AIMC Topic: Dose-Response Relationship, Drug
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Anticancer and anti-inflammatory activities of girinimbine isolated from .
Drug design, development and therapy
Dec 28, 2016
Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a...
Tumor Cells, Cultured
Murraya
Anti-Inflammatory Agents, Non-Steroidal
Zebrafish
Alkaloids
HT29 Cells
Mice
Nitric Oxide
Cell Proliferation
Apoptosis
Lipopolysaccharides
Dose-Response Relationship, Drug
Cell Survival
Antineoplastic Agents, Phytogenic
Drug Screening Assays, Antitumor
Structure-Activity Relationship
Humans
Cytokines
Animals
Simplifying Piperacillin/Tazobactam Dosing: Pharmacodynamics of Utilizing Only 4.5 or 3.375 g Doses for Patients With Normal and Impaired Renal Function.
Journal of pharmacy practice
Dec 21, 2016
OBJECTIVES: To evaluate the pharmacodynamic exposure of piperacillin/tazobactam across the renal function range using 4.5 or 3.375 g dosing regimens.
Adequate tacrolimus concentration for myasthenia gravis treatment.
European journal of neurology
Nov 7, 2016
BACKGROUND AND PURPOSE: A single, oral dose of 3 mg/day tacrolimus, approved for myasthenia gravis (MG) treatment in Japan, was shown to reduce steroid dose and anti-acetylcholine receptor (AChR) antibody titers as well as to improve MG symptoms. How...
Unravelling effects of flavanols and their derivatives on acrylamide formation via support vector machine modelling.
Food chemistry
Oct 13, 2016
This study investigated the effect of flavanols and their derivatives on acrylamide formation under low-moisture conditions via prediction using the support vector regression (SVR) approach. Acrylamide was generated in a potato-based equimolar aspara...
Correlation of compliance to statin therapy with lipid profile and serum HMGCoA reductase levels in dyslipidemic patients.
Indian heart journal
Aug 1, 2016
BACKGROUND: The efficacy of statin therapy may be lost or vary with reduction in compliance and intensity of statin therapy.
Using machine learning to model dose-response relationships.
Journal of evaluation in clinical practice
May 30, 2016
RATIONALE, AIMS AND OBJECTIVES: Establishing the relationship between various doses of an exposure and a response variable is integral to many studies in health care. Linear parametric models, widely used for estimating dose-response relationships, h...
G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.
Journal of vascular research
Apr 12, 2016
Vascular smooth muscle cell (VSMC) migration and proliferation is central to neointima formation in vein graft failure following coronary artery bypass. However, there are currently no pharmacological interventions that prevent vein graft failure thr...
Cell Proliferation
Signal Transduction
Cell Movement
Dose-Response Relationship, Drug
Receptors, G-Protein-Coupled
Humans
Time Factors
Thiourea
HEK293 Cells
Myocytes, Smooth Muscle
Endothelial Cells
Actin Cytoskeleton
rho-Associated Kinases
rhoA GTP-Binding Protein
Muscle, Smooth, Vascular
Thiazolidines
Hydrazones
Aminosalicylic Acids
Naphthols
Purinones
Saphenous Vein
Investigation of the mutagenic and genotoxic activities of LLL-3, a STAT3 inhibitor.
Drug and chemical toxicology
Apr 10, 2016
LLL-3, an anthracene derived compound, has been shown to be a promising therapeutic agent for the treatment of some kinds of cancer such as chronic myeloid leukemia and glioblastoma. However, no data regarding the toxic properties of this compound ha...
Optimized Repopulation of Tendon Hydrogel: Synergistic Effects of Growth Factor Combinations and Adipose-Derived Stem Cells.
Hand (New York, N.Y.)
Mar 15, 2016
Tendon-derived extracellular matrix (ECM) hydrogel has been shown to augment tendon healing in vivo. We hypothesized that reseeding of the gel with adipose-derived stem cells (ASCs) could further assist repopulation of the gel and that combinations ...
A simple and sensitive UHPLC-MS/MS method for quantification of buddlejasaponin IV in rat plasma and its application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis
Dec 29, 2015
Buddlejasaponin IV (BS-IV), a natural triterpene saponin isolated from several herbal plants, has drawn a lot of attention for its anti-inflammatory, antinociceptive, antihyperlipidemia, and antitumor activities. In this study, a simple and sensitive...
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