AIMC Topic: Drug Carriers
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Machine learning-guided fabrication of carbon dot-pepsin nano-conjugates for enhanced bioimaging, synergistic drug delivery, and visible light-induced photosensitization.
Nanoscale
Jun 12, 2025
Carbon dots (CDs) are emerging as next-generation bioimaging agents due to their strong fluorescence, photobleaching resistance, and biocompatibility. However, their small size often limits efficient cell internalization, leading to unspecified cellu...
Supervised machine learning for predicting drug release from acetalated dextran nanofibers.
Biomaterials science
May 13, 2025
Electrospun drug-loaded polymeric nanofibers can improve the efficacy of therapeutics for a variety of implications. By design, these biomaterial platforms can enhance drug bioavailability and site-specific delivery while reducing off-target toxiciti...
Optimizing Neuroprotective Nano-structured Lipid Carriers for Transdermal Delivery through Artificial Neural Network.
Pharmaceutical nanotechnology
Jan 1, 2025
BACKGROUND: Dementia associated with Alzheimer's disease (AD) is a neurological disorder. AD is a progressive neurodegenerative condition that predominantly impacts the elderly population, although it can also manifest in younger people through the i...
Machine learning algorithms to control concentrations of carbon nanocomplexes in a biological medium via optical absorption spectroscopy: how to choose and what to expect?
Applied optics
Sep 20, 2021
A solution of spectroscopic inverse problems, implying determination of target parameters of the research object via analysis of spectra of various origins, is an overly complex task, especially in case of strong variability of the research object. O...
Biohybrid robotics with living cell actuation.
Chemical Society reviews
Jun 22, 2020
As simulators of organisms in Nature, soft robots have been developed over the past few decades. In particular, biohybrid robots constructed by integrating living cells with soft materials demonstrate the unique advantage of simulating the constructi...
A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Barrier and Selectively Delivering siRNA to Neurons for Alzheimer's Disease Treatment.
Current pharmaceutical biotechnology
Jan 1, 2017
BACKGROUND: Alzheimer's disease (AD) is one of most serious threats to human beings, however, the treatment is hindered by blood-brain barrier and poor intra-brain cell selectivity.
Redox-Responsive Amphipathic Dextran Nanomicelles for Solid Tumor Therapy.
Journal of biomedical nanotechnology
Dec 1, 2016
A disulfide bond containing deoxycholic acid-grafted dextran (Dex-SSDCA) was successfully prepared for drug delivery. The Dex-SSDCA polymers can self-assemble into nanomicelles at concentrations below 56 g/mL and encapsulate doxorubicin (DOX) effecti...
Computer-Aided Virtual Screening and Designing of Cell-Penetrating Peptides.
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2015
Cell-penetrating peptides (CPPs) have proven their potential as versatile drug delivery vehicles. Last decade has witnessed an unprecedented growth in CPP-based research, demonstrating the potential of CPPs as therapeutic candidates. In the past, man...
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