Microorganisms remain a prolific source of bioactive compounds, yet discovery efforts are often hindered by traditional methods and the repeated isolation of known molecules. In the post-genomics era, advances in genome mining and multi-omics technol...
Drug resistance remains one of the primary challenges in effective cancer therapy. In this study, we employed a deep neural network (DNN)-based transfer learning (TL) approach to predict drug response and uncover drug resistance mechanisms. We integr...
BACKGROUND: Breast cancer prognosis remains challenging due to tumor heterogeneity and the limited predictive power of conventional clinical models. Integrating imaging features with molecular data may improve individualized risk stratification and c...
Precision oncology enables molecularly guided cancer therapy through multi-omics profiling, AI-driven classification, and biomarker-targeted interventions. Disulfidptosis has emerged as a promising therapeutic target, yet no ovarian cancer classifica...
Homologous recombination deficiency (HRD) is a critical biomarker for guiding targeted therapies, yet the full range of somatic alterations driving HRD across cancers remains incompletely characterized. Here, we present a tumor-agnostic machine learn...
BACKGROUND: Accurate multicancer classification constitutes a cornerstone of modern oncology, offering critical insights into diagnosis, therapeutic decision-making, and prognostication. Numerous existing approaches, however, remain restricted to lim...
BACKGROUND: Chrysophrys auratus (family: Sparidae), commonly known as Australasian snapper, is a warm-water species being developed as a candidate for aquaculture in New Zealand. Genomic selection of elite snapper offers significant potential to acce...
Modeling long-range DNA dependencies is crucial for understanding genome structure and function across diverse biological contexts. However, effectively capturing these dependencies, which may span millions of base pairs in tasks such as three-dimens...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.