AIMC Topic: Choline

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Comprehensive Evaluation of Human and Murine Protein Coronae Formed on Choline Carboxylic Acid Ionic Liquid-Modified PLGA Nanoparticles.

Bioconjugate chemistry Dec 8, 2025
Despite decades of research, the successful clinical translation of intravenously administered nanomedicines is underwhelming. One significant barrier to progress is the opsonization and rapid clearance from the bloodstream due to protein corona form...
Choline Humans Ionic Liquids Animals Carboxylic Acids Mice Protein Corona Nanoparticles Polylactic Acid-Polyglycolic Acid Copolymer
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A flexible, stretchable and wearable strain sensor based on physical eutectogels for deep learning-assisted motion identification.

Journal of materials chemistry. B Jun 27, 2024
Physical eutectogels as a newly emerging type of conductive gel have gained extensive interest for the next generation multifunctional electronic devices. Nevertheless, some obstacles, including weak mechanical performance, low self-adhesive strength...
Choline Gels Acrylates Electric Conductivity Deep Eutectic Solvents Humans Deep Learning Wearable Electronic Devices Particle Size Lignin
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Frequency and phase correction of GABA-edited magnetic resonance spectroscopy using complex-valued convolutional neural networks.

Magnetic resonance imaging May 12, 2024
PURPOSE: To determine the significance of complex-valued inputs and complex-valued convolutions compared to real-valued inputs and real-valued convolutions in convolutional neural networks (CNNs) for frequency and phase correction (FPC) of GABA-edite...
Brain Computer Simulation Deep Learning Choline Humans Neural Networks, Computer Algorithms Artifacts Signal-To-Noise Ratio Magnetic Resonance Spectroscopy gamma-Aminobutyric Acid
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Breast PET/MRI Hybrid Imaging and Targeted Tracers.

Journal of magnetic resonance imaging : JMRI Sep 27, 2022
The recent introduction of hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) as a promising imaging modality for breast cancer assessment has prompted fervent research activity on its clinical applications. The current knowledg...
Humans Artificial Intelligence Female Breast Neoplasms Magnetic Resonance Imaging Fluorodeoxyglucose F18 Magnetic Resonance Spectroscopy Multimodal Imaging Radiopharmaceuticals Positron-Emission Tomography Choline
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Solvent Screening for Solubility Enhancement of Theophylline in Neat, Binary and Ternary NADES Solvents: New Measurements and Ensemble Machine Learning.

International journal of molecular sciences Jul 8, 2021
Theophylline, a typical representative of active pharmaceutical ingredients, was selected to study the characteristics of experimental and theoretical solubility measured at 25 °C in a broad range of solvents, including neat, binary mixtures and tern...
Machine Learning Water Models, Chemical Solubility Choline Solvents Theophylline
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Artificial intelligence-based versus manual assessment of prostate cancer in the prostate gland: a method comparison study.

Clinical physiology and functional imaging Sep 8, 2019
AIM: To test the feasibility of a fully automated artificial intelligence-based method providing PET measures of prostate cancer (PCa).
Fluorine Radioisotopes Prostatectomy Radiopharmaceuticals Choline Image Interpretation, Computer-Assisted Automation Aged Male Middle Aged Predictive Value of Tests Positron Emission Tomography Computed Tomography Prostatic Neoplasms Prostate Workflow Feasibility Studies Humans Neural Networks, Computer
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Incorporation of a spectral model in a convolutional neural network for accelerated spectral fitting.

Magnetic resonance in medicine Jan 21, 2019
PURPOSE: MRSI has shown great promise in the detection and monitoring of neurologic pathologies such as tumor. A necessary component of data processing includes the quantitation of each metabolite, typically done through fitting a model of the spectr...
Computer Graphics Creatine Echo-Planar Imaging Signal-To-Noise Ratio Brain Neoplasms White Matter Models, Theoretical Deep Learning Magnetic Resonance Spectroscopy Humans Brain Mapping Aspartic Acid Neural Networks, Computer User-Computer Interface Glioblastoma Software Image Processing, Computer-Assisted Choline Algorithms Artifacts Databases, Factual
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F-Choline Positron Emission Tomography/Computed Tomography and Multiparametric Magnetic Resonance Imaging for the Detection of Early Local Recurrence of Prostate Cancer Initially Treated by Radiation Therapy: Comparison With Systematic 3-Dimensional Transperineal Mapping Biopsy.

International journal of radiation oncology, biology, physics Dec 28, 2016
PURPOSE: To compare the diagnostic performance of F-fluorocholine positron emission tomography/computed tomography (FCH-PET/CT), multiparametric prostate magnetic resonance imaging (mpMRI), and a combination of both techniques for the detection of lo...
Magnetic Resonance Imaging Positron Emission Tomography Computed Tomography Sensitivity and Specificity Prostatic Neoplasms Neoplasm Recurrence, Local Biopsy Humans Male Radiopharmaceuticals Retrospective Studies Middle Aged Choline Reproducibility of Results Imaging, Three-Dimensional Aged
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Patterns of Recurrence After Postprostatectomy Fossa Radiation Therapy Identified by C-11 Choline Positron Emission Tomography/Computed Tomography.

International journal of radiation oncology, biology, physics Nov 17, 2016
PURPOSE: To evaluate C-11 choline positron emission tomography/computed tomography (CholPET) in staging and determining patterns of recurrence in prostate cancer patients with rising prostate-specific antigen levels after prostatectomy radiation ther...
Postoperative Care Positron Emission Tomography Computed Tomography Prostatic Neoplasms Prostate-Specific Antigen Neoplasm Grading Viscera Neoplasm Recurrence, Local Humans Male Carbon Radioisotopes Middle Aged Choline Aged Lymphatic Metastasis Prostatectomy Bone Neoplasms Statistics, Nonparametric
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Adaptations to excess choline in insulin resistant and Pcyt2 deficient skeletal muscle.

Biochemistry and cell biology = Biochimie et biologie cellulaire Sep 6, 2016
It was hypothesized that choline supplementation in insulin resistant (IR) CTP:phosphoethanolamine cytidylyltransferase deficient (Pcyt2) mice would ameliorate muscle function by remodeling glucose and fatty acid (FA) metabolism. Pcyt2 mice either re...
Triglycerides Microtubule-Associated Proteins Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Stearoyl-CoA Desaturase Lipogenesis Adaptation, Physiological Carnitine O-Palmitoyltransferase Diacylglycerol O-Acyltransferase Insulin Receptor Substrate Proteins Fatty Acids Administration, Oral Choline Gene Expression Regulation PPAR alpha Signal Transduction Organic Cation Transport Proteins Animals Muscle, Skeletal RNA Nucleotidyltransferases Mice Mice, Knockout Sterol Regulatory Element Binding Protein 1 fas Receptor Insulin Resistance Glucose
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