Disease Models, Animal

Deep learning enables pathologist-like scoring of NASH models.

Scientific reports Dec 5, 2019

Non-alcoholic fatty liver disease (NAFLD) and the progressive form of non-alcoholic steatohepatitis (NASH) are diseases of major importance with a high unmet medical need. Efficacy studies on novel compounds to treat NAFLD/NASH using disease models a...

Humans Animals Severity of Illness Index Deep Learning Biopsy Feasibility Studies Non-alcoholic Fatty Liver Disease Microscopy Datasets as Topic Image Processing, Computer-Assisted Mice Rats Disease Models, Animal Liver

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Data-driven analyses of motor impairments in animal models of neurological disorders.

PLoS biology Nov 21, 2019

Behavior provides important insights into neuronal processes. For example, analysis of reaching movements can give a reliable indication of the degree of impairment in neurological disorders such as stroke, Parkinson disease, or Huntington disease. T...

Forelimb Nervous System Diseases Motor Skills Movement Motor Activity Motor Disorders Neural Networks, Computer Male Animals Image Processing, Computer-Assisted Rats Disease Models, Animal Stroke

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Multi-resolution convolutional neural networks for fully automated segmentation of acutely injured lungs in multiple species.

Medical image analysis Nov 7, 2019

Segmentation of lungs with acute respiratory distress syndrome (ARDS) is a challenging task due to diffuse opacification in dependent regions which results in little to no contrast at the lung boundary. For segmentation of severely injured lungs, loc...

Datasets as Topic Pattern Recognition, Automated Sheep, Domestic Swine Humans Neural Networks, Computer Deep Learning Tomography, X-Ray Computed Disease Models, Animal Animals Respiratory Distress Syndrome Dogs

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Deep learning of spontaneous arousal fluctuations detects early cholinergic defects across neurodevelopmental mouse models and patients.

Proceedings of the National Academy of Sciences of the United States of America Jul 22, 2019

Neurodevelopmental spectrum disorders like autism (ASD) are diagnosed, on average, beyond age 4 y, after multiple critical periods of brain development close and behavioral intervention becomes less effective. This raises the urgent need for quantita...

Humans Female Animals Male Deep Learning Autistic Disorder Pupil Arousal Methyl-CpG-Binding Protein 2 Rett Syndrome Cohort Studies Mice Disease Models, Animal Protein Serine-Threonine Kinases Acetylcholine

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Modelling disease risk for amyloid A (AA) amyloidosis in non-human primates using machine learning.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis Jun 18, 2019

Amyloid A (AA) amyloidosis is found in humans and non-human primates, but quantifying disease risk prior to clinical symptoms is challenging. We applied machine learning to identify the best predictors of amyloidosis in rhesus macaques from availabl...

Wounds and Injuries Macaca mulatta Colitis Serum Amyloid A Protein Adenocarcinoma Disease Models, Animal Models, Statistical Cholesterol, LDL Gastrointestinal Neoplasms Endometriosis Cholesterol, HDL Amyloidosis Triglycerides Arthritis Risk Factors Animals Male Humans Case-Control Studies Diarrhea Machine Learning Biomarkers Retrospective Studies Female

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Real-time analysis of the behaviour of groups of mice via a depth-sensing camera and machine learning.

Nature biomedical engineering May 20, 2019

Preclinical studies of psychiatric disorders use animal models to investigate the impact of environmental factors or genetic mutations on complex traits such as decision-making and social interactions. Here, we introduce a method for the real-time an...

Nerve Tissue Proteins Mice, Knockout Mutation Female Video Recording Machine Learning Behavior, Animal Animals Autistic Disorder Behavioral Research Phenotype Male Social Behavior Mice Microfilament Proteins Disease Models, Animal

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Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition.

ALTEX Apr 18, 2019

Ideally, humane endpoints allow for early termination of experiments by minimizing an animal's discomfort, distress and pain, while ensuring that scientific objectives are reached. Yet, lack of commonly agreed methodology and heterogeneity of cut-off...

Mice, Knockout Systematic Reviews as Topic Stroke Body Weight Supervised Machine Learning Animal Welfare Random Allocation Body Temperature Ethical Review Sepsis Time Factors Mice Disease Models, Animal Mice, Inbred C57BL Female Animals Male Severity of Illness Index

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Exon level machine learning analyses elucidate novel candidate miRNA targets in an avian model of fetal alcohol spectrum disorder.

PLoS computational biology Apr 11, 2019

Gestational alcohol exposure causes fetal alcohol spectrum disorder (FASD) and is a prominent cause of neurodevelopmental disability. Whole transcriptome sequencing (RNA-Seq) offer insights into mechanisms underlying FASD, but gene-level analysis pro...

Big Data Computational Biology Chick Embryo Ethanol Humans Exons Disease Models, Animal Pregnancy Fetal Alcohol Spectrum Disorders Cluster Analysis Female MicroRNAs Animals Unsupervised Machine Learning Gene Expression Profiling Principal Component Analysis Databases, Nucleic Acid

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Deep convolutional neural networks for segmenting 3D in vivo multiphoton images of vasculature in Alzheimer disease mouse models.

PloS one Mar 13, 2019

The health and function of tissue rely on its vasculature network to provide reliable blood perfusion. Volumetric imaging approaches, such as multiphoton microscopy, are able to generate detailed 3D images of blood vessels that could contribute to ou...

Disease Models, Animal Alzheimer Disease Cerebral Cortex Mice, Transgenic Cerebral Angiography Neural Networks, Computer Animals Imaging, Three-Dimensional Mice Humans Microscopy, Fluorescence, Multiphoton

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Enabling single-site laparoscopy: the SPORT platform.

Surgical endoscopy Jan 8, 2019

BACKGROUND: The Single Port Orifice Robotic Technology (SPORT) Surgical System by Titan Medical Inc. is designed to overcome the inherent challenges of minimally invasive single-access procedures. The aim of this preclinical study was to evaluate the...

Cadaver Swine Humans Ergonomics Disease Models, Animal Cholecystectomy Animals Robotics Fundoplication Male Laparoscopy Equipment Design Surgeons

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Explore the latest research on artificial intelligence and machine learning in medicine.

Deep learning enables pathologist-like scoring of NASH models.

Data-driven analyses of motor impairments in animal models of neurological disorders.

Multi-resolution convolutional neural networks for fully automated segmentation of acutely injured lungs in multiple species.

Deep learning of spontaneous arousal fluctuations detects early cholinergic defects across neurodevelopmental mouse models and patients.

Modelling disease risk for amyloid A (AA) amyloidosis in non-human primates using machine learning.

Real-time analysis of the behaviour of groups of mice via a depth-sensing camera and machine learning.

Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition.

Exon level machine learning analyses elucidate novel candidate miRNA targets in an avian model of fetal alcohol spectrum disorder.

Deep convolutional neural networks for segmenting 3D in vivo multiphoton images of vasculature in Alzheimer disease mouse models.

Enabling single-site laparoscopy: the SPORT platform.

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