AIMC Topic: Gene Expression
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D-Aspartate amends reproductive performance of aged roosters by changing gene expression and testicular histology.
Reproduction, fertility, and development
Jun 1, 2018
Male broiler breeders (n=32) of 55 weeks of age were administered four different doses of capsulated d-aspartate (DA; 0, 100, 200 or 300mgkg-1day-1, p.o. (DA0, DA100, DA200 and DA300 respectively)) for 12 successive weeks to assess reproductive perfo...
Graph-based semi-supervised learning with genomic data integration using condition-responsive genes applied to phenotype classification.
Journal of the American Medical Informatics Association : JAMIA
Jan 1, 2018
OBJECTIVE: Data integration methods that combine data from different molecular levels such as genome, epigenome, transcriptome, etc., have received a great deal of interest in the past few years. It has been demonstrated that the synergistic effects ...
Usual Interstitial Pneumonia Can Be Detected in Transbronchial Biopsies Using Machine Learning.
Annals of the American Thoracic Society
Nov 1, 2017
RATIONALE: Usual interstitial pneumonia (UIP) is the histopathologic hallmark of idiopathic pulmonary fibrosis. Although UIP can be detected by high-resolution computed tomography of the chest, the results are frequently inconclusive, and pathology f...
Gene Expression
Biopsy
Logistic Models
Sequence Analysis, RNA
Idiopathic Pulmonary Fibrosis
Diagnosis, Differential
Adult
Female
Sensitivity and Specificity
Aged
Lung
Humans
Male
Aged, 80 and over
Adolescent
Machine Learning
Middle Aged
Young Adult
Cohort Studies
Tomography, X-Ray Computed
ROC Curve
Identification of human flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening.
Molecular bioSystems
Jul 25, 2017
Human Flap endonuclease1 (FEN1) is an enzyme that is indispensable for DNA replication and repair processes and inhibition of its Flap cleavage activity results in increased cellular sensitivity to DNA damaging agents (cisplatin, temozolomide, MMS, e...
[Effect of porcine small intestinal submucosa extracellular matrix in promoting vitality and functional gene expression of hepatocyte].
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
May 15, 2017
OBJECTIVE: To investigate the effect of porcine small intestinal submucosa extracellular matrix (PSISM) on the vitality and gene regulation of hepatocyte so as to lay the experimental foundation for the application of PSISM in liver tissue engineerin...
TSSPlant: a new tool for prediction of plant Pol II promoters.
Nucleic acids research
May 5, 2017
Our current knowledge of eukaryotic promoters indicates their complex architecture that is often composed of numerous functional motifs. Most of known promoters include multiple and in some cases mutually exclusive transcription start sites (TSSs). M...
The Effect of Artemisia fragrans Willd: Essential Oil on Inducible Nitric Oxide Synthase Gene Expression and Nitric Oxide Production in Lipopolysaccharide-stimulated Murine Macrophage Cell Line.
Iranian journal of allergy, asthma, and immunology
Dec 1, 2016
The genus Artemisia is estimated to comprise over 800 species with anti-cancer, anti-fungal, anti-oxidant and anti-inflammatory properties. Artemisia fragrans (A. fragrans), a species that belongs to genus Artemisia, is rich in monoterpenes and sesqu...
[Gene optimization and efficient expression of Trichoderma reesei Cel5A in Pichia pastoris].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Oct 25, 2016
Deficient activity of endo-1,4-beta-glucanase II (Cel5A) secreted by Trichoderma reesei is one of the challenges involved in effective cellulase saccharification of cellulosic substrates. Therefore, we expressed Cel5A in Pichia pastoris by constructi...
Higher order methylation features for clustering and prediction in epigenomic studies.
Bioinformatics (Oxford, England)
Sep 1, 2016
MOTIVATION: DNA methylation is an intensely studied epigenetic mark, yet its functional role is incompletely understood. Attempts to quantitatively associate average DNA methylation to gene expression yield poor correlations outside of the well-under...
[Study of FN1 and ZNF438 gene expression negatively regulated by androgen receptor in androgen-independent LNCaP cells].
Zhonghua yi xue za zhi
Dec 19, 2015
OBJECTIVE: To verify whether FN1 and ZNF438 are the androgen receptor(AR) target genes in LNCaP-AI cells and investigate the effects of AR exerts on FN1 and ZNF438 gene expression.
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