AIMC Topic: Cohort Studies

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Early detection of Alzheimer's disease using small RNAs. Results from the EPAD cohort.

The journal of prevention of Alzheimer's disease
BACKGROUND: Alzheimer's disease (AD) is the most common form of dementia, and early diagnosis is crucial to enable effective interventions. Currently, Alzheimer's disease is diagnosed through cognitive assessments, brain imaging and fluid biomarkers ...

Machine learning for the prediction of spontaneous preterm birth using early second and third trimester maternal blood gene expression: A cautionary tale.

PloS one
Spontaneous preterm birth (sPTB) remains a significant global health challenge and a leading cause of neonatal mortality and morbidity. Despite advancements in neonatal care, the prediction of sPTB remains elusive, in part due to complex etiologies a...

Development of Machine Learning-Based Risk Prediction Models to Predict Rapid Weight Gain in Infants: Analysis of Seven Cohorts.

JMIR public health and surveillance
BACKGROUND: Rapid weight gain (RWG) during infancy, defined as an upward crossing of one centile line on a weight growth chart, is highly predictive of subsequent obesity risk. Identification of infant RWG could facilitate obesity risk assessment fro...

Exploratory multi-cohort, multi-reader study on the clinical utility of a deep learning model for transforming cryosectioned to formalin-fixed, paraffin-embedded (FFPE) images in breast lesion diagnosis.

Breast cancer research : BCR
BACKGROUND: Cryosectioned tissues often exhibit artifacts that compromise pathologists' diagnostic accuracy during intraoperative assessments. These inconsistencies, compounded by variations in frozen section (FS) production across laboratories, high...

Patterns of calcitonin gene-related peptide monoclonal antibody use in people with migraine: Results of the OVERCOME (US) study.

Cephalalgia : an international journal of headache
BackgroundUnderstanding characteristics and reasons associated with using calcitonin gene-related peptide monoclonal antibodies (CGRP mAb) for migraine prevention may help clinicians individualize treatment plans and achieve better patient outcomes.M...

Air Pollution and Autism Spectrum Disorder: Unveiling Multipollutant Risks and Sociodemographic Influences in California.

Environmental health perspectives
BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition with increasing prevalence worldwide. Air pollution may be a major contributor to the rise in ASD cases. This study investigated how the risk of ASD associated with prenatal...

Identifying patients at risk of increased health utilization following lumbar spine surgery.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
BACKGROUND: Adequate preoperative identification of patients at risk of significant healthcare utilization after surgery could help guide preoperative decision-making as well as postoperative patient management. While several studies have proposed me...

Comparison of Multimodal Deep Learning Approaches for Predicting Clinical Deterioration in Ward Patients: Observational Cohort Study.

Journal of medical Internet research
BACKGROUND: Implementing machine learning models to identify clinical deterioration in the wards is associated with decreased morbidity and mortality. However, these models have high false positive rates and only use structured data.