AIMC Topic: Disease Models, Animal

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Deep Learning to Decipher the Progression and Morphology of Axonal Degeneration.

Cells Sep 25, 2021
Axonal degeneration (AxD) is a pathological hallmark of many neurodegenerative diseases. Deciphering the morphological patterns of AxD will help to understand the underlying mechanisms and develop effective therapies. Here, we evaluated the progressi...
Animals Deep Learning Disease Models, Animal Neurodegenerative Diseases Neurons Cell Death Axons Humans Nerve Degeneration
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Peak learning of mass spectrometry imaging data using artificial neural networks.

Nature communications Sep 20, 2021
Mass spectrometry imaging (MSI) is an emerging technology that holds potential for improving, biomarker discovery, metabolomics research, pharmaceutical applications and clinical diagnosis. Despite many solutions being developed, the large data size ...
Animals Neoplasms Deep Learning Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Imaging, Three-Dimensional Humans Nonlinear Dynamics Mice Neural Networks, Computer Connective Tissue Kidney alpha-Defensins Algorithms Disease Models, Animal Reproducibility of Results Metabolomics
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Vesseg: An Open-Source Tool for Deep Learning-Based Atherosclerotic Plaque Quantification in Histopathology Images-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology Aug 12, 2021
Objective: Manual plaque segmentation in microscopy images is a time-consuming process in atherosclerosis research and potentially subject to unacceptable user-to-user variability and observer bias. We address this by releasing Vesseg a tool that inc...
Predictive Value of Tests Atherosclerosis Microscopy Image Interpretation, Computer-Assisted Mice Staining and Labeling Disease Models, Animal Mice, Inbred C57BL Vascular Remodeling Mice, Knockout, ApoE Plaque, Atherosclerotic Arteries Software Female Reproducibility of Results Animals Male Severity of Illness Index Diagnosis, Computer-Assisted Deep Learning
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Skilled reach training enhances robotic gait training to restore overground locomotion following spinal cord injury in rats.

Behavioural brain research Aug 3, 2021
Rehabilitative training has been shown to improve motor function following spinal cord injury (SCI). Unfortunately, these gains are primarily task specific; where reach training only improves reaching, step training only improves stepping and stand t...
Humans Animals Rats Disease Models, Animal Motor Activity Gait Disorders, Neurologic Neurological Rehabilitation Robotics Behavior, Animal Spinal Cord Injuries Diffusion Tensor Imaging
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Artificial intelligence-driven phenotyping of zebrafish psychoactive drug responses.

Progress in neuro-psychopharmacology & biological psychiatry Jul 25, 2021
Zebrafish (Danio rerio) are rapidly emerging in biomedicine as promising tools for disease modelling and drug discovery. The use of zebrafish for neuroscience research is also growing rapidly, necessitating novel reliable and unbiased methods of neur...
Neural Networks, Computer Artificial Intelligence Algorithms Animals Drug Discovery Drug Development Disease Models, Animal Zebrafish Datasets as Topic Locomotion Psychotropic Drugs
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Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease.

Nature communications Jul 12, 2021
Modeling human diseases as networks simplify complex multi-cellular processes, helps understand patterns in noisy data that humans cannot find, and thereby improves precision in prediction. Using Inflammatory Bowel Disease (IBD) as an example, here w...
Likelihood Functions Dextran Sulfate Colitis Organoids AMP-Activated Protein Kinases Animals Multigene Family Cohort Studies Gene Expression Regulation Mice Molecular Targeted Therapy Artificial Intelligence Disease Models, Animal Treatment Outcome Machine Learning Humans Mice, Inbred C57BL Inflammatory Bowel Diseases Intestinal Mucosa Reproducibility of Results Mice, Knockout
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Hemopneumothorax detection through the process of artificial evolution - a feasibility study.

Military Medical Research Apr 25, 2021
BACKGROUND: Tension pneumothorax is one of the leading causes of preventable death on the battlefield. Current prehospital diagnosis relies on a subjective clinical impression complemented by a manual thoracic and respiratory examination. These techn...
Artificial Intelligence Animals Swine Hemopneumothorax Disease Models, Animal Feasibility Studies Stethoscopes Auscultation
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Neurovascular multiparametric MRI defines epileptogenic and seizure propagation regions in experimental mesiotemporal lobe epilepsy.

Epilepsia Apr 5, 2021
OBJECTIVE: Improving the identification of the epileptogenic zone and associated seizure-spreading regions represents a significant challenge. Innovative brain-imaging modalities tracking neurovascular dynamics during seizures may provide new disease...
Brain Mapping Hippocampus Epilepsy, Temporal Lobe Multiparametric Magnetic Resonance Imaging Image Processing, Computer-Assisted Mice Disease Models, Animal Mice, Inbred C57BL Machine Learning Animals Male
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Prediction of cerebral perfusion pressure during CPR using electroencephalogram in a swine model of ventricular fibrillation.

The American journal of emergency medicine Feb 25, 2021
BACKGROUND: Measuring the quality of cardiopulmonary resuscitation (CPR) is important for improving outcomes in cardiac arrest. Cerebral perfusion pressure (CePP) could represent cerebral circulation during CPR, but it is difficult to measure non-inv...
Cerebrovascular Circulation Swine Machine Learning Cardiopulmonary Resuscitation Disease Models, Animal Female Ventricular Fibrillation Electroencephalography Animals Cross-Over Studies
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Proof of Concept for a Deep Learning Algorithm for Identification and Quantification of Key Microscopic Features in the Murine Model of DSS-Induced Colitis.

Toxicologic pathology Feb 12, 2021
Inflammatory bowel disease (IBD) is a complex disease which leads to life-threatening complications and decreased quality of life. The dextran sulfate sodium (DSS) colitis model in mice is known for rapid screening of candidate compounds. Efficacy as...
Colitis Mice Disease Models, Animal Mice, Inbred C57BL Dextran Sulfate Artificial Intelligence Animals Colon Quality of Life Deep Learning
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