Neutrophil Extracellular Traps Signature for Identifying Organ Involvement and Response to Glucocorticoid in Adult-Onset Still's Disease: A Machine Learning Study.

Frontiers in immunology 33240258
Adult-onset Still's disease (AOSD) is an autoinflammatory disease with multisystem involvement. Early identification of patients with severe complications and those refractory to glucocorticoid is crucial to improve therapeutic strategy in AOSD. Exag...
Adult Case-Control Studies Cell-Free Nucleic Acids Cytokines Extracellular Traps Female Glucocorticoids Humans Male Middle Aged Prognosis Still's Disease, Adult-Onset Support Vector Machine Treatment Outcome Young Adult
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Utilization of circulating cell-free DNA profiling to guide first-line chemotherapy in advanced lung squamous cell carcinoma.

Theranostics 33391473
Platinum-based chemotherapy is one of treatment mainstay for patients with advanced lung squamous cell carcinoma (LUSC) but it is still a "one-size fits all" approach. Here, we aimed to investigate the predictive and monitoring role of circulating c...
Aged Antineoplastic Combined Chemotherapy Protocols Carcinoma, Squamous Cell Cell-Free Nucleic Acids Circulating Tumor DNA Cisplatin Deoxycytidine DNA Copy Number Variations Female Gemcitabine Humans Lung Neoplasms Machine Learning Male Middle Aged Paclitaxel Prognosis Progression-Free Survival Survival Rate Treatment Outcome
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DISMIR: Deep learning-based noninvasive cancer detection by integrating DNA sequence and methylation information of individual cell-free DNA reads.

Briefings in bioinformatics 34245239
Detecting cancer signals in cell-free DNA (cfDNA) high-throughput sequencing data is emerging as a novel noninvasive cancer detection method. Due to the high cost of sequencing, it is crucial to make robust and precise predictions with low-depth cfDN...
Cell-Free Nucleic Acids Computational Biology Deep Learning DNA Methylation DNA, Neoplasm Early Detection of Cancer High-Throughput Nucleotide Sequencing Humans Liquid Biopsy Neoplasm Staging Neoplasms Nucleotide Motifs Organ Specificity Sequence Analysis, DNA
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