AIMC Topic: Escherichia coli

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Inhibiting heme piracy by pathogenic Escherichia coli using de novo-designed proteins.

Nature communications
Iron is an essential nutrient for most bacteria and is often growth-limiting during infection, due to the host sequestering free iron as part of the innate immune response. To obtain the iron required for growth, many bacterial pathogens encode trans...

Application of MALDI-TOF MS-based peptidome profiling for the identification of Bacillus cereus, Staphylococcus aureus, and Escherichia coli in single and mixed inoculum.

Food chemistry
The detection of mixed-species bacterial samples plays a vital role in ensuring food safety, yet research in this area remains notably limited. This study investigates the integration of MALDI-TOF MS-derived peptidome profiles with artificial intelli...

Quantifying complexity in DNA structures with high resolution Atomic Force Microscopy.

Nature communications
DNA topology is essential for regulating cellular processes and maintaining genome stability, yet it is challenging to quantify due to the size and complexity of topologically constrained DNA molecules. By combining high-resolution Atomic Force Micro...

Data-driven protease engineering by DNA-recording and epistasis-aware machine learning.

Nature communications
Protein engineering has recently seen tremendous transformation due to machine learning (ML) tools that predict structure from sequence at unprecedented precision. Predicting catalytic activity, however, remains challenging, restricting our capabilit...

Experimentally profiling dielectric properties of Escherichia coli and Staphylococcus aureus by movement velocity and force.

Scientific reports
The gradual research in integrating artificial intelligence in the Dielectrophoresis system is rapid since the evolution of AI in every aspect of technology since the early 2020s. The benefits of AI integration into DEP systems include improving posi...

Modeling host-pathway dynamics at the genome scale with machine learning.

Metabolic engineering
Pathway engineering offers a promising avenue for sustainable chemical production. The design of efficient production systems requires understanding complex host-pathway interactions that shape the metabolic phenotype. While genome-scale metabolic mo...

Microbial vitamin biosynthesis links gut microbiota dynamics to chemotherapy toxicity.

mBio
Dose-limiting toxicities pose a major barrier to cancer treatment. While preclinical studies show that the gut microbiota influences and is influenced by anticancer drugs, data from patients paired with careful side effect monitoring remains limited....

Comparative study on antibacterial activities and removal of iron ions from water using novel modified sand with silver through the hydrothermal technique.

Scientific reports
The hydrothermal-calcination technique was used to modify raw sand with silver (Ag) at different weight percentages: 2%, 5%, and 10% using silver nitrate. The raw and sand-coated Ag nanoparticle samples were analyzed using various techniques, includi...

Engineered Bacteria Convert a 3-Bit Binary Code to a 3-Bit Gray Code by Multicellular Artificial-Neural-Network-Type Architecture.

ACS synthetic biology
The neuromorphic computing with genetically engineered cells is still in its infancy and shows great promise to solve various complex computational problems. The success of such computing is dependent on the expansion of its capability to build new a...