AIMC Topic: Disease Progression

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Deep learning approach to predict pain progression in knee osteoarthritis.

Skeletal radiology
OBJECTIVE: To develop and evaluate deep learning (DL) risk assessment models for predicting pain progression in subjects with or at risk of knee osteoarthritis (OA).

Identifying multiple sclerosis subtypes using unsupervised machine learning and MRI data.

Nature communications
Multiple sclerosis (MS) can be divided into four phenotypes based on clinical evolution. The pathophysiological boundaries of these phenotypes are unclear, limiting treatment stratification. Machine learning can identify groups with similar features ...

Early Coaching to Increase Water Intake in CKD.

Annals of nutrition & metabolism
INTRODUCTION: In observational studies, increased water intake improves kidney function but not in adults with CKD stage 3 and more. CKD WIT trial has shown a nonsignificant gradual decline in kidney function after 1 year of coaching to increase wate...

Predicting Parkinson's disease trajectory using clinical and neuroimaging baseline measures.

Parkinsonism & related disorders
INTRODUCTION: Predictive biomarkers of Parkinson's Disease progression are needed to expedite neuroprotective treatment development and facilitate prognoses for patients. This work uses measures derived from resting-state functional magnetic resonanc...

Investigating the relationship between the SNCA gene and cognitive abilities in idiopathic Parkinson's disease using machine learning.

Scientific reports
Cognitive impairments are prevalent in Parkinson's disease (PD), but the underlying mechanisms of their development are unknown. In this study, we aimed to predict global cognition (GC) in PD with machine learning (ML) using structural neuroimaging, ...

Leveraging electronic health records data to predict multiple sclerosis disease activity.

Annals of clinical and translational neurology
OBJECTIVE: No relapse risk prediction tool is currently available to guide treatment selection for multiple sclerosis (MS). Leveraging electronic health record (EHR) data readily available at the point of care, we developed a clinical tool for predic...

Early risk assessment for COVID-19 patients from emergency department data using machine learning.

Scientific reports
Since its emergence in late 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic with more than 55 million reported cases and 1.3 million estimated deaths worldwide. While epidemiological and clinical character...

Predicting COVID-19 disease progression and patient outcomes based on temporal deep learning.

BMC medical informatics and decision making
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has caused health concerns worldwide since December 2019. From the beginning of infection, patients will progress through different symptom stages, such as fever, dyspnea or even death. Ide...