AIMC Topic: Humans

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Identification of the core genes KLRB1 and RETN as potential shared diagnostic markers for major depressive disorder and systemic lupus erythematosus through bioinformatics and machine learning methodologies.

Journal of neuroimmunology
This study investigates the shared molecular mechanisms between major depressive disorder (MDD) and systemic lupus erythematosus (SLE) through integrated bioinformatics analysis. Analysis of multiple GEO datasets identified 23 common differentially e...

Construction of a Minimal Sensor Array Using Fingerprint Protein Corona on Nanostars for Detecting Protein Isoforms and Disease States.

ACS nano
Signature-based protein detection coupled with machine learning algorithms has revolutionized traditional sensing methods, providing rapid, inexpensive, and selectivity-driven detection without the use of specialized equipment. This strategy leverage...

The role of IRF-1 in mediating T-cell immune imbalance in systemic lupus erythematosus and the construction of a diagnostic model.

Autoimmunity
Systemic lupus erythematosus (SLE), characterized by immune dysregulation, urgently requires improved diagnostic tools and mechanistic insights. The role of interferon regulatory factor-1 (IRF-1) remains unclear. We integrated single-cell transcripto...

Reducing Artifact Preprocessing in Heart Rate Variability-Based Personalized Psychosis Prediction Using Adaptive Long Short-Term Memory Models.

International journal of neural systems
This research looks at the use of long-short-term memory (LSTM) networks to predict psychosis, in patients within the schizophrenia spectrum, based on Heart Rate Variability (HRV) data acquired from wearable devices. Our primary objective is to test ...

Magnetically Controlled Pollen Microrobots for Underwater Bubble Manipulation-Adhesion, Transport, and Photocontrolled Release.

ACS applied materials & interfaces
The traditional approach has significant limitations in designing and manufacturing high-performance micro-nanorobots with complex three-dimensional structures and response characteristics at the micro-nanoscale, making it difficult to meet practical...

Ultrasensitive Nucleic Acid Testing: From Foundational Research to Clinical Translation.

ACS nano
The ability to detect nucleic acids at ever-lower detection limits is crucial in molecular science, enabling disease management to shift from reactive response to proactive prediction and personalized medicine. This review synthesizes the technologic...

Systematic review and comparison of machine learning and conventional statistical models for predicting cardiovascular events in dialysis patients.

Renal failure
This systematic review aimed to evaluate the performance of machine learning (ML) models and conventional statistical models (CSMs) for predicting cardiovascular events in dialysis patients. Following PRISMA guidelines, eligible studies were searched...

AI-driven discovery of dual antiaging and anti-AD therapeutics via PROTAC target deconvolution of a super-enhancer-regulated axis.

Science advances
The lack of safe, durable therapeutics that act against both biological aging and Alzheimer's disease is an unmet clinical need. To bridge this gap, we devised an artificial intelligence (AI)-enabled approach that pairs rapid compound triage with mec...

Plasma metabolomics disentangles T2DM- and CAD-specific dysmetabolism and identifies potential biomarkers for CAD risk escalation in diabetic patients.

Cardiovascular diabetology
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major driver of coronary artery disease (CAD). Prior studies often conflate T2DM- and CAD-specific metabolic alterations, limiting insights into CAD pathogenesis in T2DM. This study aimed to distinguis...

The ADVANCE toolkit: Automated descriptive video annotation in naturalistic child environments.

Behavior research methods
Video recordings are commonplace for observing human and animal behaviours, including interindividual interactions. In studies of humans, analyses for clinical applications remain particularly cumbersome, requiring human-based annotation that is time...