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Development and evaluation of a machine learning-based point-of-care screening tool for genetic syndromes in children: a multinational retrospective study.

The Lancet. Digital health
BACKGROUND: Delays in the diagnosis of genetic syndromes are common, particularly in low and middle-income countries with limited access to genetic screening services. We, therefore, aimed to develop and evaluate a machine learning-based screening te...

Visual Analytics for Hypothesis-Driven Exploration in Computational Pathology.

IEEE transactions on visualization and computer graphics
Recent advances in computational and algorithmic power are evolving the field of medical imaging rapidly. In cancer research, many new directions are sought to characterize patients with additional imaging features derived from radiology and patholog...

Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome.

Scientific reports
Delivery mode and perinatal antibiotics influence gut microbiome composition in children. Most microbiome studies have used the sequencing of the bacterial 16S marker gene but have not reported the metabolic function of the gut microbiome, which may ...

Quantitative analysis of metastatic breast cancer in mice using deep learning on cryo-image data.

Scientific reports
Cryo-imaging sections and images a whole mouse and provides ~ 120-GBytes of microscopic 3D color anatomy and fluorescence images, making fully manual analysis of metastases an onerous task. A convolutional neural network (CNN)-based metastases segmen...

Efficacy of a comprehensive binary classification model using a deep convolutional neural network for wireless capsule endoscopy.

Scientific reports
The manual reading of capsule endoscopy (CE) videos in small bowel disease diagnosis is time-intensive. Algorithms introduced to automate this process are premature for real clinical applications, and multi-diagnosis using these methods has not been ...

Use of artificial intelligence for image analysis in breast cancer screening programmes: systematic review of test accuracy.

BMJ (Clinical research ed.)
OBJECTIVE: To examine the accuracy of artificial intelligence (AI) for the detection of breast cancer in mammography screening practice.

HOX cluster and their cofactors showed an altered expression pattern in eutopic and ectopic endometriosis tissues.

Reproductive biology and endocrinology : RB&E
Endometriosis is major gynecological disease that affects over 10% of women worldwide and 30%-50% of these women have pelvic pain, abnormal uterine bleeding and infertility. The cause of endometriosis is unknown and there is no definite cure mainly b...

Acceptability of Socially Assistive Robots Among Cognitively Intact Older Adults: An Integrative Review.

Journal of gerontological nursing
An aging population and technology are two rapidly evolving phenomena occurring simultaneously worldwide. To examine the literature on the acceptability of socially assistive robots (SAR) among cognitively intact older adults, an integrative review o...

Automatic segmentation of gadolinium-enhancing lesions in multiple sclerosis using deep learning from clinical MRI.

PloS one
Gadolinium-enhancing lesions reflect active disease and are critical for in-patient monitoring in multiple sclerosis (MS). In this work, we have developed the first fully automated method to segment and count the gadolinium-enhancing lesions from rou...

A machine-learning-based method to predict adverse events in patients with dilated cardiomyopathy and severely reduced ejection fractions.

The British journal of radiology
OBJECTIVE: Patients with dilated cardiomyopathy (DCM) and severely reduced left ventricular ejection fractions (LVEFs) are at very high risks of experiencing adverse cardiac events. A machine learning (ML) method could enable more effective risk stra...