AIMC Topic: Drug Therapy, Combination

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Antimicrobial and synergistic activity of thiazoline derivatives in combination with conventional antibiotics against multidrug resistant Staphylococcus aureus isolated from abscess drainage samples.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
Emergence and spread of multidrug resistant (MDR) Staphylococcus aureus strains is becoming major challenge in treatment of soft tissue infections. This study aimed to explore antimicrobial and synergistic antimicrobial potential of three commerciall...
Ribotyping Staphylococcal Infections Thiazoles Humans Thiazolidines Drug Synergism Anti-Bacterial Agents Abscess Drug Resistance, Multiple, Bacterial Disk Diffusion Antimicrobial Tests Staphylococcus aureus Drug Therapy, Combination Drainage
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Artificial intelligence in drug combination therapy.

Briefings in bioinformatics Jul 19, 2019
Currently, the development of medicines for complex diseases requires the development of combination drug therapies. It is necessary because in many cases, one drug cannot target all necessary points of intervention. For example, in cancer therapy, a...
Neural Networks, Computer Artificial Intelligence Machine Learning Neoplasms Deep Learning Humans Least-Squares Analysis Drug Therapy, Combination Computational Biology Drug Interactions Drug Resistance Logistic Models Expert Systems Stochastic Processes Gene Expression Regulation, Neoplastic Support Vector Machine Bayes Theorem
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[A real-world study of paritaprevir/ritonavir-ombitasvir combined with dasabuvir in the treatment of genotype 1b chronic hepatitis C].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Dec 20, 2018
To recognize the efficacy and safety of paritaprevir/ritonavir-ombitasvir combined with dasabuvir (OBV/PTV/RTV+DSV) in the treatment of genotype 1b chronic hepatitis C. Patients with genotype 1b chronic hepatitis C who were admitted to the People's...
Cyclopropanes Sulfonamides Hepacivirus Proline Ritonavir Drug Therapy, Combination Hepatitis C, Chronic Valine Anilides Carbamates Middle Aged China Antiviral Agents Genotype Treatment Outcome Humans Male Lactams, Macrocyclic Macrocyclic Compounds Ribavirin 2-Naphthylamine Uracil
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Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate.

Pharmaceutical biology Dec 1, 2018
CONTEXT: Garcinia mangostana Linn. (Guttiferae) pericarp is used as a traditional medicine in South Asia to treat inflammatory diseases.
Garcinia mangostana Drug Synergism Drug Therapy, Combination Collagen Arthritis, Experimental Animals Rats Male Ethanol Rats, Sprague-Dawley Drugs, Chinese Herbal Methotrexate
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Levofloxacin Pharmacokinetics/Pharmacodynamics, Dosing, Susceptibility Breakpoints, and Artificial Intelligence in the Treatment of Multidrug-resistant Tuberculosis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Nov 28, 2018
BACKGROUND: Levofloxacin is used for the treatment of multidrug-resistant tuberculosis; however the optimal dose is unknown.
Mycobacterium tuberculosis Drug Therapy, Combination Monte Carlo Method Levofloxacin Humans Artificial Intelligence Algorithms Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Sputum Antitubercular Agents Tuberculosis, Multidrug-Resistant Tuberculosis, Pulmonary
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Proton pump inhibitors receiving and prognosis of patients after scheduled percutaneous coronary interventions.

Terapevticheskii arkhiv Sep 20, 2018
AIM: The urgency of the study is determined by the lack of data necessary in order to assess the safety of prolonged use of proton pump inhibitors (PPI) in patients with IHD combined with anti-aggregant therapy. The aim of the study was to study the ...
Platelet Aggregation Inhibitors Humans Proton Pump Inhibitors Prospective Studies Risk Adjustment Prognosis Female Aged Acute Coronary Syndrome Drug Therapy, Combination Gastrointestinal Hemorrhage Russia Long Term Adverse Effects Male Myocardial Ischemia Middle Aged Registries Percutaneous Coronary Intervention Coronary Restenosis
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[Young women with HIV infection acquired by vertical transmission: Expectations of having uninfected children].

Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia Dec 1, 2016
INTRODUCTION: Pediatric antiretroviral therapy (ART), changed the prognosis of the disease, allowing young women infected by vertical transmission (TV) to be pregnant without risk for their fetus of acquiring this infection.
Follow-Up Studies CD4 Lymphocyte Count Drug Therapy, Combination Infectious Disease Transmission, Vertical Pregnancy Complications, Infectious HIV Infections Viral Load Anti-HIV Agents Humans Genotype Pregnancy Outcome Pregnancy Female Infant, Newborn Young Adult Adolescent
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A Randomized Controlled Trial Study on the Effect of Adding Dexmedetomidine to Bupivacaine in Supraclavicular Block Using Ultrasound Guidance.

Ethiopian journal of health sciences Nov 1, 2016
BACKGROUND: The benefits of regional anesthetic techniques are well established. Use of additives to local anesthetics can prolong these benefits. The aim of this study was to find out the effect of adding dexmedetomidine to bupivacaine for supraclav...
Hemodynamics Humans Time Factors Anesthetics, Local Female Double-Blind Method Adult Analgesia Dexmedetomidine Male Analgesics, Non-Narcotic Middle Aged Bupivacaine Drug Therapy, Combination Brachial Plexus Block
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The effect of tramadol and tramadol + gabapentin combination in patients with lumbar disc herniation after epidural steroid injection.

Turkish journal of medical sciences Jan 1, 2015
BACKGROUND/AIM: To compare the effects of tramadol-only treatment and tramadol + gabapentin treatment in patients who had received an epidural steroid injection.
Bupivacaine Lumbar Vertebrae Analgesics Administration, Oral Injections, Epidural Middle Aged Glucocorticoids Anesthetics, Local Disability Evaluation Single-Blind Method Amines Cyclohexanecarboxylic Acids Gabapentin Triamcinolone Acetonide Visual Analog Scale Drug Therapy, Combination Intervertebral Disc Displacement Low Back Pain Tramadol gamma-Aminobutyric Acid Humans Prospective Studies Female Adult Male
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Towards an expert system for accurate diagnosis and progress monitoring of Parkinson's disease.

Advances in experimental medicine and biology Jan 1, 2015
While Parkinson's disease is a chronic and progressive movement disorder, no one can predict which symptoms will affect an individual patient. At the present time there is no cure for Parkinson's disease but instead a variety of alternative treatment...
Humans Carbidopa Deep Brain Stimulation Algorithms Expert Systems Biomarkers Drug Therapy, Combination Sensitivity and Specificity Antiparkinson Agents Disease Progression Levodopa Parkinson Disease
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