AIMC Topic: Diabetic Nephropathies

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A validated multivariable machine learning model to predict cardio-kidney risk in diabetic kidney disease.

Cardiovascular diabetology May 15, 2025
BACKGROUND: Individuals with diabetic kidney disease (DKD) often suffer cardiac and kidney events. We sought to develop an accurate means by which to stratify risk in DKD.
Humans Machine Learning Heart Diseases Male Heart Disease Risk Factors Cardiovascular Diseases Middle Aged Diabetic Nephropathies Predictive Value of Tests Sodium-Glucose Transporter 2 Inhibitors Risk Assessment Time Factors Female Decision Support Techniques Risk Factors Reproducibility of Results Biomarkers Aged Prognosis
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Integrating bioinformatics and machine learning to identify glomerular injury genes and predict drug targets in diabetic nephropathy.

Scientific reports May 15, 2025
Diabetes mellitus (DM) is a chronic metabolic disorder that poses significant challenges to public health. Among its various complications, diabetic nephropathy (DN) emerges as a critical microvascular complication associated with high mortality rate...
Humans Machine Learning Animals Gene Expression Profiling Computational Biology Kidney Glomerulus Gene Regulatory Networks Databases, Genetic Mice Gene Ontology Diabetic Nephropathies
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Deep learning algorithms to detect diabetic kidney disease from retinal photographs in multiethnic populations with diabetes.

Journal of the American Medical Informatics Association : JAMIA Nov 17, 2023
OBJECTIVE: To develop a deep learning algorithm (DLA) to detect diabetic kideny disease (DKD) from retinal photographs of patients with diabetes, and evaluate performance in multiethnic populations.
Humans Diabetic Retinopathy Algorithms Cross-Sectional Studies Longitudinal Studies Australia Deep Learning Diabetes Mellitus, Type 2 Diabetic Nephropathies
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Deep learning-based multi-omics study reveals the polymolecular phenotypic of diabetic kidney disease.

Clinical and translational medicine Jun 1, 2023
Diabetic Nephropathies Multiomics Diabetes Mellitus Humans Deep Learning
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Research digest: progress in microvascular complications.

The lancet. Diabetes & endocrinology Feb 1, 2018
Prevalence Severity of Illness Index Diabetes Mellitus, Type 2 Diabetic Nephropathies Diabetic Angiopathies Machine Learning Risk Factors Disease Progression Humans Diabetic Retinopathy
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Pattern and predictors of urine protein excretion among patients with type 2 diabetes attending a single tertiary hospital in Lagos, Nigeria.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia Jan 1, 2017
Testing for proteinuria is used to screen for diabetic nephropathy. However, significant proportion of diabetics has normal urine protein excretion despite impaired renal function. We aimed to determine the factors predicting increased urine protein ...
Hypertension Angiotensin-Converting Enzyme Inhibitors Tertiary Care Centers Glomerular Filtration Rate Diabetes Mellitus, Type 2 Blood Pressure Risk Assessment Creatinine Female Aged, 80 and over Antihypertensive Agents Nigeria Risk Factors Adult Male Aged Cross-Sectional Studies Middle Aged Humans Biomarkers Prognosis Angiotensin II Type 1 Receptor Blockers Proteinuria Diabetic Nephropathies Kidney
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Lactate levels and risk of lactic acidosis with metformin in diabetic kidney disease patients.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia Jan 1, 2017
Metformin as an oral antidiabetic drug (OAD) is not recommended in renal failure due to the presumed risk of lactic acidosis though it has advantages in cardiovascular protection with a low risk of hypoglycemia. Few studies have measured lactic acid ...
Diabetic Nephropathies Hypoglycemic Agents Renal Insufficiency, Chronic Administration, Oral Metformin Treatment Outcome Hydrogen-Ion Concentration Middle Aged Risk Assessment Case-Control Studies Diabetes Mellitus, Type 2 Humans Female Biomarkers Risk Factors Lactic Acid Male Bicarbonates Acidosis, Lactic
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Neutrophil Gelatinase-Associated Lipocalin as an Early Sign of Diabetic Kidney Injury in Children.

Journal of clinical research in pediatric endocrinology Dec 1, 2015
OBJECTIVE: There is some evidence indicating that histopathological changes in type 1 diabetes mellitus (T1DM) emerge before onset of microalbuminuria. The aim of our study was to determine whether urine neutrophil gelatinase-associated lipocalin (NG...
Proto-Oncogene Proteins Child Lipocalin-2 Diabetic Nephropathies Humans Lipocalins Male Diabetes Mellitus, Type 1 Female Adolescent Acute-Phase Proteins Albuminuria
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