AIMC Topic: Humans

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Multi-omics and machine learning identify FN1 and ALDH2 as diagnostic biomarkers and therapeutic targets in early and late diabetic kidney disease.

Renal failure
Diabetic kidney disease (DKD), the leading cause of end-stage kidney disease worldwide, demands deeper molecular characterization to improve clinical management. This study employed an integrated multi-omics approach to identify stage-specific biomar...

Integrative Deep Learning of Genomic and Clinical Data for Predicting Treatment Response in Newly Diagnosed Epilepsy.

Neurology
BACKGROUND AND OBJECTIVES: Epilepsy is a common neurologic disorder. Although antiseizure medications (ASMs) are the first-line treatment, identifying the most effective ASM for each individual remains a trial-and-error process. Genetic variation may...

A Single-step Platinum Nanoparticle-Enhanced Lateral Flow Immunoassay Platform for Rapid Detection of Influenza A Virus.

ACS infectious diseases
Lateral flow immunoassays (LFIAs) are widely used point-of-care (POC) diagnostic tools, but their limited sensitivity can hinder reliable diagnoses. To address this limitation, we developed a novel POC diagnostic platform for the highly sensitive det...

Non-linear association between Life's Essential 8 and diabetic retinopathy: mediating role of depression in US adults with diabetes.

BMC public health
BACKGROUND: Life's Essential 8 (LE8) is a comprehensive cardiovascular health (CVH) metric that is associated with chronic diseases. This study aimed to investigate the association between LE8 and diabetic retinopathy (DR) and the mediating role of d...

Multimodal contrastive learning on rs-fMRI to quantify whole-brain network recovery after hypothalamic hamartoma surgery.

Biomedical engineering online
INTRODUCTION: Epilepsy due to hypothalamic hamartoma (HH) is associated with epileptic encephalopathy and often requires surgical intervention, as medications are ineffective at reducing the seizures. However, the first step of disentangling the impa...

Comparing radiomics, deep learning, and fusion models for predicting occult pleural dissemination in patients with non-small cell lung cancer: a retrospective multicenter study.

BMC cancer
BACKGROUND: Occult pleural dissemination (PD) in non-small cell lung cancer (NSCLC) patients is likely to be missed on computed tomography (CT) scans, associated with poor survival, and generally contraindicated for radical surgery. This study aimed ...

From past to future: a review of methods for assessing physical activity energy expenditure.

Journal of health, population, and nutrition
BACKGROUND: Physical activity energy expenditure (PAEE) assessment is important for helping individuals maintain energy balance. This study adopts a technological evolution perspective to systematically examine the historical evolution and current pr...

The effects of combining anodal transcranial direct current stimulation with robot-assisted gait training on lower limb motor function and the motor cortex regulation of stroke patients.

Journal of neuroengineering and rehabilitation
BACKGROUND: The therapeutic effect and underlying mechanism of combining transcranial direct current stimulation (tDCS) with robot-assisted gait training (RAGT) for stroke patients remain unclear.

Comprehensive analysis of metabolic and molecular alterations in the blood of patients with Sjögren's syndrome based on untargeted metabolomics analysis.

BMC medical genomics
BACKGROUND: Sjögren's syndrome (SS) is a chronic autoimmune disorder marked by lymphocytic infiltration of exocrine glands, leading to xerostomia, keratoconjunctivitis sicca, and systemic involvement including fatigue, arthralgia, and visceral organ ...

New lung ultrasound system for rapid triage of pulmonary disease without a radiologist or sonographer.

BMC pulmonary medicine
BACKGROUND: Most people in the world lack access to medical imaging including for assessment of pulmonary disease. We sought to improve access to pulmonary imaging by developing a rapid automated system for triage of pulmonary disease using lung ultr...