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Drug Therapy, Combination

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Adequate tacrolimus concentration for myasthenia gravis treatment.

European journal of neurology
BACKGROUND AND PURPOSE: A single, oral dose of 3 mg/day tacrolimus, approved for myasthenia gravis (MG) treatment in Japan, was shown to reduce steroid dose and anti-acetylcholine receptor (AChR) antibody titers as well as to improve MG symptoms. How...

Impact of renal impairment on platelet reactivity and clinical outcomes during chronic dual antiplatelet therapy following coronary stenting.

European heart journal. Cardiovascular pharmacotherapy
AIMS: Clinical utilization of dual antiplatelet therapy (DAPT) in patients with renal impairment (RI) following percutaneous coronary interventions (PCI) represents an urgent, unmet need choosing optimal agents, duration of treatment, and potential d...

Comparative risk of failure of ABC/3TC or TDF/FTC based first-line regimens in patients with a high viral load.

HIV medicine
OBJECTIVES: To compare the efficacy, in current clinical practice, of first regimens containing abacavir with lamivudine (ABC/3TC) or tenofovir with emtricitabine (TDF/FTC) in patients with baseline viral load ≥100,000 HIV-1 RNA copies/mL.

[Maintenance therapy for chronic hepatitis C].

Gastroenterologie clinique et biologique
Therapy of chronic hepatitis C presently achieves 60% of sustained virological response, with clear on improvement of liver histology. Failure to eradicate HCV infection does not mean that the patient is non-responsive to therapy and indeed most pati...

[Retreatment strategies for the patients with HCV infection].

Przeglad epidemiologiczny
Despite recent advances in the treatment of chronic hepatitis C, especially introduction of combined therapy with pegylated interferons with ribavirin, significant number of patients fails to achieve sustained virologic response. Such patients may be...

Towards an expert system for accurate diagnosis and progress monitoring of Parkinson's disease.

Advances in experimental medicine and biology
While Parkinson's disease is a chronic and progressive movement disorder, no one can predict which symptoms will affect an individual patient. At the present time there is no cure for Parkinson's disease but instead a variety of alternative treatment...