AIMC Topic: Cell Survival
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Apoptosis of rat hepatic stellate cells induced by diallyl trisulfide and proteomics profiling in vitro.
Canadian journal of physiology and pharmacology
Nov 18, 2016
Diallyl trisulfide (DATS), a major garlic derivative, inhibits cell proliferation and triggers apoptosis in a variety of cancer cell lines. However, the effects of DATS on hepatic stellate cells (HSCs) remain unknown. The aim of this study was to ana...
Concurrent study of stability and cytotoxicity of a novel nanoemulsion system - an artificial neural networks approach.
Pharmaceutical development and technology
Oct 25, 2016
Problems commonly associated with using nanoemulsions are their cytotoxic effects and low stability profiles. Here, for the first time, concentrations of ingredients of a nanoemulsion system were investigated to obtain the most stable nanoemulsion sy...
PHYTOCHEMISTRY, CYTOTOXICITY AND APOPTOSIS STUDIES OF B-SITOSTEROL-3--GLUCOSIDE AND Β -AMYRIN FROM .
African journal of traditional, complementary, and alternative medicines : AJTCAM
Jul 3, 2016
BACKGROUND: is used traditionally in many countries for the treatment of cancer and benign prostate hyperplasia.
Nuquantus: Machine learning software for the characterization and quantification of cell nuclei in complex immunofluorescent tissue images.
Scientific reports
Mar 23, 2016
Determination of fundamental mechanisms of disease often hinges on histopathology visualization and quantitative image analysis. Currently, the analysis of multi-channel fluorescence tissue images is primarily achieved by manual measurements of tissu...
Antileishmanial activity of novel indolyl-coumarin hybrids: Design, synthesis, biological evaluation, molecular docking study and in silico ADME prediction.
Bioorganic & medicinal chemistry letters
Dec 24, 2015
In present work we have designed and synthesized total twelve novel 3-(3-(1H-indol-3-yl)-3-phenylpropanoyl)-4-hydroxy-2H-chromen-2-one derivatives 13(a-l) using Ho(3+) doped CoFe2O4 nanoparticles as catalyst and evaluated for their potential antileis...
Preparation of Concentrated Chitosan/DNA Nanoparticle Formulations by Lyophilization for Gene Delivery at Clinically Relevant Dosages.
Journal of pharmaceutical sciences
Dec 23, 2015
Chitosan/DNA polyplexes have been optimized for efficient and safe in vitro and in vivo gene delivery. Clinical application of this technology requires the development of formulations with higher concentrations to reach therapeutic dosages. Polyplexe...
Preparation, Characterization, and Antitumor Activities of Miriplatin-Loaded Liposomes.
Journal of pharmaceutical sciences
Dec 22, 2015
Because of the insolubility of miriplatin in water, miriplatin and lipiodol suspension is the sole formulation of miriplatin approved in Japan to treat hepatocellular carcinoma by transcatheter arterial chemoembolization. Until now, there have been n...
Preparation, characterization and biocompatibility studies of thermoresponsive eyedrops based on the combination of nanostructured lipid carriers (NLC) and the polymer Pluronic F-127 for controlled delivery of ibuprofen.
Pharmaceutical development and technology
Dec 20, 2015
CONTEXT: Nanostructured lipid carrier (NLC) dispersions present low viscosity and poor mucoadhesive properties, which reduce the pre-corneal residence time and consequently, the bioavailability of ocular drugs.
The Effect of Leonurus sibiricus Plant Extracts on Stimulating Repair and Protective Activity against Oxidative DNA Damage in CHO Cells and Content of Phenolic Compounds.
Oxidative medicine and cellular longevity
Dec 14, 2015
Leonurus sibiricus L. has been used as a traditional and medicinal herb for many years in Asia and Europe. This species is known to have antibacterial, anti-inflammatory, and antioxidant activity and has demonstrated a reduction of intracellular reac...
Leonurus
DNA Damage
Chromatography, High Pressure Liquid
Regeneration
Spectrometry, Mass, Electrospray Ionization
Gene Expression Regulation
Cytoprotection
Cricetinae
DNA Breaks, Double-Stranded
DNA Repair
Protective Agents
Phenols
CHO Cells
Cricetulus
Animals
Oxidation-Reduction
Antioxidants
Plant Extracts
Wound Healing
Cell Survival
Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification.
Methods (San Diego, Calif.)
Dec 11, 2015
Biologists increasingly use co-culture systems in which two or more cell types are grown in cell culture together in order to better model cells' native microenvironments. Co-cultures are often required for cell survival or proliferation, or to maint...
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