AIMC Topic: Cyclopropanes

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EC and EC of Remifentanil for Inhibiting Bronchoscopy Responses in Elderly Patients During Fiberoptic Bronchoscopy Under Ciprofol Sedation: An Up-and-Down Sequential Allocation Trial.

Drug design, development and therapy Dec 31, 2024
BACKGROUND: Opioids are used to suppress cough during fiberoptic bronchoscopy (FOB). However, evidence regarding the optimal dose of remifentanil during FOB under ciprofol sedation is limited. This study aimed to investigate the effective concentrati...
Cyclopropanes Middle Aged Remifentanil Bronchoscopy Humans Dose-Response Relationship, Drug Female Fiber Optic Technology Aged Hypnotics and Sedatives Aged, 80 and over Male
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Optimizing removal of antiretroviral drugs from tertiary wastewater using chlorination and AI-based prediction with response surface methodology.

The Science of the total environment May 3, 2024
Chemical and pharmaceutical chemicals found in water sources create substantial risks to human health and the environment. The presence of pharmaceutical contaminants in water can cause antibiotic resistance development, toxicity to aquatic organisms...
Cyclopropanes Anti-Retroviral Agents Alkynes Benzoxazines Halogenation Nevirapine Neural Networks, Computer Wastewater Waste Disposal, Fluid Water Pollutants, Chemical
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Artificial intelligence-driven drug repositioning uncovers efavirenz as a modulator of α-synuclein propagation: Implications in Parkinson's disease.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Mar 20, 2024
Parkinson's disease (PD) is a complex neurodegenerative disorder with an unclear etiology. Despite significant research efforts, developing disease-modifying treatments for PD remains a major unmet medical need. Notably, drug repositioning is becomin...
Parkinson Disease Drug Repositioning alpha-Synuclein Mice, Transgenic Caenorhabditis elegans Humans Alkynes Benzoxazines Artificial Intelligence Nevirapine Animals Mice Disease Models, Animal Mice, Inbred C57BL Cyclopropanes
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The effectiveness of gabapentin and gabapentin/montelukast combination compared with dextromethorphan in the improvement of COVID-19- related cough: A randomized, controlled clinical trial.

The clinical respiratory journal Jul 31, 2022
INTRODUCTION: Cough is one of the most common presenting symptoms of COVID-19, which can persist for weeks or months.
Humans COVID-19 SARS-CoV-2 Treatment Outcome Gabapentin Dextromethorphan Cyclopropanes Cough Acetates Sulfides COVID-19 Drug Treatment Quinolines
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MDL-CPI: Multi-view deep learning model for compound-protein interaction prediction.

Methods (San Diego, Calif.) Jan 31, 2022
Elucidating the mechanisms of Compound-Protein Interactions (CPIs) plays an essential role in drug discovery and development. Many computational efforts have been done to accelerate the development of this field. However, the current predictive perfo...
Neural Networks, Computer Software Deep Learning Cyclopropanes Proteins Indoles
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Deep-learning based repurposing of FDA-approved drugs against dihydrofolate reductase and molecular dynamics study.

Journal of biomolecular structure & dynamics Apr 21, 2021
causes the fatal fungal bloodstream infection in humans called Candidiasis. Most of the species are resistant to the antifungals used to treat them. Drug-resistant poses very serious public health issues. To overcome this, the development of effec...
Rifampin Folic Acid Antagonists Aminopyridines Tetrahydrofolate Dehydrogenase Molecular Dynamics Simulation Benzodioxoles Sulfonamides United States Food and Drug Administration Proline Lactams, Macrocyclic Drug Approval Candida albicans Cyclopropanes Drug Repositioning Candidiasis Antifungal Agents Humans Molecular Docking Simulation Deep Learning United States
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Ritonavir-boosted paritaprevir, ombitasvir plus ribavirin could improve eGFR in patients with renal impairment and HCV: an Egyptian cohort.

Expert review of gastroenterology & hepatology Nov 13, 2018
BACKGROUND: The present study aimed at evaluation of changes in estimated glomerular filtration rate (eGFR) among chronic Hepatitis C virus (HCV) patients with chronic kidney disease (CKD) Stages 3-5 who were treated with 12 weeks of ritonavir-booste...
Glomerular Filtration Rate Cyclopropanes Recovery of Function Egypt Sulfonamides Hepacivirus Antiviral Agents Genotype Kidney Renal Insufficiency, Chronic Treatment Outcome Lactams, Macrocyclic Macrocyclic Compounds Ribavirin Sustained Virologic Response Humans Proline Adult Prospective Studies Drug Therapy, Combination Male Female Hepatitis C, Chronic Middle Aged Valine Aged Renal Dialysis Anilides Young Adult Viral Load Carbamates Time Factors
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Efficacy and safety of lebrikizumab in adult patients with mild-to-moderate asthma not receiving inhaled corticosteroids.

Respiratory medicine Dec 13, 2017
BACKGROUND: Asthma is a heterogeneous and complex disease in both its clinical course and response to treatment. IL-13 is central to Type 2 inflammation and contributes to many features of asthma. In a previous Phase 2 study, lebrikizumab, an anti-IL...
Forced Expiratory Volume Acetates Sulfides Treatment Failure Quinolines Administration, Inhalation Anti-Asthmatic Agents Severity of Illness Index Injections, Subcutaneous Treatment Outcome Cyclopropanes Antibodies, Monoclonal Double-Blind Method Adult Asthma Male Middle Aged Glucocorticoids Humans Female
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin for chronic hepatitis C virus genotype 4 infection in Egyptian patients with or without compensated cirrhosis (AGATE-II): a multicentre, phase 3, partly randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: In Egypt, chronic hepatitis C virus (HCV) infection occurs in around 10% of the population (about 8 million individuals), and is a leading cause of liver cirrhosis, hepatocellular carcinoma, and mortality. Although HCV genotype 4 constitu...
Humans Female Aged Aged, 80 and over Young Adult Hepacivirus Administration, Oral Proline Ritonavir Drug Therapy, Combination Hepatitis C, Chronic Valine Drug Administration Schedule Anilides Carbamates Lactams, Macrocyclic Macrocyclic Compounds Liver Cirrhosis Treatment Outcome Follow-Up Studies Cyclopropanes Egypt Sulfonamides Adult Male Middle Aged Adolescent Antiviral Agents Genotype Ribavirin Sustained Virologic Response
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin in adults with hepatitis C virus genotype 4 infection and cirrhosis (AGATE-I): a multicentre, phase 3, randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: Hepatitis C virus (HCV) genotype 4 infection is most commonly reported in sub-Saharan Africa and the Middle East; however, prevalence is increasing worldwide through immigration. HCV genotype 4 accounts for 20% of all infections, but clin...
Ribavirin Sustained Virologic Response Drug Administration Schedule Anilides Carbamates Lactams, Macrocyclic Macrocyclic Compounds Aged, 80 and over Humans Young Adult Female Adult Aged Male Middle Aged Adolescent Hepacivirus Proline Ritonavir Drug Therapy, Combination Hepatitis C, Chronic Valine Antiviral Agents Genotype Treatment Outcome Follow-Up Studies Cyclopropanes Sulfonamides
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