AIMC Topic: Cell-Free Nucleic Acids
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Comprehensive tissue deconvolution of cell-free DNA by deep learning for disease diagnosis and monitoring.
Proceedings of the National Academy of Sciences of the United States of America
Jul 3, 2023
Plasma cell-free DNA (cfDNA) is a noninvasive biomarker for cell death of all organs. Deciphering the tissue origin of cfDNA can reveal abnormal cell death because of diseases, which has great clinical potential in disease detection and monitoring. D...
Prediction model for malignant pulmonary nodules based on cfMeDIP-seq and machine learning.
Cancer science
Jul 21, 2021
Cell-free methylated DNA immunoprecipitation and high-throughput sequencing (cfMeDIP-seq) is a new bisulfite-free technique, which can detect the whole-genome methylation of blood cell-free DNA (cfDNA). Using this technique, we identified differentia...
Utilization of circulating cell-free DNA profiling to guide first-line chemotherapy in advanced lung squamous cell carcinoma.
Theranostics
Jan 1, 2021
Platinum-based chemotherapy is one of treatment mainstay for patients with advanced lung squamous cell carcinoma (LUSC) but it is still a "one-size fits all" approach. Here, we aimed to investigate the predictive and monitoring role of circulating c...
Circulating Tumor DNA
Paclitaxel
Progression-Free Survival
Deoxycytidine
Gemcitabine
Treatment Outcome
Cell-Free Nucleic Acids
DNA Copy Number Variations
Cisplatin
Prognosis
Humans
Female
Machine Learning
Carcinoma, Squamous Cell
Middle Aged
Survival Rate
Aged
Lung Neoplasms
Male
Antineoplastic Combined Chemotherapy Protocols
Circulating Neutrophil Extracellular Traps Signature for Identifying Organ Involvement and Response to Glucocorticoid in Adult-Onset Still's Disease: A Machine Learning Study.
Frontiers in immunology
Nov 9, 2020
Adult-onset Still's disease (AOSD) is an autoinflammatory disease with multisystem involvement. Early identification of patients with severe complications and those refractory to glucocorticoid is crucial to improve therapeutic strategy in AOSD. Exag...
Clinical Significance of Circulating Cardiomyocyte-Specific Cell-Free DNA in Patients With Heart Failure: A Proof-of-Concept Study.
The Canadian journal of cardiology
Oct 19, 2019
We investigated clinical significance of cell-free DNA (cfDNA) in heart failure. This study enrolled 32 heart failure patients and 28 control subjects. Total cfDNA levels were not different between groups (P = 0.343). Bisulfite-digital polymerase cha...
Deep Learning/Artificial Intelligence and Blood-Based DNA Epigenomic Prediction of Cerebral Palsy.
International journal of molecular sciences
Apr 27, 2019
The etiology of cerebral palsy (CP) is complex and remains inadequately understood. Early detection of CP is an important clinical objective as this improves long term outcomes. We performed genome-wide DNA methylation analysis to identify epigenomic...
The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer.
Genome medicine
Dec 22, 2017
BACKGROUND: Despite a myriad of attempts in the last three decades to diagnose ovarian cancer (OC) earlier, this clinical aim still remains a significant challenge. Aberrant methylation patterns of linked CpGs analyzed in DNA fragments shed by cancer...
Detection of Brain Cancer Using Genome-wide Cell-free DNA Fragmentomes.
Cancer discovery
Aug 4, 2025
UNLABELLED: Diagnostic delays in patients with brain cancer are common and can impact patient outcome. Development of a blood-based assay for detection of brain cancers could accelerate brain cancer diagnosis. In this study, we analyzed genome-wide c...
Detection of Early-Stage Colorectal Cancer Using Cell-Free oncRNA Biomarkers and Artificial Intelligence.
Clinical cancer research : an official journal of the American Association for Cancer Research
Aug 1, 2025
PURPOSE: Colorectal cancer is the second leading cause of cancer-related deaths worldwide, and early detection significantly improves treatment outcomes, but existing blood-based tests often have limited sensitivity in early-stage disease. We develop...
Fetal growth disorders detection during first trimester gestation through comprehensive maternal circulating DNA profiling.
Human molecular genetics
Jun 18, 2025
BACKGROUND: Early diagnosis, close follow-up and timely delivery constitute the main elements for appropriate detection and management of Fetal Growth Disorders (FGD). We hypothesized that fetoplacental FGD-associated alterations can be detected in c...
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