AIMC Topic: Female

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Breast cancer classification based on the integration of diagnostic algorithms for calcifications and masses using a mixture of experts.

PloS one
PURPOSE: To investigate the effectiveness of an integrated deep-learning (DL) algorithm, the Mixture of Radiological Findings Specific Experts (MoRFSE), in breast cancer classification by imitating the diagnostic decision-making process of radiologis...

3,6'-Disinapoyl sucrose modulates GALE-mediated metabolic reprogramming to alleviate asthmatic airway inflammation.

International immunopharmacology
BACKGROUND: Asthma is a heterogeneous disease characterized by chronic airway inflammation and metabolic dysregulation. Recent studies highlight the role of glycolysis and oxidative phosphorylation (OXPHOS) imbalance in asthma pathogenesis, yet the u...

KPNA2 expression as a biomarker for immunosuppressive microenvironment predicting response to TKI and immunotherapy in metastatic renal cell carcinoma.

European journal of pharmacology
BACKGROUND: Immunotherapy (IO) combined with tyrosine kinase inhibitors (TKI) are now first-line therapy for advanced renal cell carcinoma (RCC), though reliable predictive biomarkers remain elusive. Recent evidence demonstrates that karyopherin α2 s...

Cognitive prediction using regional connectivities and network biomarkers in Alzheimer's disease.

Neuroscience
Achieving a deep understanding of brain mechanisms requires multi-scale perspectives to capture the architecture of complex networks. In this study, we focused on patients with cognitive impairment and constructed individual brain networks from neuro...

AlzFormer: Video-based space-time attention model for early diagnosis of Alzheimer's disease.

Neuroscience
Early and accurate Alzheimer's disease (AD) diagnosis is critical for effective intervention, but it is still challenging due to neurodegeneration's slow and complex progression. Recent studies in brain imaging analysis have highlighted the crucial r...

Potential of Proteomics in Forensic Phenotyping: A Focus on Biological Sex Estimation.

Journal of proteome research
Forensic DNA analysis is well established for phenotyping, providing valuable investigative leads. Proteomics, the large-scale study of proteins, is emerging as a complementary tool to DNA analysis, particularly for enhancing the evidential value of ...

Machine learning prediction of clinical pregnancy in endometriosis patients following fresh IVF/ICSI-ET.

European journal of medical research
BACKGROUND: Fresh embryo transfer reduces waiting time and minimizes embryo cryodamage for endometriosis (EM) patients. The current prediction models for fresh embryo transfer outcomes in EM primarily rely on logistic regression, with limited applica...

Comparing supervised machine learning algorithms for the prediction of partial arterial pressure of oxygen during craniotomy.

BMC medical informatics and decision making
BACKGROUND AND OBJECTIVES: Brain tissue oxygenation is usually inferred from arterial partial pressure of oxygen (paO), which is in turn often inferred from pulse oximetry measurements or other non-invasive proxies. Our aim was to evaluate the feasib...

Detecting suicide risk in bipolar disorder patients from lymphoblastoid cell lines genetic signatures.

Translational psychiatry
This research aimed to develop a machine learning algorithm to predict suicide risk in bipolar disorder (BD) patients using RNA sequencing analysis of lymphoblastoid cell lines (LCLs). By identifying differentially expressed genes (DEGs) between high...

Artificial intelligence approach to optimise safety for hospitalised patients with dementia.

BMJ open quality
BACKGROUND: The aim of the study is to develop a machine learning (ML) model to identify contributing factors to dementia-related safety events using patient safety event report data.